CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1902
Family Name 4-aminobutyrate aminotransferase, mitochondrial and Succinate-semialdehyde dehydrogenase, mitochondrial Inhibitor 1-(4-hydroxyphenyl)prop-2-en-1-one Family
No. of Seeds 4 No. of Other Members 22
Family Centroid CFAMM00254022 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Prothrombin and Estrogen receptor beta Binder Superfamily
Class Class 121

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Prostaglandin G/H synthase 1 Inhibitor Salicyclic Acid Family 3 39
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
Oestrogen receptor ligand Dienestrol Family 35 440
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Danthron family 11 141
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Mitogen-activated protein kinase 12 Inhibitor SCIO-469 Family 1 7
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU78299 F... 2 1
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Steryl-sulfatase Inhibitor 4-sulfamoyloxy-benzoic Acid Hexyl E... 11 1
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 2 19
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Steryl-sulfatase Inhibitor 3-{4-[(aminosulfonyl)oxy]benzoyl}ph... 5 3
Steryl-sulfatase Inhibitor Sulfamic Acid 3-(4-hydroxy-benzoyl)... 3 2
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-... 2 27
Estrogen receptor beta Ligand 3,6-dihydroxy-2-(4-hydroxy-pheny... 2 23
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,5-difluorophenyl)... 12 10
Interstitial collagenase Inhibitor N-hydroxy-4-(4-methoxy-phen... 6 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Tyrosine-protein phosphatase non-receptor type 1 Ligand Kuwano... 3 3
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor P-coum... 1 1
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-b... 6 21
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Isocitrate lyase Inhibitor Bis(3-bromo-4,5-dihydroxyphenyl)met... 1 2
Estrogen receptor beta and Estrogen receptor ligand 4-bromo-9a... 3 0
Thromboxane A2 receptor ligand AGN-PC-003UTI family 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 2
Tyrosine-protein kinase Lck inhibitor ZINC03370948 family 3 0
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Nuclear receptor ROR-gamma and Huntingtin ligand CHEMBL1568747... 1 3
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor propan... 3 5
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 2
Glutamate carboxypeptidase 2 inhibitor 2-[(3-hydroxyphenyl)met... 1 0
Catechol O-methyltransferase inhibitor 4,5-dihydroxybenzene-1,... 1 1
Eukaryotic elongation factor 2 kinase and Proto-oncogene tyros... 1 1
Benzoic Acid and Derivatives Metabolite Methyl 3-(2,3-dihydrox... 1 3
Acenes Metabolite Lacinilene C Family 2 3
1-(3,5-dihydroxyphenyl)-12-hydroxytridecan-2-one NP ZINC311562... 2 0
Putative NP ZINC49600254 Family 8 2
2,4-diacetyl-5-hydroxy-3-(4-hydroxyphenyl)-5-methylcyclohexen-... 4 0
Putative NP ZINC03197541 Family 1 0
2,4-bis(4-hydroxyphenyl)cyclobutane-1,3-dicarboxylate NP ZINC0... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00254021 DNC014326 Investigative Drug 4',4-Dihydroxychalcone
CFAMM00254019 DNC013972 Investigative Drug 3-chloro-1-(4-hydroxyphenyl)propan-1-one
CFAMM00254023 DNC006144 Investigative Drug 4-hydroxybenzaldehyde
CFAMM00254022 DNC006145 Investigative Drug 1-(4-hydroxyphenyl)prop-2-en-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27409 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543