CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1915
Family Name Substance-P receptor Ligand SCH-388714 Family
No. of Seeds 26 No. of Other Members 8
Family Centroid CFAMM00254136 Functional Category Investigative Drug
Superfamily Substance-P receptor Ligand SCH-388714 Superfamily
Class Class 2289

Cousin Family NamesSeedsMembers
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Histamine H1 receptor Ligand Clemastine Family 5 76
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Substance-P receptor Ligand L-733060 Family 19 71
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Substance-P receptor ligand (1S,2R)-2-[(1R)-1-[3,5-bis(trifluo... 12 0
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 1 2
Substance-P receptor ligand (2S)-3-[[3,5-bis(trifluoromethyl)p... 1 4
Substance-P receptor ligand N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(tri... 1 0
Substance-P receptor ligand 1-[4-[[3,5-bis(trifluoromethyl)phe... 5 8
Substance-P receptor ligand 4-[[3,5-bis(trifluoromethyl)phenyl... 2 1
Substance-P receptor and Potassium voltage-gated channel subfa... 10 0
Substance-P receptor ligand 1-[[(1R,2R,3S)-3-[[3,5-bis(trifluo... 4 3
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Substance-P receptor ligand 1-[(1R,2S,3S)-3-[[3,5-bis(trifluor... 7 2
Substance-P receptor ligand 2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(... 5 0
Substance-P receptor ligand 1-[3-[[(1R)-1-[3,5-bis(trifluorome... 2 0
Substance-P receptor and Neuromedin-K receptor ligand 3-[[(1R)... 1 2
Substance-P receptor ligand 2-[[(1R,2S,3S)-3-[[3,5-bis(trifluo... 6 0
Substance-P receptor ligand (5R)-5-[[[(1R,2S,3S)-3-[(1R)-1-[3,... 6 0
Substance-P receptor ligand (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trif... 8 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 5 1
Substance-P receptor ligand 1-[(3S,4R)-3-[(1R)-1-[3,5-bis(trif... 9 0
Substance-P receptor ligand (5S)-5-[(3S,4R)-3-[(1R)-1-[3,5-bis... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Substance-P receptor ligand SureCN8415737 family 3 4
Substance-P receptor ligand methyl 2-[(2S,3S)-2-[[3,5-bis(trif... 1 1
Sodium-dependent dopamine transporter and Sigma non-opioid int... 2 0
Substance-P receptor and Potassium voltage-gated channel subfa... 2 0
Substance-P receptor ligand SureCN8912140 family 2 12
Substance-P receptor ligand N-[(3S,5S)-5-[[(1R)-1-[3,5-bis(tri... 10 0
Phenylalanine--tRNA ligase alpha subunit inhibitor TCMDC-14030... 1 1
(4R,5S)-4-methyl-5-phenyl-1,3-oxazolidin-2-one NP (4r,5s)-4-me... 1 4
Putative NP ZINC04026324 Family 6 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00254143 CHEMBL380931 Bioactive (4R)-4-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-1-methyl-4-phenylimidazolidin-2-one
CFAMM00254163 CHEMBL381151 Bioactive (4R)-4-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-4-(4-fluorophenyl)imidazolidin-2-one
CFAMM00254142 CHEMBL204714 Bioactive AGN-PC-03WMX6
CFAMM00254155 CHEMBL1270272 Bioactive [(3S,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]urea
CFAMM00254162 CHEMBL381524 Bioactive (4R)-4-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-4-phenyl-1-propan-2-ylimidazolidin-2-one
CFAMM00254141 CHEMBL428933 Bioactive (3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)-N-methylpyrrolidine-1-carboxamide
CFAMM00254154 CHEMBL204306 Bioactive (4R)-4-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-4-phenylimidazolidin-2-one
CFAMM00254134 CHEMBL203716 Bioactive AGN-PC-03WMX5
CFAMM00254160 CHEMBL222976 Bioactive SureCN13945833
CFAMM00254140 CHEMBL270090 Bioactive (6R,7S,7aR)-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-7-(4-fluorophenyl)-1,2,5,6,7,7a-hexahydropyrrolo[1,2-c]imidazol-3-one
CFAMM00254153 CHEMBL1270370 Bioactive 1-[(3S,6S)-6-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-6-phenylpiperidin-3-yl]imidazolidin-2-one
CFAMM00254167 CHEMBL379038 Bioactive 4-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-4-(4-fluorophenyl)-1-piperidin-4-ylimidazolidin-2-one
CFAMM00254133 CHEMBL84588 Bioactive (2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpyrrolidine
CFAMM00254159 CHEMBL249568 Bioactive (3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)-N,N-dimethylpyrrolidine-1-carboxamide
CFAMM00254139 CHEMBL204554 Bioactive (4R)-4-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-4-(4-fluorophenyl)imidazolidin-2-one
CFAMM00254152 CHEMBL204206 Bioactive AGN-PC-075ZSA
CFAMM00254166 CHEMBL203753 Bioactive (4R)-4-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-1-ethyl-4-phenylimidazolidin-2-one
CFAMM00254145 CHEMBL382771 Bioactive (4R)-4-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-4-(4-fluorophenyl)-1-methylimidazolidin-2-one
CFAMM00254158 CHEMBL425406 Bioactive 2-[(4R)-4-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-4-(4-fluorophenyl)-2-oxoimidazolidin-1-yl]acetamide
CFAMM00254138 CHEMBL251387 Bioactive (3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-N-ethyl-4-(4-fluorophenyl)pyrrolidine-1-carboxamide
CFAMM00254151 CHEMBL398720 Bioactive (3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)-N-propan-2-ylpyrrolidine-1-carboxamide
CFAMM00254144 CHEMBL398919 Bioactive (3S,4R)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-N-tert-butyl-4-(4-fluorophenyl)pyrrolidine-1-carboxamide
CFAMM00254137 CHEMBL204296 Bioactive 4-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-4-(4-fluorophenyl)-1-(oxan-4-yl)imidazolidin-2-one
CFAMM00254150 CHEMBL203740 Bioactive (4R)-4-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-1-ethyl-4-(4-fluorophenyl)imidazolidin-2-one
CFAMM00254164 CHEMBL270114 Bioactive (6R,7S,7aR)-2-benzyl-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-7-(4-fluorophenyl)-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazol-3-one
CFAMM00254136 DNC006193 Investigative Drug SCH-388714

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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