CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1885
Family Name Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide Family
No. of Seeds 3 No. of Other Members 34
Family Centroid CFAMM00253443 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 1A and Peptidyl-prolyl cis-trans isomerase A Binder Superfamily
Class Class 1612

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Histamine H1 receptor Ligand Mepyramine Family 5 65
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 31
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Smoothened homolog Inhibitor LDE225 Family 3 76
AP26113 family 16 90
SB1518 family 7 103
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
E7050 family 2 13
Serine/threonine-protein kinase Chk1 Inhibitor LY2603618 Family 2 1
MK-6096 family 3 69
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Fatty-acid amide hydrolase 1 Inhibitor 1-(oxazolo[4,5-b]pyridi... 19 34
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Hepatocyte growth factor receptor Ligand BMS-777607 Family 10 1
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Mitogen-activated protein kinase 14 Inhibitor Pamapimod Family 15 7
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Transient receptor potential cation channel subfamily V member... 2 12
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Aldo-keto reductase family 1 member B10 and Aldose reductase i... 4 13
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Neuropeptide Y receptor type 5 ligand 8-[[(5-cyclobutyloxypyri... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... 2 0
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
5-hydroxytryptamine receptor 1A ligand 4-chloro-N-[(2S)-2-[4-(... 4 0
Serine/threonine-protein kinase Chk1 inhibitor Chk1_49 family 6 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase Chk1 and Ribosomal protein S6 ... 4 1
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 4 1
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(2,6-di... 14 8
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
Beta-secretase 1 and Beta-secretase 2 inhibitor 7-fluoro-3-(5-... 2 7
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 2
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Serine/threonine-protein kinase Chk1 inhibitor AGN-PC-076BW0 f... 2 0
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0DB8TJ family 2 0
Orexin receptor type 1 and Orexin receptor type 2 ligand (1R,2... 6 1
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Metabotropic glutamate receptor 5 and Cytochrome P450 3A4 liga... 3 7
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Transient receptor potential cation channel subfamily V member... 6 1
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Reverse transcriptase/RNaseH inhibitor 1-(5-chloropyridin-2-yl... 3 0
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 5 13
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 1 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Reverse transcriptase/RNaseH inhibitor PETT deriv. 14 family 1 0
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Tyrosine-protein kinase Lck inhibitor N-(5-tert-butyl-1,2-oxaz... 1 0
Peroxisome proliferator-activated receptor gamma and Cytochrom... 1 1
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
C-C chemokine receptor type 3 ligand SureCN6338683 family 1 2
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-071H3F fa... 3 0
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 1
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-077D0D family 3 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Tyrosine-protein kinase receptor Tie-1 and Receptor-type tyros... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Transient receptor potential cation channel subfamily V member... 1 3
Metabotropic glutamate receptor 5 ligand AGN-PC-09QJ1Q family 1 0
Diacylglycerol O-acyltransferase 1 inhibitor SureCN2789698 family 2 8
Macrophage migration inhibitory factor homologue inhibitor 4-[... 2 1
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 1 1
Transient receptor potential cation channel subfamily V member... 2 3
Glucokinase inhibitor 4-methyl-N-[3-phenylmethoxy-5-(pyridin-2... 1 8
Corticotropin-releasing factor receptor 1 ligand N-[(1R,2S)-2-... 3 0
Coagulation factor X and Cationic trypsin inhibitor SureCN6578... 4 11
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-073... 1 1
TGF-beta receptor type-1 ligand 2wou family 1 0
Huntingtin and Nuclear receptor ROR-gamma ligand CHEMBL1324975... 1 0
Sodium channel protein type 9 subunit alpha and Sodium channel... 2 0
5-(4-methoxyphenyl)-4-oxo-1H-pyrido[2,3-d]pyrimidin-2-olate NP... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00253443 DNC006104 Investigative Drug 3-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide
CFAMM00253433 DNC006105 Investigative Drug 1-(3-benzyloxy-pyridin-2-yl)-3-phenyl-urea
CFAMM00253432 DNC006103 Investigative Drug 4-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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