CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1934
Family Name Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-trione Family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00254632 Functional Category Investigative Drug with Natural Product
Superfamily Caspase-3 and Histamine H3 receptor Binder Superfamily
Class Class 893

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 3
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Lethal(3)malignant brain tumor-like protein 1 and Lysine-speci... 1 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[(... 5 2
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[(... 2 0
Sigma non-opioid intracellular receptor 1 and Vesicular acetyl... 3 7
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 3 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
C-C chemokine receptor type 5 ligand 4-[4-[[4-[(5R)-3-cyclohex... 4 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
Mitogen-activated protein kinase 8 inhibitor methyl 6-bromo-2-... 6 3
Reverse transcriptase/RNaseH inhibitor Thiazoloisoindol-5-one ... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00254632 DNC006287 Investigative Drug 2-(4-methoxy-benzyl)isoquinoline-1,3,4-trione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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