CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1962
Family Name Cholecystokinin receptor type A Ligand VL-1499 Family
No. of Seeds 12 No. of Other Members 133
Family Centroid CFAMM00255749 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Cholecystokinin receptor type A Ligand VL-1499 Superfamily
Class Class 311

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Retinoic acid receptor alpha Ligand Tamibarotene Family 5 95
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Prostaglandin G/H synthase 2 Inhibitor Mefenamic Acid Family 7 137
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Thymidylate synthase Inhibitor Leucovorin/5-fluorouracil Family 9 83
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Integrin alpha-4 Inhibitor R1295 Family 18 59
Cholecystokinin receptor type A Ligand Gi 181771 Family 3 18
Glycine receptor subunit beta Ligand Gw 468816 Family 4 67
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Integrin beta-1 Inhibitor R411 Family 33 44
Dopamine reuptake Inhibitor Amineptine Family 2 5
Motilin receptor Ligand GSK962040 Family 30 457
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Dihydroorotase, putative Inhibitor 5-amino Orotate Family 2 4
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Cyclophilin receptor and Cyclosporine receptor Ligand D-43787 ... 2 13
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Trifunctional purine biosynthetic protein adenosine-3 Inhibito... 2 1
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor L-709780 Family 9 10
Integrin beta-3 Inhibitor L-767679 Family 3 6
Integrin beta-3 Inhibitor L-750034 Family 7 38
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Integrin beta-3 Inhibitor Lotrafiban Family 5 1
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Protein kinase C eta type and Protein kinase C delta type Inhi... 9 12
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Beta-secretase 1 Inhibitor KMI-538 Family 4 20
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Beta-secretase 1 Inhibitor GSK-188909 Family 16 11
Leukotriene A-4 hydrolase Inhibitor N5-[4-(n-phenylamino)pheny... 2 3
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Leukotriene A-4 hydrolase Inhibitor SA-6541 Family 4 32
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 18
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 5
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
D(4) dopamine receptor and D(2) dopamine receptor ligand methy... 2 11
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 3 3
Angiotensin-converting enzyme inhibitor AGN-PC-074KD3 family 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Angiotensin-converting enzyme inhibitor (2R)-1-[4-carboxy-4-(p... 3 3
Integrin beta-3 and Integrin alpha-IIb inhibitor 2-[7-[[4-(N'-... 7 15
Beta-secretase 1 and Cathepsin D inhibitor 3-(4-chloro-N-methy... 1 0
Protein kinase C alpha type inhibitor 5-[3,5-bis(trifluorometh... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Angiotensin-converting enzyme inhibitor (2S)-1-[(2S)-2-sulfany... 7 23
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 2 0
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7345980... 4 6
Pol polyprotein inhibitor Lysine Sulfonamide 11o family 2 6
Protein kinase C delta type and Protein kinase C alpha type in... 5 0
Mitogen-activated protein kinase 1 and M17 leucyl aminopeptida... 1 21
Pol polyprotein inhibitor 183860-48-2 family 5 1
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7285564... 1 2
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Dipeptidyl peptidase 4 inhibitor SureCN1499864 family 4 7
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
Prostaglandin E2 receptor EP4 subtype ligand SureCN3567929 family 10 3
Prostaglandin E2 receptor EP4 subtype ligand SureCN3581203 family 1 0
Prostaglandin E2 receptor EP4 subtype ligand SureCN3573573 family 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor (E)-3-[4-[(2,6-... 3 1
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Free fatty acid receptor 1 ligand AGN-PC-03ZC6J family 2 14
Chymase and Chymotrypsin-C inhibitor 3-[[2,2-difluoro-4-[[(2S)... 6 10
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 7 3
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Pol polyprotein inhibitor 3-[(4R,5R,6R)-4-benzyl-3-(3-carbamoy... 3 1
Ectonucleotide pyrophosphatase/phosphodiesterase family member... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[1-[2-[4-[(2... 2 8
