CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1939
Family Name Amyloid beta A4 protein Inhibitor 2,5-bis(4-methoxyphenyl)thiophene Family
No. of Seeds 3 No. of Other Members 31
Family Centroid CFAMM00254671 Functional Category Investigative Drug
Superfamily Amyloid beta A4 protein Inhibitor 2,5-bis(4-methoxyphenyl)thiophene Superfamily
Class Class 2300

Cousin Family NamesSeedsMembers
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3'-(1-benzothien-2... 3 33
Cytochrome P450 1B1 Inhibitor 2-[2-(3,5-dimethoxy-phenyl)-viny... 2 2
Collagenase 3 and Interstitial collagenase Inhibitor 3-(4-meth... 12 76
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-[5-(4-hydroxyphe... 21 16
Androgen receptor Ligand 4-(isopropylthio)-2-methoxybenzonitri... 9 3
Aromatase Inhibitor NSC-122427 Family 1 0
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3'-(5-chloro-2-thi... 3 2
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 5 18
Carbonic anhydrase 2 inhibitor (2-sulfamoyl-1-benzothiophen-6-... 3 4
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 12 10
Sodium/glucose cotransporter 2 inhibitor (2R,3R,4S,5S,6R)-2-[4... 2 5
Sigma non-opioid intracellular receptor 1 ligand 1'-benzyl-6-m... 4 2
Carbonic anhydrase 2 inhibitor 6-hydroxy-1-benzothiophene-2-su... 2 3
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 0
DNA-(apurinic or apyrimidinic site) lyase and Phospholipase A2... 1 4
Progesterone receptor ligand 6-(5-chlorothiophen-2-yl)chromen-... 1 1


External ID

Functional Category

Molecule Name

CFAMM00254671 DNC006305 Investigative Drug 2,5-bis(4-methoxyphenyl)thiophene
CFAMM00254670 DNC006303 Investigative Drug 4-(5-(4-methoxyphenyl)thiophen-2-yl)phenol
CFAMM00254640 DNC006297 Investigative Drug 2,5-bis(2-methoxyphenyl)thiophene

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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