CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1989
Family Name Metabotropic glutamate receptor 5 Ligand 4-(4-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine Family
No. of Seeds 4 No. of Other Members 17
Family Centroid CFAMM00256455 Functional Category Investigative Drug
Superfamily Metabotropic glutamate receptor 5 Ligand 4-(4-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine Superfamily
Class Class 914

Cousin Family NamesSeedsMembers
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Mitogen-activated protein kinase 14 Inhibitor 9-benzyl-6-pheny... 5 33
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 5
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Histone-lysine N-methyltransferase 2A and Huntingtin inhibitor... 1 0
Nuclear receptor ROR-gamma and Lysine-specific demethylase 4E ... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-075XWO family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00256457 DNC006454 Investigative Drug 4-(3-bromophenylthio)-2-(pyridin-2-yl)pyrimidine
CFAMM00256456 DNC006455 Investigative Drug 4-(3-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine
CFAMM00256455 DNC006452 Investigative Drug 4-(4-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine
CFAMM00256454 DNC006453 Investigative Drug 2-(pyridin-2-yl)-4-(m-tolylthio)pyrimidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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