CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1953
Family Name Mitogen-activated protein kinase 14 and Tyrosine-protein kinase Lck Inhibitor GW-788388 Family
No. of Seeds 5 No. of Other Members 10
Family Centroid CFAMM00255477 Functional Category Investigative Drug
Superfamily Mitogen-activated protein kinase 14 and Tyrosine-protein kinase Lck Inhibitor GW-788388 Superfamily
Class Class 2305

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Hepatocyte growth factor receptor Ligand MK-8033 Family 19 42
Coagulation factor X Inhibitor Otamixaban Family 9 21
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 6
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 1 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Casein kinase I isoform delta and Casein kinase I isoform epsi... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
TGF-beta receptor type-1 ligand Methyl 4-(4-(3-(pyridin-2-yl)-... 1 2
TGF-beta receptor type-1 ligand SureCN373106 family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00255481 CHEMBL403539 Bioactive pyrazolopyridine, 47
CFAMM00255487 CHEMBL429674 Bioactive pyrazolopyridine, 46
CFAMM00255472 CHEMBL402393 Bioactive pyrazolopyridine, 49
CFAMM00255485 CHEMBL270817 Bioactive pyrazolopyridine, 48
CFAMM00255477 DNC006358 Investigative Drug GW-788388

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26231 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543