CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1922
Family Name Sodium-dependent dopamine transporter and Sodium-dependent noradrenaline transporter Inhibitor 1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one Family
No. of Seeds 10 No. of Other Members 28
Family Centroid CFAMM00254258 Functional Category Investigative Drug
Superfamily Sodium-dependent dopamine transporter and Sodium-dependent noradrenaline transporter Inhibitor 1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one Superfamily
Class Class 2294

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Noradrenergic re-uptake and Serotonin re-uptake inhibitor phen... 18 41
Opioid receptor Ligand Methadone Family 3 39
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
DNA Binder Procarbazine Family 8 358
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Chymase Inhibitor Phenylalanylmethane Family 1 8
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 4 10
Thyroid hormone receptor beta Ligand 1-(4-hexylphenyl)-3-(prop... 2 1
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Sodium-dependent dopamine transporter and Sodium-dependent nor... 4 1
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 18
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
5-hydroxytryptamine receptor 1A ligand U93385 family 4 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 4
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[[... 2 10
Melanin-concentrating hormone receptor 1 ligand 1-(3-acetyl-1,... 8 4
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-(4-oxo-4-ph... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 7 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 11 2
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
5-hydroxytryptamine receptor 1A ligand [(7S,8R)-7-(dipropylami... 4 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 5
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Lanosterol synthase and Cycloartenol synthase inhibitor (4-bro... 1 2
5-hydroxytryptamine receptor 1A ligand 8-[4-[[(2R)-8-acetyl-5-... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TEL... 1 7
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 1 1
C-C chemokine receptor type 3 ligand AGN-PC-07C4A5 family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00254238 CHEMBL87348 Bioactive 1-[(7R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-yl]ethanone
CFAMM00254256 CHEMBL134651 Bioactive SureCN8822548
CFAMM00254255 CHEMBL135033 Bioactive [(7R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-yl]-phenylmethanone
CFAMM00254268 CHEMBL87195 Bioactive 1-[(7S)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-yl]ethanone
CFAMM00254261 CHEMBL286250 Bioactive 140221-50-7
CFAMM00254258 DNC006219 Investigative Drug 1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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