CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2008
Family Name Glutamate carboxypeptidase 2 Inhibitor 3-(2-carboxy-6-mercaptohexyl)benzoic Acid Family
No. of Seeds 9 No. of Other Members 4
Family Centroid CFAMM00257046 Functional Category Investigative Drug
Superfamily Glutamate carboxypeptidase 2 and Beta-lactamase Binder Superfamily
Class Class 1688

Cousin Family NamesSeedsMembers
Retinoid X receptor Ligand Bexarotene Family 7 492
Cyclooxygenase Inhibitor Flurbiprofen Family 18 294
Prostaglandin G/H synthase 2 Inhibitor Ketoprofen Family 5 84
DNA topoisomerase 2-beta Inhibitor Salvicine Family 2 9
CPI-613 family 4 35
Serine/threonine-protein kinase mTOR and K-RAS protein Inhibit... 2 20
Carbonic anhydrase 2 Inhibitor 4-(hydroxymercury)benzoic Acid ... 7 97
Nicotinate-nucleotide pyrophosphorylase [carboxylating] Inhibi... 2 119
Beta-lactamase Inhibitor 4-carboxyphenylboronic Acid Family 1 1
C-X-C chemokine receptor type 1 and C-X-C chemokine receptor t... 2 53
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,5-difluorophenyl)... 12 10
72 kDa type IV collagenase and Macrophage metalloelastase Inhi... 2 5
Glutamate carboxypeptidase 2 Inhibitor 2-(3-carboxybenzyl)succ... 2 7
Glutamate carboxypeptidase 2 Inhibitor 2-(3-cyanobenzyl)-5-mer... 1 0
Glutamate carboxypeptidase 2 Inhibitor 2-(3-carbamoylbenzyl)-5... 2 1
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Protein kinase C delta type and Protein kinase C alpha type In... 4 105
Fatty-acid amide hydrolase 1 Inhibitor 3-(ethoxycarbonyl)pheny... 2 69
Retinoic acid receptor gamma and Retinoic acid receptor beta l... 2 11
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 2 16
Arachidonate 15-lipoxygenase inhibitor SureCN9469035 family 6 40
Retinoic acid receptor beta and Retinoic acid receptor gamma l... 1 2
Prostaglandin E2 receptor EP2 subtype ligand 4-[2-[(1R,3R)-3-h... 1 6
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 18
Integrase inhibitor AGN-PC-00QHSA family 1 2
Tyrosine-protein phosphatase non-receptor type 1 ligand AGN-PC... 1 1
Indanes Metabolite (R)-Pterosin B Family 5 8
[(1S,2S,5R)-2-hydroxy-2-methyl-5-prop-1-en-2-ylcyclohexyl] ben... 1 2
(1S)-1-hydroxy-1,4-dimethyl-2,3-dihydrocyclopenta[b]anthracene... 1 1
carboxylate NP ZINC04026424 Family 3 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00257049 CHEMBL2152561 Bioactive 2-(3-carboxyphenyl)-6-(2-sulfanylethyl)benzoic acid
CFAMM00257048 CHEMBL2152562 Bioactive 2-(4-carboxyphenyl)-6-(2-sulfanylethyl)benzoic acid
CFAMM00257046 DNC006526 Investigative Drug 3-(2-carboxy-6-mercaptohexyl)benzoic acid
CFAMM00257045 DNC006527 Investigative Drug 3-(2-carboxy-4-mercaptobutyl)benzoic acid
CFAMM00257044 DNC006525 Investigative Drug 2-(2-carboxy-7-mercaptoheptyl)benzoic acid
CFAMM00257052 DNC006530 Investigative Drug 3-(2-carboxy-5-mercaptopentyl)benzoic acid
CFAMM00257043 DNC006528 Investigative Drug 3-(2-carboxy-3-mercaptopropyl)benzoic acid
CFAMM00257042 DNC006529 Investigative Drug 4-(2-carboxy-5-mercaptopentyl)benzoic acid
CFAMM00257047 DNC006531 Investigative Drug 2-(2-carboxy-5-mercaptopentyl)benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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