CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID189
Family Name Integrin alpha-4 Inhibitor BIO-1211 Family
No. of Seeds 16 No. of Other Members 83
Family Centroid CFAMM00183624 Functional Category Investigative Drug with Natural Product
Superfamily Integrin alpha-4 Inhibitor BIO-1211 Superfamily
Class Class 1455

Cousin Family NamesSeedsMembers
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Thymidylate synthase Inhibitor Leucovorin/5-fluorouracil Family 9 83
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Cyclophilin receptor and Cyclosporine receptor Ligand D-43787 ... 2 13
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Integrin beta-3 Inhibitor L-750034 Family 7 38
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Integrin beta-3 Inhibitor Lotrafiban Family 5 1
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Protein kinase C eta type and Protein kinase C delta type Inhi... 9 12
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Leukotriene A-4 hydrolase Inhibitor N5-[4-(n-phenylamino)pheny... 2 3
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Phospholipase D1 Inhibitor Halopemide Family 17 111
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Leukotriene A-4 hydrolase Inhibitor SA-6541 Family 4 32
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 5
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 6 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Angiotensin-converting enzyme inhibitor AGN-PC-074KD3 family 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Angiotensin-converting enzyme inhibitor (2R)-1-[4-carboxy-4-(p... 3 3
Caspase-1 inhibitor (3S)-5-[[(3aS,7aS)-2-oxo-3a,4,5,6,7,7a-hex... 3 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Angiotensin-converting enzyme inhibitor (2S)-1-[(2S)-2-sulfany... 7 23
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 2 0
Pol polyprotein inhibitor Lysine Sulfonamide 11o family 2 6
Mitogen-activated protein kinase 1 and M17 leucyl aminopeptida... 1 21
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Dipeptidyl peptidase 4 inhibitor SureCN1499864 family 4 7
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[1-[2-[4-[(2... 2 8
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Furin inhibitor N-[(2S)-1-[[(2S)-1-[[(2S)-1-(4-carbamimidoylan... 3 16
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-... 3 3
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Angiotensin-converting enzyme inhibitor (2S)-2-[[(3R)-5-(carbo... 6 4
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
Angiotensin-converting enzyme inhibitor 1-[(2R,4R)-4-carboxy-2... 2 3
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
fMet-Leu-Phe receptor ligand (2S)-2-[[(2S)-2-[[(2S)-2-[(4-chlo... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-037CNR f... 5 8
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Angiotensin-converting enzyme inhibitor 2-(N-[(2S)-6-amino-2-[... 2 1
Atrial natriuretic peptide receptor 1 and Atrial natriuretic p... 3 0
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
Granzyme B and Caspase-3 inhibitor CHEMBL304368 family 2 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3257002 f... 8 4
Tryptase alpha/beta-1 and Tryptase delta inhibitor SureCN33323... 1 3
Caspase-8 and Caspase-3 inhibitor (3S)-3-[[(2S)-4-methyl-2-[[2... 3 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[4-[2-[... 1 0
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 5
Neprilysin and Angiotensin-converting enzyme inhibitor 3-[(3S)... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-[[(2S)... 1 1
Collagenase 3 and Interstitial collagenase inhibitor (2R,3S)-N... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-009EMK... 2 1
Beta-lactamase inhibitor (1R,5S)-4-[(4-carbamoylphenyl)carbamo... 3 2
C-C chemokine receptor type 5 ligand (2R)-2-cyclohexyl-2-[(3S,... 1 3
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4
Gastrin/cholecystokinin type B receptor ligand 3-[3-[[2-[5-cyc... 2 1
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Integrin beta-3 and Integrin alpha-V inhibitor SureCN5878455 f... 4 0
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 12


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00183634 CHEMBL389946 Bioactive SureCN14558952
CFAMM00183579 CHEMBL97944 Bioactive (E,3S)-3-[[2-[3-methoxypropyl-[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]acetyl]amino]hex-4-enoic acid
CFAMM00183640 CHEMBL1791268 Bioactive (3S)-4-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-3-[[(2S)-4-methyl-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]-4-oxobutanoic acid
CFAMM00183604 CHEMBL173699 Bioactive (3S)-4-[[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-3-[[(2S)-4-methyl-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]-4-oxobutanoic acid
CFAMM00183625 CHEMBL93656 Bioactive (2S)-2-[[(2S)-3-carboxy-2-[[(2S)-2-[[2-[4-[(2-iodophenyl)carbamoylamino]phenyl]acetyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
CFAMM00183648 CHEMBL180980 Bioactive AGN-PC-00FGUE
CFAMM00183647 CHEMBL313828 Bioactive (2R)-1-[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-4-methyl-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carboxylic acid
CFAMM00183576 CHEMBL275913 Bioactive (2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-(6-aminohexanoylamino)-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]hexanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carboxylic acid
CFAMM00183609 CHEMBL353994 Bioactive (2S)-2-[[(2S)-3-carboxy-2-[[(2S)-4-methyl-2-[[2-[4-(phenylcarbamoylamino)phenyl]acetyl]amino]pentanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
CFAMM00183670 CHEMBL184799 Bioactive 5-[[1-[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]pyrrolidine-2-carbonyl]amino]pentanoic acid
CFAMM00183566 CHEMBL159036 Bioactive 3-[[2-[cyclohexyl-[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]acetyl]amino]-3-phenylpropanoic acid
CFAMM00183669 CHEMBL369731 Bioactive AGN-PC-02YIM0
CFAMM00183556 CHEMBL360163 Bioactive AGN-PC-004ROU
CFAMM00183581 CHEMBL435153 Bioactive AGN-PC-075E5H
CFAMM00183642 CHEMBL369635 Bioactive (2S)-2-[[(2S)-3-carboxy-2-[[(2S)-4-methyl-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
CFAMM00183624 DNC000321 Investigative Drug BIO-1211

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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