Kappa-type opioid receptor ligand 4-[3-[(1S)-1-[methyl-[2-[4-(... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6823871 f... 9 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Sphingosine 1-phosphate receptor 1 ligand 7-(2-hydroxyethyl)-1... 2 10
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-... 3 3
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Angiotensin-converting enzyme inhibitor (2S)-2-[[(3R)-5-(carbo... 6 4
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
Cathepsin D and Cathepsin E inhibitor methyl (2S)-1-[(2R)-2-[[... 1 0
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
Angiotensin-converting enzyme inhibitor 1-[(2R,4R)-4-carboxy-2... 2 3
Prostaglandin E synthase inhibitor 4-chloro-2-[[1,3-dioxo-2-(1... 1 0
Caspase-9 and Caspase-8 inhibitor 4-fluoro-2-[[2-[[(2S)-3-meth... 1 11
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[1-[2-(... 12 2
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
Pol polyprotein inhibitor 2,5-bis[(2-{[(benzyloxy)carbonyl]ami... 2 3
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-037CNR f... 5 8
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Angiotensin-converting enzyme inhibitor 2-(N-[(2S)-6-amino-2-[... 2 1
Atrial natriuretic peptide receptor 1 and Atrial natriuretic p... 3 0
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
Dihydrofolate reductase inhibitor AGN-PC-073POJ family 1 0
Granzyme B and Caspase-3 inhibitor CHEMBL304368 family 2 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(4-brom... 2 0
Caspase-8 and Caspase-3 inhibitor (3S)-3-[[(2S)-4-methyl-2-[[2... 3 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 1 0
Angiotensin-converting enzyme inhibitor 89177-63-9 family 2 0
Protease and Replicase polyprotein 1a inhibitor AC1LALLS family 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[4-[2-[... 1 0
Glycogen phosphorylase, liver form inhibitor SureCN5195475 family 9 5
Pol polyprotein inhibitor 3-amino-N-[(2S,3S,4R,5S)-5-[(3-amino... 2 1
Glycogen phosphorylase, liver form inhibitor SureCN5419308 family 3 0
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Glycogen phosphorylase, liver form inhibitor AGN-PC-00CDLB family 2 0
Neprilysin and Angiotensin-converting enzyme inhibitor 3-[(3S)... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-009EMK... 2 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Glucagon receptor and Adenylate cyclase type 1 ligand AGN-PC-0... 1 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 4 6
Tyrosine-protein kinase ITK/TSK and Mast/stem cell growth fact... 1 0
E3 ubiquitin-protein ligase Mdm2 inhibitor methyl 2-(4-chlorop... 2 8
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-... 2 11
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 12
NP Methyl 2-(5,11-dioxo-2,3,11,11a-tetrahydro-1h-benzo[e]pyrro... 2 1
4-oxo-2-[(2-oxo1H-quinoline-4-carbonyl)amino]butanoic NP (s)-m... 1 3
NP (s)-methyl 2-(3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1... 11 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00255777 CHEMBL472140 Bioactive SureCN5195128
CFAMM00255864 CHEMBL516081 Bioactive SureCN5195805
CFAMM00255870 CHEMBL159261 Bioactive (2S)-2-[(1-benzyl-5-oxopyrrolidine-2-carbonyl)amino]-3-[4-[(5-methyl-2-nitrobenzoyl)amino]phenyl]propanoic acid
CFAMM00255733 CHEMBL128382 Bioactive (2S)-2-[[(2S)-1-benzyl-5-oxopyrrolidine-2-carbonyl]amino]-3-[4-(3-oxo-1H-isoindol-2-yl)phenyl]propanoic acid
CFAMM00255863 CHEMBL85503 Bioactive (2S)-3-[4-[(2,6-dichlorobenzoyl)amino]phenyl]-2-[[2-(methylamino)benzoyl]amino]propanoic acid
CFAMM00255775 CHEMBL28244 Bioactive (2S)-3-[4-[(2-acetylphenyl)carbamoyl]phenyl]-2-[[(2S)-1-benzyl-5-oxopyrrolidine-2-carbonyl]amino]propanoic acid
CFAMM00255796 CHEMBL2093973 Bioactive (2S)-2-[[(3S)-1-(carboxymethyl)-2-oxo-3,4,5,6-tetrahydro-1-benzazocin-3-yl]amino]-4-phenylbutanoic acid;hydrochloride
CFAMM00255813 CHEMBL350811 Bioactive SureCN5164153
CFAMM00255728 CHEMBL347875 Bioactive (2S)-2-[(1-benzyl-5-oxopyrrolidine-2-carbonyl)amino]-3-[4-[(2-nitrobenzoyl)amino]phenyl]propanoic acid
CFAMM00255795 CHEMBL163216 Bioactive (2S)-2-[(1-benzyl-5-oxopyrrolidine-2-carbonyl)amino]-3-[4-[(2,4,5-trifluorobenzoyl)amino]phenyl]propanoic acid
CFAMM00255750 DNC006386 Investigative Drug VL-0699
CFAMM00255749 DNC006385 Investigative Drug VL-1499

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

42929 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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