CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1926
Family Name Cathepsin B and Cathepsin K Inhibitor (s)-1-benzylcyclopentyl 1-oxohexan-2-ylcarbamate Family
No. of Seeds 11 No. of Other Members 5
Family Centroid CFAMM00254388 Functional Category Investigative Drug
Superfamily Cathepsin B and Cathepsin K Inhibitor (s)-1-benzylcyclopentyl 1-oxohexan-2-ylcarbamate Superfamily
Class Class 23

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Tyrosine 3-monooxygenase Inhibitor L-phenylalanine Family 19 144
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Flovagatran family 12 546
Prothrombin Inhibitor Efegatran Family 9 47
Neprilysin Inhibitor Thiorphan Family 41 68
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cruzipain Inhibitor WRR-204 Family 18 35
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-lle-agly-ile-v... 17 7
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Epidermal growth factor receptor Ligand (s)-benzyl 4-chloro-3-... 1 0
Cytosolic phospholipase A2 Inhibitor Methyl 2-(2-oxo-8-phenylo... 2 3
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Prolyl endopeptidase and Chymotrypsin-like elastase family mem... 3 9
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Cathepsin K inhibitor [(3R)-4,4-dimethyl-1-phenylpentan-3-yl] ... 7 7
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 0
Chymase and Chymotrypsinogen B inhibitor AGN-PC-075LTI family 2 3
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 5
Transcriptional activator protein LuxR inhibitor 3-(3-iodophen... 8 2
N-[(4S)-2,2-dimethyloxan-4-yl]-4-methyl-3-phenylpentanamide NP... 4 0
Putative NP ZINC12898297 Family 2 0


External ID

Functional Category

Molecule Name

CFAMM00254380 CHEMBL116724 Bioactive (1-benzylcyclobutyl) N-[(2S)-1-oxohexan-2-yl]carbamate
CFAMM00254386 CHEMBL117144 Bioactive (1-benzylcyclohexyl) N-[(2S)-1-oxohexan-2-yl]carbamate
CFAMM00254389 CHEMBL114904 Bioactive [(2S)-4-methyl-1-phenylpentan-2-yl] N-[(2S)-1-oxohexan-2-yl]carbamate
CFAMM00254379 CHEMBL324986 Bioactive [1-(2-chlorophenyl)-2-methylpropan-2-yl] N-[(2S)-1-oxohexan-2-yl]carbamate
CFAMM00254385 CHEMBL117149 Bioactive [1-(4-chlorophenyl)-2-methylpropan-2-yl] N-[(2S)-1-oxohexan-2-yl]carbamate
CFAMM00254383 CHEMBL114844 Bioactive [(2S)-1-phenylpentan-2-yl] N-[(2S)-1-oxohexan-2-yl]carbamate
CFAMM00254388 DNC006243 Investigative Drug (S)-1-benzylcyclopentyl 1-oxohexan-2-ylcarbamate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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