CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1928
Family Name Delta-type opioid receptor and Gastrin/cholecystokinin type B receptor Ligand H-tyr-d-ala-gly-phe-nh-nh-phe-asp-nle-trp-ac Family
No. of Seeds 19 No. of Other Members 0
Family Centroid CFAMM00254409 Functional Category Investigative Drug
Superfamily peptide hormone ligand peptide Ceruletide Lanreotide Superfamily
Class Class 85

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Gonadotropin-releasing hormone receptor Ligand decapeptide ana... 9 162
Epidermal Growth Factor family 111 209
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Insulin receptor Ligand Insulin, Porcine Family 61 205
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
HIV-1 protease Inhibitor Atazanavir Family 16 58
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
CBP-501 family 7 8
AEZS-108 family 5 2
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Renin Inhibitor Enalkiren Family 56 44
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 0
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(1,2-dimethylindol-3-yl... 3 4
Caspase-1 inhibitor (3S)-4-oxo-3-[[(2S)-4-oxo-2-propan-2-yl-4-... 3 0
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 4 0
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Histone deacetylase inhibitor (3S,6S,9S,12R)-3-[(2S)-butan-2-y... 1 0
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
KiSS-1 receptor ligand (2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-... 3 0
Pancreatic alpha-amylase and Gastrin/cholecystokinin type B re... 7 1
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN6786541 f... 3 6
Beta-2 adrenergic receptor ligand SureCN5346426 family 8 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 4
Gonadotropin-releasing hormone receptor ligand (3S)-3-[[(2R)-2... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Growth hormone secretagogue receptor type 1 ligand N-[(1R)-2-(... 3 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Vasopressin V2 receptor and Vasopressin V1a receptor ligand 2-... 1 26
Coagulation factor VII inhibitor CHEMBL269354 family 1 0
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
Growth factor receptor-bound protein 2 ligand 2-[4-[(2S)-3-[[1... 1 0
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 1
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Substance-P receptor ligand SureCN2139814 family 7 7
Endothelin B receptor and Endothelin-1 receptor ligand N-[(2R)... 12 3
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 1 0
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-08866Z fa... 2 0
E3 ubiquitin-protein ligase Mdm2 and Protein Mdm4 inhibitor CH... 2 1
Phospho-N-acetylmuramoyl-pentapeptide-transferase inhibitor (2... 1 1
Lutropin-choriogonadotropic hormone receptor ligand 5-[2-(4-te... 1 1
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00254411 CHEMBL430298 Bioactive (3S)-3-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(1H-indol-3-yl)propanoyl]-methylamino]hexanoyl]amino]-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
CFAMM00254415 CHEMBL437661 Bioactive (3S)-4-[[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-2-[[(2R,5S,8S,15R)-5-butyl-2-[(4-hydroxyphenyl)methyl]-15-[(2-methylpropan-2-yl)oxycarbonylamino]-3,6,14,18-tetraoxo-1,4,7,13-tetrazacyclooctadecane-8-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoyl]amino]-4-oxobutanoic acid
CFAMM00254414 DNC006257 Investigative Drug H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-D-Trp-Boc
CFAMM00254407 DNC007061 Investigative Drug H-Tyr-D-Ala-Gly-Phe-NH-NH-Trp-D-Nle-D-Asp-D-Phe-H
CFAMM00254413 DNC006258 Investigative Drug H-Tyr-D-Ala-Gly-Phe-NH-NH-(NMe)Phe-Asp-Nle-Trp-Ac
CFAMM00254406 DNC007062 Investigative Drug H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-Bo
CFAMM00254412 DNC006259 Investigative Drug Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-NMeNle-D-Trp-Boc
CFAMM00254405 DNC007063 Investigative Drug H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Phe-D-Asp-D-Nle-Trp-H
CFAMM00254410 DNC006261 Investigative Drug H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-Trp-Boc
CFAMM00254409 DNC006260 Investigative Drug H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-Trp-Ac
CFAMM00254408 DNC007060 Investigative Drug H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-H

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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