CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1976
Family Name 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Ligand 3-{[2-(2-phenylethyl)phenoxy]methyl}pyridine Family
No. of Seeds 4 No. of Other Members 35
Family Centroid CFAMM00256135 Functional Category Investigative Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Ligand Sarizotan Superfamily
Class Class 1129

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Citric Acid family 2 58
Multidrug resistance protein 3 Inhibitor LY335979 Family 1 3
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
SB1518 family 7 103
Apricoxib family 8 77
PF-02545920 family 16 140
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Squalene synthase Inhibitor ER-119884 Family 2 3
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 3 24
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(4-f... 2 5
Renin Inhibitor CP-305202 Family 9 30
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... 5 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 1 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Histamine H1 receptor and Potassium voltage-gated channel subf... 3 1
Leukotriene B4 receptor 1 ligand AGN-PC-04XM3V family 3 10
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 1
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Endothelin-1 receptor ligand SureCN8118632 family 4 5
Somatostatin receptor type 2 ligand SureCN4317006 family 10 1
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Retinoic acid receptor RXR-alpha ligand 6-[(3-butoxy-5,5,8,8-t... 2 2
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Prostaglandin D2 receptor 2 ligand 2-[4-chloro-2-[2-(4-propylp... 2 13
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... 2 3
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Metabotropic glutamate receptor 5 ligand 2-chloro-6-[(2-methyl... 1 4
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Beta-secretase 1 inhibitor CHEMBL2152919 family 1 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Acetylcholinesterase and Cholinesterase inhibitor 6-bromo-3-[(... 2 0
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 7
Sodium-dependent serotonin transporter and Histamine H3 recept... 6 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Transient receptor potential cation channel subfamily V member... 6 1
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 8
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
Renin inhibitor SureCN6043852 family 2 0
Renin inhibitor SureCN6042213 family 2 3
Renin inhibitor SureCN6044003 family 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor N-[4... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Sodium-dependent serotonin transporter inhibitor SureCN5878703... 4 5
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 7 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 2
Metabotropic glutamate receptor 2 ligand SureCN6733905 family 11 8
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Reverse transcriptase/RNaseH inhibitor 3-[4-cyclopropyl-1,1,1-... 1 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3
Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-pr... 6 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
P2X purinoceptor 7 inhibitor 3-[1-[4-(3-nitrophenyl)phenoxy]-4... 1 1
Coagulation factor X and Cationic trypsin inhibitor 1qb6 family 4 15
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-073... 1 1
Cytochrome P450 2D6 inhibitor AGN-PC-0509UI family 1 2
Muscleblind-like protein 1 and Lysosomal alpha-glucosidase inh... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-075NG1... 1 0
Beta-lactamase and Muscleblind-like protein 1 inhibitor 2,3-Bi... 1 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Fatty-acid amide hydrolase 1 inhibitor [3-[(2-chloropyridin-3-... 3 0
Acetylcholinesterase inhibitor 7-[5-(3,5-difluoro-4-methoxypyr... 1 0
Enoyl-acyl-carrier protein reductase inhibitor Triclosan deriv... 3 0
Pol polyprotein inhibitor tert-butyl N-[(2S,3R)-3-hydroxy-4-[[... 1 1
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
4-methyl-7-(pyridin-3-ylmethylideneamino)chromen-2-one NP (e)-... 1 0
7-(4-hydroxy-2-oxo-2H-chromen-3-yl)chromeno[4',3':3,4]cyclopen... 2 0
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0
dimethyl-4-[[4-(2-pyridin-4-ylethyl)piperazin-4-ium-1-yl]methy... 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00256150 DNC010112 Investigative Drug 4-[2-(4-Benzylphenoxy)ethyl]pyridine
CFAMM00256143 DNC006423 Investigative Drug 3-(3-(3-chlorobenzyloxy)-5-methylphenyl)pyridine
CFAMM00256135 DNC006912 Investigative Drug 3-{[2-(2-phenylethyl)phenoxy]methyl}pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26400 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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