CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1949
Family Name Disintegrin and metalloproteinase domain-containing protein 17 and Collagenase 3 Inhibitor TMI-05 Family
No. of Seeds 82 No. of Other Members 411
Family Centroid CFAMM00255332 Functional Category Investigative Drug
Superfamily Disintegrin and metalloproteinase domain-containing protein 17 and Collagenase 3 Inhibitor TMI-05 Superfamily
Class Class 2303

Cousin Family NamesSeedsMembers
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 15 129
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 3 28
Disintegrin and metalloproteinase domain-containing protein 17... 25 33
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 7
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 6 16
Matrix metalloproteinase-9 and Collagenase 3 inhibitor 4-benzy... 10 32
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 13
Disintegrin and metalloproteinase domain-containing protein 17... 10 39
Collagenase 3 and Interstitial collagenase inhibitor N-hydroxy... 8 4
Collagenase 3 and Interstitial collagenase inhibitor AGN-PC-01... 10 1
Cathepsin K inhibitor SureCN6578603 family 1 3
Collagenase 3 and Interstitial collagenase inhibitor (1R,5S)-3... 2 1
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor AC1L4BQ... 3 0
Pol polyprotein inhibitor morpholinone scaffold 1 family 5 29
Leukotriene A-4 hydrolase inhibitor 3-[3-(4-benzylphenoxy)prop... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor N-hydro... 3 0
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 4-acety... 9 4
Collagenase 3 and Matrix metalloproteinase-9 inhibitor (4R)-N-... 13 4
Pol polyprotein inhibitor benzyl (2S)-2-[[[(2S)-3-[cyclopentyl... 2 6
Collagenase 3 and Stromelysin-1 inhibitor 1-N-benzyl-3-N-hydro... 7 15
Matrix metalloproteinase-9 and Collagenase 3 inhibitor N-hydro... 2 1
Matrix metalloproteinase-9 and Collagenase 3 inhibitor AGN-PC-... 7 12
Lethal(3)malignant brain tumor-like protein 1 inhibitor CHEMBL... 1 5
Neutrophil collagenase and Stromelysin-1 inhibitor 7-[[(2S)-2-... 10 9
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075O... 14 27
Collagenase 3 and 72 kDa type IV collagenase inhibitor (5R)-N-... 7 0
Neutrophil collagenase inhibitor (3R)-2-[4-[4-(dimethylamino)p... 2 4
72 kDa type IV collagenase and Collagenase 3 inhibitor (2R)-1-... 25 6
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R,4S)... 7 1
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R,4S)... 14 0
Collagenase 3 and Stromelysin-1 inhibitor (2R,4S)-N-hydroxy-4-... 7 0
72 kDa type IV collagenase and Collagenase 3 inhibitor (2R,4S)... 3 0
Matrix metalloproteinase-15 and Matrix metalloproteinase-16 in... 1 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R,4Z)... 17 0
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 26 12
Disintegrin and metalloproteinase domain-containing protein 17... 4 2
Macrophage metalloelastase and 72 kDa type IV collagenase inhi... 7 4
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor AGN-PC-... 3 5
Collagenase 3 and 72 kDa type IV collagenase inhibitor AGN-PC-... 3 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 19 11
Disintegrin and metalloproteinase domain-containing protein 17... 6 12
72 kDa type IV collagenase and Collagenase 3 inhibitor 1-ethyl... 11 5
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 3 15
Disintegrin and metalloproteinase domain-containing protein 17... 5 2
Matrix metalloproteinase-9 and Collagenase 3 inhibitor 4-[4-(1... 5 0
Collagenase 3 and Disintegrin and metalloproteinase domain-con... 4 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 25 5
Collagenase 3 and 72 kDa type IV collagenase inhibitor 4-(4-ch... 7 6
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 4 6
