CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2003
Family Name Amyloid beta A4 protein Inhibitor 1,6-bis(4'-nitrophenyl)-hexa-1,3,5-triene Family
No. of Seeds 3 No. of Other Members 60
Family Centroid CFAMM00257000 Functional Category Investigative Drug
Superfamily Histamine H3 receptor and Amyloid beta A4 protein Binder Superfamily
Class Class 2177

Cousin Family NamesSeedsMembers
4-hydroxyphenylpyruvate dioxygenase Inhibitor Nitisinone Family 4 43
Poly [ADP-ribose] polymerase 1 Inhibitor BSI-201 Family 3 16
Beta-lactamase Inhibitor 3-nitrophenylboronic Acid Family 4 15
Alpha-2A adrenergic receptor Ligand 7-nitro-1,2,3,4-tetrahydro... 6 31
Carbonic anhydrase 2 Inhibitor 4-nitrophenylsulfamide Family 1 2
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
Sigma non-opioid intracellular receptor 1 ligand 1-[(3-nitroph... 4 2
5-hydroxytryptamine receptor 7 ligand 1-[2-(4-nitrophenyl)phen... 1 0
Progesterone receptor and Androgen receptor ligand SureCN89245... 1 4
Thyrotropin receptor and Cytochrome P450 3A4 ligand 2-Methyl-5... 1 10


External ID

Functional Category

Molecule Name

CFAMM00256958 CHEMBL114059 Bioactive 3-Nitrotoluene
CFAMM00256968 DNC010985 Investigative Drug 3-Nitro-4'-nitro-trans-stilbene
CFAMM00257000 DNC006517 Investigative Drug 1,6-bis(4'-nitrophenyl)-hexa-1,3,5-triene

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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