CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2024
Family Name Platelet-derived growth factor receptor alpha and Platelet-derived growth factor receptor beta Ligand (1h-indol-2-yl)(6-methoxy-1h-indol-2-yl)methanone Family
No. of Seeds 2 No. of Other Members 13
Family Centroid CFAMM00257527 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Platelet-derived growth factor receptor beta and Receptor-type tyrosine-protein kinase FLT3 Binder Superfamily
Class Class 2321

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Indeglitazar family 3 39
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
AP endonuclease APE1 Inhibitor 5-fluoro-1h-indole-2-carboxylic... 2 61
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Platelet-derived growth factor receptor beta and Receptor-type... 1 2
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Aromatase Inhibitor MR-16089 Family 1 0
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 11
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-0759OR family 4 7
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 4-(benzyloxy... 1 10
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 1 8
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
Indoles Metabolite 7-Hydroxyheptaphylline Family 4 0
Indoles Metabolite Mukeic acid Family 1 1
Amino Acids and Derivatives Metabolite Flazine Family 3 2
Indoles Metabolite Koeniginequinone B Family 1 2
3-((4-methoxy-2-(methoxycarbonyl)-1H-indol-3-yl)carbamoyl)-2,2... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00257527 DNC006593 Investigative Drug (1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone
CFAMM00257523 DNC014570 Investigative Drug 2-(4-Methoxy-phenyl)-1H-indole-3-carbaldehyde

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26230 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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