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 0
Collagenase 3 and Neutrophil collagenase inhibitor (3R)-1-hydr... 1 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 3 0
Interstitial collagenase inhibitor AGN-PC-075XO4 family 1 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 6 5
Disintegrin and metalloproteinase domain-containing protein 17... 6 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 16
Disintegrin and metalloproteinase domain-containing protein 17... 12 1
Disintegrin and metalloproteinase domain-containing protein 17... 9 3
Disintegrin and metalloproteinase domain-containing protein 17... 3 3
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-[(4-b... 3 1
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Macrophage metalloelastase and Collagenase 3 inhibitor N-hydro... 2 3
Macrophage metalloelastase and Collagenase 3 inhibitor (2S)-N-... 2 2
72 kDa type IV collagenase and Disintegrin and metalloproteina... 5 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 5 4
Matrix metalloproteinase-9 and Collagenase 3 inhibitor 1-hydro... 1 1
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-benzy... 13 3
Bone morphogenetic protein 1 inhibitor (2R)-2-[1,3-benzodioxol... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Disintegrin and metalloproteinase domain-containing protein 17... 13 1
Neutrophil elastase inhibitor 1-[(2S)-2-[(4-methoxyphenyl)sulf... 2 11
Neutrophil elastase inhibitor 2-[3-[(4-methoxyphenyl)sulfonyla... 1 0
Macrophage metalloelastase and 72 kDa type IV collagenase inhi... 4 4
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 0
72 kDa type IV collagenase inhibitor N-hydroxy-N-[1-[4-[4-(tri... 3 2
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-benzy... 6 2
Collagenase 3 and Matrix metalloproteinase-9 inhibitor N-hydro... 3 1
Matrix metalloproteinase-9 and Collagenase 3 inhibitor 4-[4-[(... 5 1
Neutrophil collagenase and Interstitial collagenase inhibitor ... 3 0
72 kDa type IV collagenase and Collagenase 3 inhibitor AGN-PC-... 3 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor 3-cyclo... 5 0
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-acety... 6 7
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 4
72 kDa type IV collagenase and Collagenase 3 inhibitor AGN-PC-... 3 2
72 kDa type IV collagenase and Collagenase 3 inhibitor 2-[[2-(... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor AGN-PC-... 4 0
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 0
Interstitial collagenase and Matrix metalloproteinase-9 inhibi... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(3S)-2... 2 2
72 kDa type IV collagenase and Collagenase 3 inhibitor AGN-PC-... 1 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[2-(3-methoxyp... 1 0
Bone morphogenetic protein 1 inhibitor (2R)-2-[(4-bromophenyl)... 1 4
Bone morphogenetic protein 1 inhibitor N-hydroxy-3-[[4-[(Z)-N'... 1 1
Collagenase 3 and Interstitial collagenase inhibitor 2-(4-brom... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00255392 CHEMBL141451 Bioactive (3R)-N-hydroxy-4-(4-methoxyphenyl)sulfonyl-3-methyl-1,4-thiazepane-3-carboxamide
CFAMM00255093 CHEMBL104021 Bioactive 4-benzylsulfonyl-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]butanamide
CFAMM00255245 CHEMBL356079 Bioactive (2R,4S)-4-(1,1-dioxo-1,4-thiazinan-4-yl)-N-hydroxy-1-(4-methoxyphenyl)sulfonylpyrrolidine-2-carboxamide
CFAMM00255320 CHEMBL236806 Bioactive AGN-PC-04SS9M
CFAMM00255259 CHEMBL206298 Bioactive (3S)-4-(4-hept-2-ynoxyphenyl)sulfonyl-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
CFAMM00255032 CHEMBL139884 Bioactive (3S)-4-(4-butoxyphenyl)sulfonyl-N-hydroxy-2,2-dimethyl-1,4-thiazepane-3-carboxamide
