CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2023
Family Name Platelet-derived growth factor receptor alpha and Platelet-derived growth factor receptor beta Ligand Di(1h-indol-2-yl)methanone Family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00257514 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily 3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Binder Superfamily
Class Class 1284

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
CP-18770 family 6 27
Lethal factor Inhibitor GM6001 Family 50 435
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 16 0
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Serine/threonine-protein kinase Chk1 Inhibitor BIS-IMIDE A Family 1 3
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Kinesin-like protein KIF11 Inhibitor 9h-carbazole-2-carbaldehy... 1 3
Endothelin B receptor Ligand IRL-2500 Family 34 87
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Histone deacetylase Inhibitor ST-5732 Family 8 6
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00257512 DNC014609 Investigative Drug 2-Propionyl-1H-indole-6-carboxamidine
CFAMM00257515 DNC006592 Investigative Drug (5-fluoro-1H-indol-2-yl)-(1H-indol-2-yl)methanone
CFAMM00257514 DNC006598 Investigative Drug di(1H-indol-2-yl)methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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