| Cousin Family Names | Seeds | Members |
|---|
| 5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... | 14 | 498 |
| D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... | 12 | 720 |
| 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... | 4 | 171 |
| CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Amrino... | 3 | 55 |
| Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... | 7 | 189 |
| Nicotinic acetylcholine receptor Ligand Nicotine Family | 14 | 686 |
| D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... | 22 | 170 |
| Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... | 3 | 54 |
| Histamine H1 receptor ligand tricyclic antidepressant Deslorat... | 6 | 136 |
| Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family | 3 | 73 |
| Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family | 9 | 243 |
| Thromboxane A2 receptor Ligand Ridogrel Family | 7 | 83 |
| Sodium channel protein type 5 subunit alpha Ligand Disopyramid... | 4 | 352 |
| Acetylcholinesterase Inhibitor Tacrine Family | 12 | 515 |
| Farnesyl pyrophosphate synthase Inhibitor Risedronate Family | 4 | 28 |
| D(2) dopamine receptor Ligand Sertindole Family | 3 | 173 |
| Histamine H1 receptor Ligand Pheniramine Family | 10 | 380 |
| Histamine H1 receptor Ligand Triprolidine Family | 19 | 316 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... | 5 | 68 |
| 26S proteasome Inhibitor Bortezomib Family | 7 | 65 |
| SUR2-type K(ATP) channel Ligand Nicorandil Family | 5 | 85 |
| Prothrombin Inhibitor Ximelegatran Family | 8 | 157 |
| G protein-activated inward rectifier potassium channel 4 Ligan... | 3 | 48 |
| Transient receptor potential cation channel subfamily V member... | 15 | 158 |
| Vascular endothelial growth factor Inhibitor PTC299 Family | 6 | 145 |
| Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family | 5 | 154 |
| Potassium voltage-gated channel subfamily KQT member 1 Ligand ... | 13 | 242 |
| Reverse transcriptase Inhibitor Dapivirine Family | 5 | 72 |
| Gamma-aminobutyric acid receptor Ligand E-2007 Family | 7 | 118 |
| D(1B) dopamine receptor Ligand LE-300 Family | 65 | 452 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... | 14 | 234 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 23 | 63 |
| Amg 423 family | 7 | 47 |
| ABC294640 family | 5 | 75 |
| C-C chemokine receptor type 3 Ligand YM-344031 Family | 19 | 106 |
| 5-hydroxytryptamine receptor 2A Ligand RP-68303 Family | 7 | 44 |
| Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family | 11 | 42 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... | 4 | 34 |
| Nicotinic acetylcholine receptor Ligand Epibatidine Family | 36 | 19 |
| 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... | 6 | 17 |
| Ribonucleoside-diphosphate reductase large subunit Inhibitor T... | 1 | 1 |
| Carbonic anhydrase 2 Inhibitor Cyanamide Family | 2 | 32 |
| Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... | 10 | 43 |
| Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... | 31 | 66 |
| D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... | 3 | 15 |
| D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... | 6 | 48 |
| Aromatase Inhibitor Rogletimide Family | 1 | 2 |
| Histone deacetylase 1 and Histone deacetylase 2 Inhibitor Cycl... | 1 | 0 |
| Epidermal growth factor receptor Ligand PD-158780 Family | 98 | 89 |
| D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... | 7 | 102 |
| Potassium voltage-gated channel subfamily H member 2 Ligand 5-... | 5 | 14 |
| 5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... | 5 | 4 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... | 4 | 19 |
| Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... | 4 | 9 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... | 9 | 40 |
| Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... | 3 | 5 |
| Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... | 4 | 21 |
| Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... | 2 | 11 |
| Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... | 5 | 27 |
| Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... | 17 | 29 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... | 7 | 16 |
| Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... | 14 | 22 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... | 1 | 6 |
| 5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... | 7 | 79 |
| Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... | 6 | 32 |
| 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... | 3 | 2 |
| Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... | 19 | 64 |
| Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... | 6 | 24 |
| Transient receptor potential cation channel subfamily V member... | 6 | 23 |
| D(4) dopamine receptor Ligand ABT-670 Family | 4 | 14 |
| Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family | 4 | 3 |
| Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... | 11 | 26 |
| Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... | 7 | 7 |
| Transient receptor potential cation channel subfamily V member... | 2 | 26 |
| Farnesyl pyrophosphate synthase Inhibitor Piridronic Acid Family | 3 | 14 |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... | 8 | 25 |
| Nitric oxide synthase, inducible and Nitric oxide synthase, br... | 9 | 24 |
| Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... | 4 | 13 |
| 5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... | 4 | 22 |
| Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... | 4 | 10 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... | 2 | 4 |
| Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... | 2 | 16 |
| Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... | 6 | 14 |
| Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... | 3 | 12 |
| Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... | 2 | 2 |
| Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... | 8 | 38 |
| Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... | 19 | 32 |
| Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(met... | 4 | 15 |
| Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... | 3 | 18 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... | 2 | 4 |
| Cathepsin S Inhibitor 6-(3-(trifluoromethyl)phenyl)picolinonit... | 7 | 2 |
| Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... | 2 | 22 |
| Cathepsin L1 Inhibitor (3-bromobenzoylpyridine)thiosemicarbazo... | 1 | 0 |
| Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... | 94 | 23 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... | 6 | 10 |
| Reverse transcriptase Inhibitor PT-102 Family | 8 | 12 |
| Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... | 8 | 15 |
| 5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... | 10 | 18 |
| Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... | 3 | 2 |
| Reverse transcriptase Inhibitor PT-109 Family | 6 | 7 |
| Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... | 10 | 19 |
| Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... | 12 | 46 |
| Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... | 4 | 6 |
| Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... | 4 | 3 |
| Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... | 4 | 2 |
| Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... | 6 | 10 |
| Fatty-acid amide hydrolase 1 Inhibitor 6-fluoropyridin-3-ylbor... | 1 | 2 |
| Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... | 14 | 22 |
| Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... | 6 | 16 |
| Tyrosinase Inhibitor 5-(pyridin-4-yl)-1,3,4-thiadiazole-2(3h)-... | 1 | 1 |
| Nitric oxide synthase, inducible and Nitric oxide synthase, br... | 1 | 4 |
| Protein kinase C alpha type Inhibitor Dequalinium Analogue Family | 1 | 10 |
| Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... | 62 | 27 |
| Choline kinase alpha Inhibitor Bisquinolinium Derivative Family | 10 | 7 |
| Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... | 1 | 13 |
| Histamine H3 receptor and Potassium voltage-gated channel subf... | 3 | 3 |
| 5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... | 2 | 3 |
| Metabotropic glutamate receptor 5 ligand [18F]FDEGPECO family | 5 | 2 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 4 | 5 |
| Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... | 2 | 5 |
| Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... | 3 | 1 |
| Sodium-dependent serotonin transporter inhibitor SureCN6087152... | 1 | 0 |
| Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... | 1 | 0 |
| Acetylcholine receptor subunit delta ligand Guanidine, N-[(6-c... | 2 | 15 |
| Acetylcholine receptor subunit delta and Neuronal acetylcholin... | 3 | 5 |
| Platelet-activating factor receptor ligand YM-461 family | 1 | 11 |
| Nicotinamide phosphoribosyltransferase and Prelamin-A/C inhibi... | 1 | 0 |
| Prostaglandin E synthase inhibitor AGN-PC-09QHBK family | 3 | 1 |
| Kappa-type opioid receptor and Mu-type opioid receptor ligand ... | 2 | 0 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 1 | 0 |
| Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... | 1 | 1 |
| Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SQ6 family | 3 | 0 |
| Sodium-dependent serotonin transporter and Sodium-dependent no... | 5 | 3 |
| CGMP-dependent protein kinase inhibitor AGN-PC-075XII family | 25 | 7 |
| Metabotropic glutamate receptor 5 ligand AGN-PC-075X3R family | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 3 | 0 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 2 | 0 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 1 | 4 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 5 | 2 |
| D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... | 2 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... | 8 | 0 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 7 | 0 |
| 5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... | 1 | 0 |
| Neuronal acetylcholine receptor subunit alpha-6 ligand AGN-PC-... | 2 | 0 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 3 | 1 |
| Androgen receptor ligand AGN-PC-009ZOP family | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 2 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... | 2 | 1 |
| Platelet-activating factor receptor ligand SureCN9853140 family | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... | 2 | 4 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 2 | 5 |
| 5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... | 1 | 0 |
| D(3) dopamine receptor and D(4) dopamine receptor ligand (7S)-... | 1 | 2 |
| CGMP-dependent protein kinase inhibitor AGN-PC-075INU family | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 10 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... | 1 | 0 |
| Neuropeptide Y receptor type 5 ligand SureCN4464548 family | 17 | 2 |
| Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... | 4 | 2 |
| Thymidylate synthase inhibitor AGN-PC-00EUGY family | 2 | 7 |
| Sodium-dependent noradrenaline transporter and Sodium-dependen... | 5 | 7 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 2 | 3 |
| Nuclear receptor ROR-gamma and Prelamin-A/C ligand 13463-41-7 ... | 1 | 7 |
| Histamine H3 receptor ligand AGN-PC-09M6FC family | 1 | 9 |
| Beta-secretase 2 and Beta-secretase 1 inhibitor 2-cyclopropyl-... | 1 | 1 |
| Acetylcholine-binding protein and Neuronal acetylcholine recep... | 1 | 5 |
| Nonstructural protein 1 and Cruzipain inhibitor CHEMBL1331578 ... | 1 | 2 |
| Tyrosyl-DNA phosphodiesterase 1 and Inositol monophosphatase 1... | 1 | 3 |
| Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... | 1 | 0 |
| Farnesyl pyrophosphate synthase inhibitor [[(5-benzylpyridin-3... | 1 | 0 |
| Potassium voltage-gated channel subfamily A member 5 and Inter... | 2 | 0 |
| Potassium voltage-gated channel subfamily H member 2 ligand 1-... | 1 | 0 |
| Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... | 2 | 1 |
| Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... | 1 | 5 |
| Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... | 1 | 4 |
| Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family | 1 | 0 |
| Nitric oxide synthase, brain inhibitor SureCN1387416 family | 2 | 0 |
| Pyridines and Derivatives Metabolite (S)-Actinidine Family | 1 | 0 |
| Azoles Metabolite 1H-Pyrrolo[2,1-c][1,4]thiazine Family | 1 | 1 |
| NP 3-((1-(3-(2-(pyridin-3-yl)piperidin-1-yl)prop-1-yn-1-yl)cyc... | 12 | 0 |
| methyl-1H-pyrrole NP (z)-2-((3,4-dimethyl-1h-pyrrol-2-yl)methy... | 3 | 0 |
| N-[2-(1-oxidopyridin-1-ium-2-yl)ethyl]-N-phenylacetamide NP 2-... | 1 | 2 |
| Putative NP ZINC38570085 Family | 14 | 0 |
| Putative NP ZINC19701930 Family | 2 | 2 |
| 1,5-dioxidopyrrolo[3,2-c]pyridin-5-ium NP Agn-pc-0639xa Family | 1 | 0 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
|
How to cite our database |
|
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
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