| Cousin Family Names | Seeds | Members |
|---|
| Beta adrenergic receptor ligand monosubstituted indole derivat... | 14 | 475 |
| DNA Binder Primaquine Family | 3 | 245 |
| Acetylcholinesterase Inhibitor Pyridostigmine Family | 5 | 197 |
| Histamine H1 receptor Ligand Doxylamine Family | 2 | 91 |
| cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... | 53 | 741 |
| Histamine H1 receptor Ligand Mepyramine Family | 5 | 65 |
| Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family | 8 | 20 |
| Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family | 8 | 265 |
| Citric Acid family | 2 | 58 |
| Multidrug resistance protein 3 Inhibitor LY335979 Family | 1 | 3 |
| Cannabinoid receptor 1 Ligand Taranabant Family | 20 | 30 |
| Calcium-activated potassium channel subunit alpha-1 Ligand AVE... | 3 | 284 |
| Nicotinic acetylcholine receptor Ligand AZD0328 Family | 11 | 97 |
| Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... | 49 | 172 |
| Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... | 5 | 74 |
| 5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... | 9 | 115 |
| SB1518 family | 7 | 103 |
| Apricoxib family | 8 | 77 |
| PF-02545920 family | 16 | 140 |
| Nicotinic acetylcholine receptor Ligand Dianicline Family | 6 | 13 |
| Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... | 21 | 194 |
| Reverse transcriptase Inhibitor 3'thiacytidine Family | 4 | 29 |
| 5-hydroxytryptamine receptor 1B Ligand GR55562 Family | 3 | 45 |
| Dihydroorotate dehydrogenase Inhibitor LY214352 Family | 2 | 17 |
| 5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family | 2 | 86 |
| Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... | 4 | 37 |
| Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... | 5 | 48 |
| Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... | 3 | 12 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... | 5 | 23 |
| Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... | 5 | 34 |
| Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... | 3 | 30 |
| Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family | 30 | 170 |
| Platelet-derived growth factor receptor alpha and Platelet-der... | 2 | 9 |
| Platelet-derived growth factor receptor beta and Epidermal gro... | 3 | 7 |
| Platelet-derived growth factor receptor alpha and Platelet-der... | 2 | 14 |
| 5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... | 2 | 10 |
| Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... | 11 | 48 |
| Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... | 12 | 3 |
| Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... | 9 | 49 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... | 13 | 26 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... | 7 | 6 |
| Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... | 2 | 5 |
| D(2) dopamine receptor Ligand SLV-314 Family | 19 | 69 |
| Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... | 3 | 12 |
| Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... | 3 | 34 |
| Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... | 7 | 2 |
| RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... | 67 | 59 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... | 14 | 214 |
| RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... | 3 | 7 |
| Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... | 3 | 9 |
| Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... | 3 | 27 |
| Delta-type opioid receptor and Mu-type opioid receptor Ligand ... | 8 | 57 |
| Squalene synthase Inhibitor ER-119884 Family | 2 | 3 |
| Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... | 7 | 4 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... | 4 | 5 |
| MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family | 2 | 506 |
| Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... | 2 | 14 |
| 5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... | 4 | 32 |
| 5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... | 3 | 24 |
| Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... | 10 | 5 |
| Potassium voltage-gated channel subfamily A member 5 Ligand 2-... | 5 | 69 |
| DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... | 4 | 13 |
| Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(4-f... | 2 | 5 |
| Renin Inhibitor CP-305202 Family | 9 | 30 |
| Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family | 3 | 41 |
| Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... | 18 | 17 |
| Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... | 7 | 27 |
| Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... | 4 | 20 |
| Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... | 2 | 7 |
| Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... | 8 | 46 |
| Acetylcholinesterase Inhibitor Lysicamine Family | 2 | 8 |
| Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... | 4 | 5 |
| Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... | 22 | 57 |
| Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... | 5 | 2 |
| Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... | 1 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 7 | 1 |
| Histamine H1 receptor and Potassium voltage-gated channel subf... | 3 | 1 |
| Leukotriene B4 receptor 1 ligand AGN-PC-04XM3V family | 3 | 10 |
| Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... | 2 | 18 |
| 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... | 2 | 0 |
| Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... | 6 | 4 |
| Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... | 1 | 0 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... | 3 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... | 2 | 5 |
| Sodium channel protein type 10 subunit alpha and Sodium channe... | 3 | 22 |
| Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... | 8 | 8 |
| Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... | 1 | 15 |
| Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... | 4 | 23 |
| D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... | 1 | 1 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... | 3 | 3 |
| DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... | 1 | 6 |
| Glucagon receptor and Mitogen-activated protein kinase 14 liga... | 6 | 5 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 8 | 8 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 11 | 4 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 3 | 7 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 2 | 4 |