CFAMM00255372 CHEMBL441177 Bioactive (3S)-N-hydroxy-2,2-dimethyl-4-(4-pent-4-ynoxyphenyl)sulfonylthiomorpholine-3-carboxamide
CFAMM00255209 CHEMBL196092 Bioactive 4-(4-but-2-ynoxyphenyl)sulfonyl-N-hydroxymorpholine-3-carboxamide
CFAMM00255224 CHEMBL440945 Bioactive (3S)-N-hydroxy-2,2-dimethyl-4-(4-penta-2,4-diynoxyphenyl)sulfonylthiomorpholine-3-carboxamide
CFAMM00255217 CHEMBL382975 Bioactive AC1O43QI
CFAMM00254976 CHEMBL342172 Bioactive (6S)-N-hydroxy-7-(4-methoxyphenyl)sulfonyl-5,5-dimethyl-1,4,7-oxathiazonane-6-carboxamide
CFAMM00255339 CHEMBL2064545 Bioactive (2R)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-prop-2-ynylamino]-3-methylbutanamide
CFAMM00255038 CHEMBL250708 Bioactive 3-[(4-but-2-ynoxyphenyl)sulfonylmethyl]-N-hydroxy-1-propan-2-ylsulfonylpiperidine-3-carboxamide
CFAMM00255112 CHEMBL1914483 Bioactive (2R)-2-[2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl(3-methylbutyl)amino]-N-hydroxy-3-methylbutanamide
CFAMM00255138 CHEMBL345054 Bioactive N-hydroxy-4-(4-methoxyphenyl)sulfonylthiomorpholine-3-carboxamide
CFAMM00255244 CHEMBL391880 Bioactive AGN-PC-0768KO
CFAMM00255078 CHEMBL207776 Bioactive (3S)-N-hydroxy-2,2-dimethyl-4-(4-prop-2-ynoxyphenyl)sulfonylthiomorpholine-3-carboxamide
CFAMM00255391 CHEMBL203886 Bioactive (3S)-4-[4-(7-aminohept-2-ynoxy)phenyl]sulfonyl-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
CFAMM00255258 CHEMBL437499 Bioactive tert-butyl N-[4-[4-[(3S)-3-(hydroxycarbamoyl)-2,2-dimethylthiomorpholin-4-yl]sulfonylphenoxy]but-2-ynyl]carbamate
CFAMM00255223 CHEMBL2425935 Bioactive (2R)-2-[2-azidoethyl-[4-(2-fluoroethoxy)phenyl]sulfonylamino]-N-hydroxy-3-methylbutanamide
CFAMM00255285 CHEMBL381505 Bioactive tert-butyl N-[7-[4-[(3S)-3-(hydroxycarbamoyl)-2,2-dimethylthiomorpholin-4-yl]sulfonylphenoxy]hept-5-ynyl]carbamate
CFAMM00254982 CHEMBL385821 Bioactive AGN-PC-071JB8
CFAMM00254995 CHEMBL45162 Bioactive (2S)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]-4-[(4-phenylmethoxyphenyl)methylsulfanyl]butanamide
CFAMM00255058 CHEMBL206155 Bioactive tert-butyl N-[6-[4-[(3S)-3-(hydroxycarbamoyl)-2,2-dimethylthiomorpholin-4-yl]sulfonylphenoxy]hex-4-ynyl]carbamate
CFAMM00255024 CHEMBL436205 Bioactive (3S)-4-(4-butoxyphenyl)sulfonyl-N-hydroxy-2,2-dimethyl-1,1-dioxo-1,4-thiazepane-3-carboxamide
CFAMM00255098 CHEMBL337594 Bioactive (3S)-N-hydroxy-6-(methoxymethoxy)-4-(4-methoxyphenyl)sulfonyl-2,2-dimethyl-1,4-thiazepane-3-carboxamide
CFAMM00254935 CHEMBL383079 Bioactive (3S)-4-[4-[(E)-but-2-enoxy]phenyl]sulfonyl-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
CFAMM00255312 CHEMBL1090284 Bioactive (2R)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]-3-methylbutanamide
CFAMM00255137 CHEMBL214287 Bioactive AGN-PC-044FME
CFAMM00255077 CHEMBL381163 Bioactive 2-[(2S,5S)-4-(4-but-2-ynoxyphenyl)sulfonyl-5-(hydroxycarbamoyl)-6,6-dimethylthiomorpholin-2-yl]acetic acid
CFAMM00255271 CHEMBL372908 Bioactive methyl 4-(4-but-2-ynoxyphenyl)sulfonyl-3-(hydroxycarbamoyl)piperazine-1-carboxylate
CFAMM00255284 CHEMBL234143 Bioactive 4-[(4-but-2-ynoxyphenyl)sulfonylmethyl]-1-(cyclohexylmethylsulfonyl)-N-hydroxypiperidine-4-carboxamide
CFAMM00255357 CHEMBL421932 Bioactive (6S)-N-hydroxy-7-(4-methoxyphenyl)sulfonyl-5,5-dimethyl-4,4-dioxo-1,4,7-oxathiazonane-6-carboxamide
CFAMM00255130 CHEMBL320402 Bioactive (2R)-4-benzylsulfanyl-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]butanamide
CFAMM00254974 CHEMBL344828 Bioactive (3S)-N-hydroxy-4-[4-(2-methoxyethoxy)phenyl]sulfonyl-2,2-dimethyl-1,4-thiazepane-3-carboxamide
CFAMM00255290 CHEMBL207729 Bioactive (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE
CFAMM00255242 CHEMBL341570 Bioactive (3S,6R)-N,6-dihydroxy-4-(4-methoxyphenyl)sulfonyl-2,2-dimethyl-1,1-dioxo-1,4-thiazepane-3-carboxamide
