CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1893
Family Name Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylbut-1-ynyl)pyridine Family
No. of Seeds 6 No. of Other Members 32
Family Centroid CFAMM00253536 Functional Category Investigative Drug
Superfamily Cathepsin S and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 2102

Cousin Family NamesSeedsMembers
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Farnesyl pyrophosphate synthase Inhibitor Piridronic Acid Family 3 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
Cathepsin S Inhibitor 6-(3-(trifluoromethyl)phenyl)picolinonit... 7 2
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2
Metabotropic glutamate receptor 5 Ligand 3-chloro-5-(2-methylq... 3 4
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Metabotropic glutamate receptor 5 ligand [18F]FDEGPECO family 5 2
Corticotropin-releasing factor receptor 1 ligand 3,7-dimethyl-... 3 4
S-adenosylmethionine decarboxylase proenzyme inhibitor 6-[(E)-... 2 6
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9UNU family 3 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SQ6 family 3 0
Corticotropin-releasing factor receptor 1 ligand 2-(2,4-dichlo... 2 2
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 1 0
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
(E,2S)-4-quinolin-2-ylbut-3-en-2-ol NP (s,e)-4-(quinolin-2-yl)... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00253558 CHEMBL415083 Bioactive 2-[2-(2-chlorophenyl)ethynyl]-6-methylpyridine
CFAMM00253543 CHEMBL245404 Bioactive SureCN4710415
CFAMM00253542 CHEMBL1255868 Bioactive MPEP hydrochloride
CFAMM00253547 DNC006849 Investigative Drug 2-(4-(3-chlorophenyl)but-1-ynyl)-6-methylpyridine
CFAMM00253530 DNC006125 Investigative Drug 2-methyl-6-(phenylethynyl)pyridine
CFAMM00253536 DNC006852 Investigative Drug 2-methyl-6-(4-phenylbut-1-ynyl)pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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