CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1916
Family Name Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibitor 3,4-di-(4-methoxyphenyl)-1h-pyrrole-2,5-dione Family
No. of Seeds 2 No. of Other Members 10
Family Centroid CFAMM00254175 Functional Category Investigative Drug with Natural Product
Superfamily Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibitor 3,4-di-(4-methoxyphenyl)-1h-pyrrole-2,5-dione Superfamily
Class Class 2290

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Muscarinic acetylcholine receptor M3 Ligand Darifenacin Family 3 17
Zucapsacin family 7 177
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand DA-5018 Family 14 73
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 4 42
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Neutrophil elastase and Urokinase-type plasminogen activator I... 1 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor S-[3-(4-m... 1 2
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Sodium-dependent serotonin transporter and Transporter inhibit... 2 2
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 4
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Histamine H1 receptor and Histamine H3 receptor ligand 4-[(4-m... 3 6
Sigma non-opioid intracellular receptor 1 ligand methyl (1R,2S... 4 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 1
Histamine H3 receptor ligand 1-methyl-5-[4-[3-[(2R)-2-methylpy... 5 5
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 12
Solute carrier family 12 member 5 inhibitor AGN-PC-07ZCLM family 1 12
Kappa-type opioid receptor ligand 1-[4-acetyl-2-[[(3S)-3-hydro... 1 0
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor AGN-PC-07... 2 6
C-C chemokine receptor type 2 ligand (E)-N-[(1S,3R)-3-[[4-(4-m... 1 6
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Dipeptidyl peptidase 4 inhibitor 3-[[2-[(2S,4S)-2-cyano-4-fluo... 5 1
Transient receptor potential cation channel subfamily V member... 1 0
Reverse transcriptase/RNaseH inhibitor Thiazoloisoindol-5-one ... 1 2
Lysosomal alpha-glucosidase inhibitor MLS000587024 family 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-000I3M family 2 6
Arachidonate 5-lipoxygenase inhibitor AGN-PC-074BAX family 1 0
N-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-4-(4-methoxyphenyl)te... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00254176 DNC006197 Investigative Drug 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione
CFAMM00254175 DNC006195 Investigative Drug 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27285 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543