| Potassium voltage-gated channel subfamily H member 2 and Sodiu... | 2 | 13 |
| Prostaglandin D2 receptor 2 ligand SureCN137822 family | 3 | 0 |
| Endothelin-1 receptor ligand SureCN8118632 family | 4 | 5 |
| Somatostatin receptor type 2 ligand SureCN4317006 family | 10 | 1 |
| Somatostatin receptor type 2 ligand SureCN4313450 family | 2 | 25 |
| Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... | 8 | 27 |
| 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 16 | 19 |
| Retinoic acid receptor RXR-alpha ligand 6-[(3-butoxy-5,5,8,8-t... | 2 | 2 |
| Sodium-dependent serotonin transporter inhibitor SureCN7536104... | 6 | 2 |
| Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... | 3 | 2 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 3 | 0 |
| Prostaglandin D2 receptor 2 ligand 2-[4-chloro-2-[2-(4-propylp... | 2 | 13 |
| Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... | 4 | 9 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 2 | 1 |
| Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... | 2 | 3 |
| Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... | 6 | 1 |
| Metabotropic glutamate receptor 5 ligand 2-chloro-6-[(2-methyl... | 1 | 4 |
| Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... | 8 | 15 |
| Beta-secretase 1 inhibitor CHEMBL2152919 family | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... | 5 | 0 |
| 5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... | 5 | 14 |
| Potassium voltage-gated channel subfamily H member 2 and 5-hyd... | 2 | 2 |
| 5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... | 6 | 4 |
| 5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... | 4 | 4 |
| Acetylcholinesterase and Cholinesterase inhibitor 6-bromo-3-[(... | 2 | 0 |
| Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... | 1 | 0 |
| P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... | 4 | 14 |
| Sodium-dependent noradrenaline transporter and Sodium-dependen... | 2 | 7 |
| Sodium-dependent serotonin transporter and Histamine H3 recept... | 6 | 4 |
| Peroxisome proliferator-activated receptor delta and Peroxisom... | 2 | 2 |
| Histamine H3 receptor and Sodium-dependent serotonin transport... | 3 | 2 |
| Potassium voltage-gated channel subfamily KQT member 2 ligand ... | 3 | 4 |
| Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... | 1 | 8 |
| Histamine H3 receptor and Sodium-dependent serotonin transport... | 2 | 0 |
| Transient receptor potential cation channel subfamily V member... | 6 | 1 |
| Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... | 5 | 15 |
| Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... | 4 | 4 |
| Sodium-dependent serotonin transporter and Sodium-dependent no... | 2 | 4 |
| Sodium-dependent serotonin transporter and Sodium-dependent no... | 3 | 8 |
| Sodium-dependent serotonin transporter and Sodium-dependent no... | 2 | 0 |
| C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... | 3 | 5 |
| Renin inhibitor SureCN6043852 family | 2 | 0 |
| Renin inhibitor SureCN6042213 family | 2 | 3 |
| Renin inhibitor SureCN6044003 family | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor N-[4... | 1 | 0 |
| Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... | 2 | 0 |
| cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... | 2 | 0 |
| 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 23 | 5 |
| Glucocorticoid receptor ligand SureCN3894124 family | 3 | 0 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 2 | 2 |
| Sodium-dependent serotonin transporter inhibitor SureCN5878703... | 4 | 5 |
| Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... | 1 | 0 |
| D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... | 1 | 0 |
| Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... | 2 | 1 |
| Lanosterol synthase inhibitor AGN-PC-07BZTX family | 2 | 0 |
| Sodium-dependent noradrenaline transporter and Sodium-dependen... | 1 | 0 |
| Melanin-concentrating hormone receptor 1 and Potassium voltage... | 7 | 1 |
| D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... | 3 | 2 |
| Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... | 2 | 0 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 6 | 0 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... | 1 | 2 |
| Metabotropic glutamate receptor 2 ligand SureCN6733905 family | 11 | 8 |
| Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... | 2 | 0 |
| Reverse transcriptase/RNaseH inhibitor 3-[4-cyclopropyl-1,1,1-... | 1 | 0 |
| Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... | 1 | 0 |
| Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... | 2 | 3 |
| Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-pr... | 6 | 0 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... | 2 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 3 | 3 |
| P2X purinoceptor 7 inhibitor 3-[1-[4-(3-nitrophenyl)phenoxy]-4... | 1 | 1 |
| Coagulation factor X and Cationic trypsin inhibitor 1qb6 family | 4 | 15 |
| Coagulation factor X and Cationic trypsin inhibitor AGN-PC-073... | 1 | 1 |
| Cytochrome P450 2D6 inhibitor AGN-PC-0509UI family | 1 | 2 |
| Muscleblind-like protein 1 and Lysosomal alpha-glucosidase inh... | 2 | 0 |
| Sigma non-opioid intracellular receptor 1 ligand AGN-PC-075NG1... | 1 | 0 |
| Beta-lactamase and Muscleblind-like protein 1 inhibitor 2,3-Bi... | 1 | 2 |
| Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... | 1 | 2 |
| Fatty-acid amide hydrolase 1 inhibitor [3-[(2-chloropyridin-3-... | 3 | 0 |
| Acetylcholinesterase inhibitor 7-[5-(3,5-difluoro-4-methoxypyr... | 1 | 0 |
| Enoyl-acyl-carrier protein reductase inhibitor Triclosan deriv... | 3 | 0 |
| Pol polyprotein inhibitor tert-butyl N-[(2S,3R)-3-hydroxy-4-[[... | 1 | 1 |
| 3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... | 1 | 1 |
| 4-methyl-7-(pyridin-3-ylmethylideneamino)chromen-2-one NP (e)-... | 1 | 0 |
| 7-(4-hydroxy-2-oxo-2H-chromen-3-yl)chromeno[4',3':3,4]cyclopen... | 2 | 0 |
| (4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... | 1 | 0 |
| dimethyl-4-[[4-(2-pyridin-4-ylethyl)piperazin-4-ium-1-yl]methy... | 7 | 0 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
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How to cite our database |
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C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
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