CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2013
Family Name Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibitor 6-phenyl-thieno[3,2-d]pyrimidin-4-ylamine Family
No. of Seeds 6 No. of Other Members 64
Family Centroid CFAMM00257122 Functional Category Investigative Drug
Superfamily Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibitor 6-phenyl-thieno[3,2-d]pyrimidin-4-ylamine Superfamily
Class Class 1151

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Transient receptor potential cation channel subfamily V member... 15 457
5-hydroxytryptamine receptor 3A Ligand DDP-225 Family 1 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 53
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 11
PF-3758309 family 1 8
Mitogen-activated protein kinase 14 Inhibitor 9-benzyl-6-pheny... 5 33
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Metabotropic glutamate receptor 5 Ligand 4-(4-chlorophenylthio... 4 17
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 3 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Histamine H4 receptor Ligand A-943931 Family 14 11
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Deoxycytidine kinase inhibitor AGN-PC-07Z9B3 family 2 7
Rho-associated protein kinase 1 inhibitor AGN-PC-04T4AX family 1 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 6 11
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine kinase inhibitor SureCN8183719 family 2 3
Epidermal growth factor receptor ligand AGN-PC-07C2E2 family 7 6
Cell division cycle 7-related protein kinase inhibitor AGN-PC-... 6 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 3 10
Histamine H4 receptor ligand 8-bromo-4-(4-methylpiperazin-1-yl... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 1
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 7 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 1
Epidermal growth factor receptor and Vascular endothelial grow... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck ligand... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 10
D(4) dopamine receptor and D(2) dopamine receptor ligand 3-(1-... 1 0
Vascular endothelial growth factor receptor 2 and Insulin rece... 2 0
Aurora kinase A and Vascular endothelial growth factor recepto... 1 1
Lysophosphatidic acid receptor 2 ligand N-[(2S)-1-[4-(3,4-dich... 2 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00257098 CHEMBL155278 Bioactive Benzothieno[3,2-d]pyrimidine deriv. 59
CFAMM00257145 CHEMBL357367 Bioactive AGN-PC-075SEK
CFAMM00257111 CHEMBL463119 Bioactive AGN-PC-009BKZ
CFAMM00257149 CHEMBL193286 Bioactive SureCN7974695
CFAMM00257100 CHEMBL348712 Bioactive SureCN8144222
CFAMM00257122 DNC006551 Investigative Drug 6-phenyl-thieno[3,2-d]pyrimidin-4-ylamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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