CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1986
Family Name 72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhibitor SR-973 Family
No. of Seeds 9 No. of Other Members 12
Family Centroid CFAMM00256421 Functional Category Investigative Drug with Natural Product
Superfamily 72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhibitor SR-973 Superfamily
Class Class 2316

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Oxytocin receptor Ligand Oxytocin Family 30 182
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
HIV-1 protease Inhibitor Lopinavir Family 4 25
Muscarinic acetylcholine receptor M3 Ligand Darifenacin Family 3 17
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Renin Inhibitor Aliskiren Family 28 107
Zucapsacin family 7 177
Thymopentin family 20 133
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand DA-5018 Family 14 73
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Ceramide glucosyltransferase Inhibitor Eliglustat Tartrate Family 3 2
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Vasopeptidase Inhibitor Fasidotril Family 3 7
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Integrin beta-3 Inhibitor FK-633 Family 2 12
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-tyr(me)-agly-i... 2 1
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 4 42
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Tubulin beta chain Inhibitor 6-ile-ustiloxin Family 4 3
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Aminopeptidase N Inhibitor N1-(3-phenoxybenzyl)-n3-hydroxymalo... 1 5
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Pol polyprotein inhibitor 180968-31-4 family 8 13
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Histamine H3 receptor ligand SureCN4319687 family 8 15
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 1 0
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-carboxyethyl(2-phenoxye... 1 3
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
E3 ubiquitin-protein ligase XIAP inhibitor N-METHYLALANYL-3-ME... 3 14
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
Transient receptor potential cation channel subfamily V member... 3 18
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 2
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 26 12
Neprilysin inhibitor SureCN389939 family 5 6
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Pol polyprotein inhibitor AC1LADQG family 7 1
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 6
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 12
Pol polyprotein inhibitor MDL 74538 family 11 1
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Dipeptidyl peptidase 4 inhibitor 2-cyanopyrrolidine 21e family 6 7
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 191
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Motilin receptor ligand SureCN74051 family 1 0
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 0
Vasopressin V1a receptor and Vasopressin V1b receptor ligand C... 6 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diami... 2 0
Macrophage metalloelastase and Collagenase 3 inhibitor N-hydro... 2 3
Macrophage metalloelastase and Collagenase 3 inhibitor (2S)-N-... 2 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (5Z,8... 4 2
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Renin inhibitor (3S,6R)-6-(cyclohexylmethyl)-7-hydroxy-7-[[(2S... 1 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 2 0
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 5 2
Follicle-stimulating hormone receptor ligand SureCN6140614 family 2 8
Histamine H3 receptor ligand SureCN7244264 family 1 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-4-o... 4 5
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Neutrophil collagenase and Collagenase 3 inhibitor [4-(4-chlor... 2 0
Stromelysin-1 and Interstitial collagenase inhibitor (2R)-2-[4... 4 1
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 2
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Cathepsin K and Cathepsin L1 inhibitor dipeptidyl nitrile, 16c... 1 0
Neprilysin inhibitor (2S)-4-methoxy-2-[[1-[[(1R,2S)-2-(4-metho... 1 0
Renin inhibitor ethyl N-[1-[[1-[[(2S,3R,4S)-1-cyclohexyl-3,4-d... 2 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 12
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor SureCN101... 2 6
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Stromelysin-1 inhibitor (2R)-2-[[(2S)-1-[(6S)-6-(methylcarbamo... 1 1
C-C chemokine receptor type 2 ligand (E)-N-[(1S,3R)-3-[[4-(4-m... 1 6
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Prothrombin inhibitor (2S)-N-[(4-aminocyclohexyl)methyl]-1-(2,... 1 0
Renin inhibitor (4S,5S,7S)-5-amino-N-butyl-7-[[4-tert-butyl-3-... 2 2
Dipeptidyl peptidase 4 inhibitor 3-[[2-[(2S,4S)-2-cyano-4-fluo... 5 1
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Substance-P receptor ligand (2S)-N-[(2S)-1-[benzyl(methyl)amin... 2 2
Beta-lactamase and Histone-lysine N-methyltransferase 2A inhib... 1 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 4
Metabotropic glutamate receptor 1 ligand methyl (2R)-2-[[(1aR,... 2 0
Endothelin-converting enzyme 1 inhibitor [[(2S)-5-(2,4-difluor... 1 0
Lysosomal alpha-glucosidase inhibitor MLS000587024 family 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN4877195 family 1 0
Carbonic anhydrase and Carbonic anhydrase 2 inhibitor 2-(3-chl... 2 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 2 0
Chymase and Chymotrypsinogen A inhibitor N-[(2S)-4-chloro-3-ox... 1 0
Putative NP ZINC14589285 Family 2 1
N-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-4-(4-methoxyphenyl)te... 2 0
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
Putative NP ZINC02099241 Family 12 0
(2S)-1-[2-[4-(8-methoxy-2-oxochromen-3-yl)phenoxy]acetyl]pyrro... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00256426 CHEMBL64013 Bioactive (3S,6R,7S)-7-N-hydroxy-3-N-methyl-6-[3-(4-methylphenyl)propyl]-5-oxo-12-oxa-4-azabicyclo[11.2.2]heptadeca-1(15),13,16-triene-3,7-dicarboxamide
CFAMM00256416 CHEMBL98770 Bioactive (3S,6R,7S)-6-[3-(4-ethoxyphenyl)propyl]-7-N-hydroxy-3-N-methyl-5-oxo-12-oxa-4-azabicyclo[11.2.2]heptadeca-1(15),13,16-triene-3,7-dicarboxamide
CFAMM00256421 DNC006448 Investigative Drug SR-973

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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