CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1907
Family Name 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2B Ligand VER-2692 Family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00254084 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 2A and Cholinesterase Binder Superfamily
Class Class 1116

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Transient receptor potential cation channel subfamily V member... 15 158
Transient receptor potential cation channel subfamily V member... 15 457
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Reverse transcriptase Inhibitor Dapivirine Family 5 72
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Amg 423 family 7 47
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Metabotropic glutamate receptor 5 Ligand 3-(1-pyridin-2-yl-1h-... 3 6
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Mast/stem cell growth factor receptor Kit Ligand 9-bromo-5,11-... 1 0
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 6
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2
Acetylcholinesterase Inhibitor Infractopicrin Family 1 1
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Protein kinase C theta type and Protein kinase C delta type in... 16 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 3
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YYL... 1 3
Corticotropin-releasing factor receptor 1 ligand N-(cyclopropy... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Acetylcholinesterase and Cholinesterase inhibitor 3,8-DIAMINO-... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 5
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[... 5 4
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
Hepatocyte growth factor receptor ligand AGN-PC-08XYH3 family 1 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
Sodium-dependent serotonin transporter inhibitor 3-[[(3S)-1-az... 1 1
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Melanin-concentrating hormone receptor 2 ligand N,N-dimethyl-3... 2 2
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 3 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 0
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Prostaglandin D2 receptor 2 ligand SureCN317401 family 3 8
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 5 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 4
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... 1 0
Neuronal acetylcholine receptor subunit alpha-6 ligand AGN-PC-... 2 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 3 0
G-protein coupled bile acid receptor 1 ligand 1-[4-[(1R,3E)-1-... 1 1
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Glucocorticoid receptor ligand 6-benzyl-1-(4-fluorophenyl)-4a-... 2 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Androgen receptor ligand SureCN7034488 family 1 13
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Thromboxane-A synthase inhibitor AGN-PC-07BYVF family 1 0
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Histamine H3 receptor ligand AGN-PC-09M6FC family 1 9
TGF-beta receptor type-1 ligand 6-bromo-4-(2-(6-methylpyridin-... 1 3
Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... 2 1
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
Putative NP ZINC38570085 Family 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00254083 CHEMBL1084560 Bioactive SureCN1641335
CFAMM00254086 CHEMBL1082781 Bioactive SureCN1640187
CFAMM00254084 DNC006151 Investigative Drug VER-2692

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27058 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543