CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID198
Family Name Kappa-type opioid receptor Ligand Brl 52974 Family
No. of Seeds 2 No. of Other Members 27
Family Centroid CFAMM00183930 Functional Category Investigative Drug with Natural Product
Superfamily Melanocortin receptor and Kappa-type opioid receptor Binder Superfamily
Class Class 1016

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arof... 3 196
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 5 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN9931311 family 2 0
P2X purinoceptor 7 inhibitor SureCN108747 family 5 6
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
P2X purinoceptor 7 inhibitor AGN-PC-087WY0 family 1 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
5-hydroxytryptamine receptor 2B ligand SureCN1299437 family 6 7
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Coagulation factor X and Prothrombin inhibitor SureCN6593603 f... 3 0
C-C chemokine receptor type 5 ligand N-[3-[4-[3-cyclohexyl-5-(... 5 4
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Substance-K receptor ligand SureCN9035669 family 10 5
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Tripeptidyl-peptidase 2 inhibitor (2S)-2-amino-1-[(2S)-5-chlor... 1 0
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Histamine H3 receptor ligand SureCN3534043 family 3 3
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(3,4-dichlor... 2 1
Histamine H3 receptor ligand [3-methyl-2-[(1-propan-2-ylpiperi... 5 3
Histamine H3 receptor ligand SureCN1382602 family 6 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1
Substance-K receptor ligand AGN-PC-074GCM family 2 2
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-fluorop... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00183939 CHEMBL200519 Bioactive AGN-PC-075YUH
CFAMM00183930 DNC000351 Investigative Drug BRL 52974

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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