CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID1929
Family Name Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[nle-gln-d-nal(2')-arg-trp-glu]-nh2 Family
No. of Seeds 12 No. of Other Members 10
Family Centroid CFAMM00254426 Functional Category Investigative Drug with Natural Product
Superfamily Melanocortin receptor 3 and Melanocortin receptor 4 Binder Superfamily
Class Class 147

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Alpha adrenergic receptor ligand ergot alkaloid Dihydroergota... 7 12
Epidermal Growth Factor family 111 209
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Prothrombin Inhibitor Ximelegatran Family 8 157
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Transient receptor potential cation channel subfamily V member... 15 158
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Substance-P receptor Ligand TAK-637 Family 18 63
NS5A protein Inhibitor Bms 790052 Family 5 9
BIBT986 family 7 96
CBP-501 family 7 8
ABC294640 family 5 75
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
Gonadotropin-releasing hormone Inhibitor ASP3550 Family 33 60
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
Class II cytokine receptor Ligand IL-10 Family 7 45
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Cyclin-dependent kinase 1 and G2/mitotic-specific cyclin-B1 In... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Gonadotropin-releasing hormone receptor Ligand Azaline B Family 12 0
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Gonadotropin-releasing hormone receptor Ligand [d-ncy(methyl)4... 32 0
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Cycl... 7 6
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Pol polyprotein inhibitor penicillin deriv. 40 family 2 4
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 2 14
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Cathepsin K inhibitor [(3S)-1-(1H-indole-6-carbonyl)-4,4-dimet... 2 4
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Prolyl endopeptidase inhibitor [(2S,3aS,7aS)-2-(pyrrole-1-carb... 2 0
Histone deacetylase 3 and Histone deacetylase 6 inhibitor Tria... 20 37
Calcitonin gene-related peptide type 1 receptor ligand CHEMBL1... 5 8
Cholecystokinin receptor type A ligand A-65186 family 2 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Pol polyprotein inhibitor N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydr... 2 0
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 0
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(1,2-dimethylindol-3-yl... 3 4
Caspase-1 inhibitor (3S)-4-oxo-3-[[(2S)-4-oxo-2-propan-2-yl-4-... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 4 0
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Cathepsin K inhibitor SureCN2155973 family 3 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 3
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... 2 1
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 10 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 0
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Dipeptidyl peptidase 4 inhibitor (2S)-1-[2-[5-(aminomethyl)-2-... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Glycogen synthase kinase-3 beta and Tyrosine-protein kinase JA... 1 0
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 5 1
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Baculoviral IAP repeat-containing protein 2 and Baculoviral IA... 1 0
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Cytochrome P450 2D6 and Cytochrome P450 2C19 inhibitor Demethy... 1 4
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[2-(1H-ind... 1 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Cathepsin L1 and Cathepsin S inhibitor N-[(2S)-4-methyl-1-oxo-... 3 3
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Relaxin-3 receptor 1 and Relaxin-3 receptor 2 ligand CHEMBL203... 4 1
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Growth hormone secretagogue receptor type 1 ligand SureCN36660... 4 14
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Pancreatic alpha-amylase and Gastrin/cholecystokinin type B re... 7 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Prostaglandin D2 receptor 2 ligand 2-[(3R)-3-(3,3-diphenylprop... 1 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Coagulation factor X and Prothrombin inhibitor SureCN8243313 f... 10 8
Coagulation factor X and Prothrombin inhibitor SureCN8237487 f... 16 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 2 0
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Translocator protein inhibitor CHEMBL2331870 family 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Motilin receptor ligand SureCN2768052 family 3 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 4
Gonadotropin-releasing hormone receptor ligand (3S)-3-[[(2R)-2... 1 0
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 1
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 8
Somatostatin receptor type 5 ligand L-817,818 family 2 0
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 4 11
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
Gonadotropin-releasing hormone receptor ligand (3S)-3-[[(2S)-2... 5 0
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Proteinase-activated receptor 1 and Prothrombin ligand (2S)-N-... 3 23
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 3 0
Protein kinase C delta type and Protein kinase C beta type inh... 4 4
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Endothelin B receptor and Endothelin-1 receptor ligand 2-[[(2R... 17 10
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 2 0
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
Growth factor receptor-bound protein 2 ligand 2-[4-[(2S)-3-[[1... 1 0
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Neprilysin and Endothelin-converting enzyme 1 inhibitor (2S)-2... 5 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Neutrophil collagenase and Interstitial collagenase inhibitor ... 1 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
KiSS-1 receptor ligand SureCN5132924 family 2 4
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
C-X-C chemokine receptor type 2 and Cytochrome P450 2C9 ligand... 1 7
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Angiotensin-converting enzyme inhibitor AC1L1IZN family 2 2
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 1 0
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Melanocortin receptor 3 and Melanocyte-stimulating hormone rec... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN14185127 f... 2 0
Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... 3 5
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Interstitial collagenase and Stromelysin-1 inhibitor CHEMBL887... 1 0
Substance-P receptor ligand methyl 6-acetamido-3-[[(2S)-1-[[3,... 1 0
Receptor-interacting serine/threonine-protein kinase 1 ligand ... 1 11
Histone deacetylase 1 and Histone deacetylase 2 inhibitor (2S)... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 48
Coagulation factor X inhibitor (3R,4R)-3-N-[2-fluoro-4-(2-oxop... 1 0
Cytochrome P450 2C19 and Cytochrome P450 3A4 inhibitor (E)-3-[... 4 0
Calcium/calmodulin-dependent protein kinase type II subunit de... 1 0
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0
Proto-oncogene Wnt-3 inhibitor CHEMBL563202 family 2 0
2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(1... 3 0
6-(3-nitrophenyl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyri... 16 0
NP Agn-pc-099dao Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00254416 CHEMBL2170779 Bioactive (2S)-2,6-diamino-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]hexanamide
CFAMM00254422 CHEMBL2170781 Bioactive (2S)-2,6-diamino-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-naphthalen-1-yl-1-oxopropan-2-yl]hexanamide
CFAMM00254425 DNC006266 Investigative Drug c[Nle-Val-D-Nal(2')-Arg-Trp-Glu]-NH2
CFAMM00254424 DNC006271 Investigative Drug c[Nle-Glu-D-Nal(2')-Arg-Trp-Glu]-NH2
CFAMM00254423 DNC008090 Investigative Drug c[CO-(CH2)2-CO-Nle-D-Nal(2)-Arg-Trp-Lys]-NH2
CFAMM00254426 DNC006268 Investigative Drug c[Nle-Gln-D-Nal(2')-Arg-Trp-Glu]-NH2

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24503 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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