CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2020
Family Name C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-yl)quinolin-5-amine Family
No. of Seeds 3 No. of Other Members 9
Family Centroid CFAMM00257418 Functional Category Investigative Drug
Superfamily TGF-beta receptor type-1 and C-C chemokine receptor type 4 Binder Superfamily
Class Class 2183

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
mRNA of Glucagon receptor Ligand Isis 325568 Family 1 3
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Metabotropic glutamate receptor 5 Ligand N-[4-(3-pyridylethyny... 2 10
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(naphthalen-1-yl)-4-neo... 5 78
C-C chemokine receptor type 4 Ligand 4-tert-butyl-n-o-tolylthi... 4 7
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Mitogen-activated protein kinase 14 inhibitor 6-[3-amino-5-(2-... 4 9
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M88D fa... 2 1
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Neuropeptide Y receptor type 5 ligand N-[5-[(4-thiophen-3-yl-1... 1 4
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
5-hydroxytryptamine receptor 6 ligand 5-[3-(1-benzylpyrrolidin... 1 0
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-N-[... 3 0
Cholinesterase and Acetylcholinesterase inhibitor 3-[ethyl-[3-... 6 9
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
G1/S-specific cyclin-E1 and G1/S-specific cyclin-E2 inhibitor ... 5 1
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor 2-(4-hydroxy... 2 15
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 7 7
Glucocorticoid receptor ligand 3-(1H-indol-5-yl)-2,2-dimethyl-... 2 7
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00257416 DNC006580 Investigative Drug N-(4-tert-butylthiazol-2-yl)isoquinolin-5-amine
CFAMM00257427 DNC006579 Investigative Drug N-(4-tert-butylthiazol-2-yl)-1H-indol-4-amine
CFAMM00257418 DNC006581 Investigative Drug N-(4-tert-butylthiazol-2-yl)quinolin-5-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26240 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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