CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1950
Family Name Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic-d-phe-arg-2-nal-nhch3 Family
No. of Seeds 11 No. of Other Members 31
Family Centroid CFAMM00255435 Functional Category Investigative Drug
Superfamily Melanocortin receptor 4 and Major prion protein Binder Superfamily
Class Class 1354

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
DNA Binder Procarbazine Family 8 358
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Poly [ADP-ribose] polymerase 1 Inhibitor KU-0059436 Family 21 45
Motilin receptor Ligand GSK962040 Family 30 457
Substance-P receptor Ligand Orvepitant Family 11 46
Neuropeptide Y receptor type 1 Ligand BIBO3304 Family 4 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Major prion protein Inhibitor Anti-prp Antibodies Family 1 6
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Prothrombin Inhibitor Efegatran Family 9 47
Neutrophil elastase Inhibitor FK-706 Family 8 85
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Prothrombin Inhibitor LB30812 Family 12 36
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Prothrombin Inhibitor Ppack Family 5 4
Prothrombin Inhibitor D-leucyl-n-(4-carbamimidoylbenzyl)-l-pro... 13 44
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 2 2
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
Cathepsin G and Chymase Inhibitor JNJ-10311795 Family 1 3
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 18
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Substance-P receptor ligand (2S)-N-[(2S)-1-[benzyl(methyl)amin... 5 9
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Plasminogen and Plasma kallikrein inhibitor CHEMBL2016864 family 9 16
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-2-anil... 1 2
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Growth hormone secretagogue receptor type 1 ligand (E)-5-amino... 2 2
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 8
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Substance-P receptor ligand AGN-PC-075NRR family 2 1
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Neprilysin inhibitor SureCN489232 family 3 9
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Growth factor receptor-bound protein 2 ligand [4-[[(2S,5S,9S,1... 2 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Lysine-specific histone demethylase 1A and Amine oxidase [flav... 2 1
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 7 3
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Somatostatin receptor type 1 and Somatostatin receptor type 4 ... 2 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 7 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Substance-P receptor ligand AGN-PC-073QYE family 6 11
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 13 3
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Sodium-dependent dopamine transporter and Transporter inhibito... 6 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
Coagulation factor X inhibitor ethyl 2-[[(3S)-3-[[2-[[(2R)-2-(... 4 0
Prolyl endopeptidase inhibitor [(2S)-2-(pyrrolidine-1-carbonyl... 3 0
Collagenase 3 and Interstitial collagenase inhibitor (4-benzyl... 2 0
Gonadotropin-releasing hormone receptor ligand CHEMBL410779 fa... 3 0
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 1 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Histamine H3 receptor ligand Conessine analogue, 13e family 1 0
Legumain-like protease inhibitor N-[(2R)-1-[[(2S)-1-[2-(2-amin... 6 7
Prothrombin inhibitor 1-(2-amino-3,3-diphenylpropanoyl)-N-[(3-... 1 1
Cathepsin L1 inhibitor (2R)-2-[[3-benzylsulfanyl-2-[[2-(4-phen... 1 0
Substance-P receptor ligand AGN-PC-074VYH family 4 0
Coagulation factor X and Coagulation factor VII inhibitor AGN-... 1 2
DNA polymerase beta and Muscleblind-like protein 1 inhibitor C... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00255443 CHEMBL215895 Bioactive N-[(2R)-1-[(2S)-2-[3-(diaminomethylideneamino)propyl]-4-[(2S)-1-(methylamino)-3-naphthalen-2-yl-1-oxopropan-2-yl]-3-oxopiperazin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
CFAMM00255436 CHEMBL214410 Bioactive (2S)-2-[(3S)-3-[3-(diaminomethylideneamino)propyl]-4-[(2R)-3-(4-fluorophenyl)-2-piperazin-1-ylpropanoyl]-2-oxopiperazin-1-yl]-N-methyl-3-naphthalen-2-ylpropanamide
CFAMM00255428 CHEMBL215833 Bioactive (2S)-2-acetamido-N-[(2R)-1-[(2S)-2-[3-(diaminomethylideneamino)propyl]-4-[(2S)-1-(methylamino)-3-naphthalen-2-yl-1-oxopropan-2-yl]-3-oxopiperazin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]pentanediamide
CFAMM00255420 CHEMBL378837 Bioactive (2S)-2-[(3S)-4-[(2R)-2-amino-3-(4-fluorophenyl)propanoyl]-3-[3-(diaminomethylideneamino)propyl]-2-oxopiperazin-1-yl]-N-methyl-3-naphthalen-2-ylpropanamide
CFAMM00255440 CHEMBL322912 Bioactive SureCN14527598
CFAMM00255445 CHEMBL384176 Bioactive (2S)-2-[(3S)-4-[(2R)-2-acetamido-3-(4-fluorophenyl)propanoyl]-3-[3-(diaminomethylideneamino)propyl]-2-oxopiperazin-1-yl]-N-methyl-3-naphthalen-2-ylpropanamide
CFAMM00255423 CHEMBL215576 Bioactive (2S)-2-[(3S)-3-[3-(diaminomethylideneamino)propyl]-4-[3-(4-fluorophenyl)propanoyl]-2-oxopiperazin-1-yl]-N-methyl-3-naphthalen-2-ylpropanamide
CFAMM00255437 CHEMBL1162065 Bioactive N-[(2R)-1-[[(2R)-1-[[(1S)-2-amino-2-oxo-1-phenylethyl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]piperidine-4-carboxamide
CFAMM00255435 DNC006335 Investigative Drug Tic-D-Phe-Arg-2-Nal-NHCH3

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27255 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543