CFAMM00255330 CHEMBL342248 Bioactive (3S)-N-hydroxy-4-(4-methoxyphenyl)sulfonyl-2,2-dimethyl-1,1-dioxo-1,4-thiazinane-3-carboxamide
CFAMM00254980 CHEMBL202839 Bioactive 4NH
CFAMM00255103 CHEMBL105279 Bioactive N-hydroxy-4-[(3-methoxyphenyl)methylsulfanyl]-2-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]butanamide
CFAMM00255256 CHEMBL380439 Bioactive (3S)-4-(4-butoxyphenyl)sulfonyl-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
CFAMM00254993 CHEMBL425783 Bioactive 4-[(4-but-2-ynoxyphenyl)sulfonylmethyl]-1-[4-(dimethylamino)butanoyl]-N-hydroxypiperidine-4-carboxamide
CFAMM00254959 CHEMBL140568 Bioactive N-hydroxy-4-(4-methoxyphenyl)sulfonyl-1,4-thiazepane-3-carboxamide
CFAMM00255323 CHEMBL234351 Bioactive 4-[(4-but-2-ynoxyphenyl)sulfonylmethyl]-1-cyclopentylsulfonyl-N-hydroxypiperidine-4-carboxamide
CFAMM00255336 CHEMBL144176 Bioactive (2R,4S)-1-(4-butoxyphenyl)sulfonyl-4-(1,1-dioxo-1,4-thiazinan-4-yl)-N-hydroxypyrrolidine-2-carboxamide
CFAMM00255408 CHEMBL296911 Bioactive (2S)-4-benzylsulfanyl-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]butanamide
CFAMM00255000 CHEMBL383028 Bioactive (3S)-4-[4-(6-aminohex-2-ynoxy)phenyl]sulfonyl-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
CFAMM00255329 CHEMBL140575 Bioactive N-hydroxy-1-(4-methoxyphenyl)sulfonylpiperidine-2-carboxamide
CFAMM00255205 CHEMBL2425941 Bioactive (2R)-2-[cyanomethyl-[4-(2-fluoroethoxy)phenyl]sulfonylamino]-N-hydroxy-3-methylbutanamide
CFAMM00255269 CHEMBL206688 Bioactive (3S)-4-(4-but-3-ynoxyphenyl)sulfonyl-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
CFAMM00254966 CHEMBL94248 Bioactive AGN-PC-037KLC
CFAMM00255282 CHEMBL104022 Bioactive AGN-PC-073P4Q
CFAMM00254932 CHEMBL370129 Bioactive 4-(4-but-2-ynoxyphenyl)sulfonyl-N-hydroxythiomorpholine-3-carboxamide
CFAMM00255156 CHEMBL123967 Bioactive N-hydroxy-1-(4-methoxyphenyl)sulfonyl-4-methylsulfonylpiperazine-2-carboxamide
CFAMM00254958 CHEMBL140569 Bioactive (3S)-N-hydroxy-2,2-dimethyl-4-(4-phenoxyphenyl)sulfonyl-1,4-thiazepane-3-carboxamide
CFAMM00255335 CHEMBL441662 Bioactive (3S)-N-hydroxy-4-(4-methoxyphenyl)sulfonyl-2,2-dimethyl-1,4-thiazonane-3-carboxamide
CFAMM00255048 CHEMBL231879 Bioactive 4-[(4-but-2-ynoxyphenyl)sulfonylmethyl]-N-hydroxy-1-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]sulfonylpiperidine-4-carboxamide
CFAMM00255074 CHEMBL392505 Bioactive 4-[(4-but-2-ynoxyphenyl)sulfonylmethyl]-1-cyclopropylsulfonyl-N-hydroxypiperidine-4-carboxamide
CFAMM00255162 CHEMBL436324 Bioactive 1-(4-but-2-ynoxyphenyl)sulfonyl-N-hydroxypiperazine-2-carboxamide
CFAMM00255413 CHEMBL342210 Bioactive (3S)-N-hydroxy-4-(4-methoxyphenyl)sulfonyl-2,2-dimethyl-1,1-dioxo-1,4-thiazepane-3-carboxamide
CFAMM00254978 CHEMBL181328 Bioactive AGN-PC-075CRW
CFAMM00255341 CHEMBL140970 Bioactive (3S)-N-hydroxy-4-(4-methoxyphenyl)sulfonyl-2,2-dimethyl-1,4-thiazepane-3-carboxamide
CFAMM00255219 CHEMBL141080 Bioactive (3S)-N-hydroxy-4-(4-methoxyphenyl)sulfonyl-2,2-dimethylthiomorpholine-3-carboxamide
CFAMM00255393 CHEMBL231667 Bioactive AGN-PC-0768KN
CFAMM00255267 CHEMBL104599 Bioactive 4-benzylsulfanyl-N-hydroxy-2-[2-methylpropyl-(4-phenoxyphenyl)sulfonylamino]butanamide
CFAMM00255340 CHEMBL104722 Bioactive AGN-PC-073PFR
CFAMM00255039 CHEMBL380343 Bioactive tert-butyl N-[5-[4-[(3S)-3-(hydroxycarbamoyl)-2,2-dimethylthiomorpholin-4-yl]sulfonylphenoxy]pent-3-ynyl]carbamate
CFAMM00255053 CHEMBL194237 Bioactive 1-(4-but-2-ynoxyphenyl)sulfonyl-N-hydroxy-4-methylsulfonylpiperazine-2-carboxamide
CFAMM00255412 CHEMBL181317 Bioactive AGN-PC-075CUR
CFAMM00255332 DNC006333 Investigative Drug TMI-05

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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