CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2034
Family Name Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-ile-tyr-lys-phe(4-i)-tyr Family
No. of Seeds 36 No. of Other Members 12
Family Centroid CFAMM00257710 Functional Category Investigative Drug
Superfamily Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-ile-tyr-lys-phe(4-i)-tyr Superfamily
Class Class 2328

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Trypsin inhibitor polypeptide Aprotinin Family 7 68
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Oxytocin receptor Ligand Oxytocin Family 30 182
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Penicillin binding protein Inhibitor Cefadroxil Family 5 17
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Zucapsacin family 7 177
Thymopentin family 20 133
B2 bradykinin receptor Ligand Labradimil Family 1 1
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Thymosin Beta-4 family 8 30
Plitidepsin family 15 5
Flovagatran family 12 546
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Tryptase Inhibitor APC-366 Family 2 12
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Vasopeptidase Inhibitor Fasidotril Family 3 7
Neprilysin Inhibitor Thiorphan Family 41 68
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Neuromedin-K receptor Ligand Senktide Family 15 22
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Caspase-1 Inhibitor Yvad Family 1 0
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Kynureninase Inhibitor 3-hydroxyhippuric Acid Family 1 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU84687 F... 2 14
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cruzipain Inhibitor WRR-204 Family 18 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Somatostatin receptor type 1 Ligand Des-aa1,2,5-[(nalphame)lys... 16 11
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-tyr(me)-agly-i... 2 1
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Integrin beta-3 Inhibitor Lamifiban Family 3 4
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Prothrombin Inhibitor Bbs-arg-(d-pip)-gly-s-(gs)1-gly-hir Family 13 0
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Caspase-1 Inhibitor Z-vad-cho Family 8 34
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 9 43
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 8
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 3 0
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Pol polyprotein inhibitor 180968-31-4 family 8 13
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 9
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 2 2
Interstitial collagenase and Low affinity immunoglobulin epsil... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (3S,6R,11R,14S)... 1 0
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Neprilysin and Aminopeptidase N inhibitor benzyl 2-[[(2S)-2-[[... 1 1
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Transient receptor potential cation channel subfamily V member... 3 18
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Pol polyprotein inhibitor benzyl N-[(2S,3R)-4-[(3aR,6S,7aS)-6-... 3 2
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6368456 f... 3 23
Neprilysin inhibitor SureCN389939 family 5 6
Tyrosine--tRNA ligase, cytoplasmic inhibitor (2S)-2-[[(2S)-2-a... 5 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[4-(ben... 12 20
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-074GDW f... 9 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6453971 f... 3 4
Pol polyprotein inhibitor AC1LADQG family 7 1
Pol polyprotein inhibitor MDL 74538 family 11 1
Plasminogen inhibitor (2S)-2-acetamido-5-(diaminomethylideneam... 1 0
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E)... 1 0
Oxytocin receptor ligand (2S)-N-[(2R)-1-[2-[[5-amino-1-[[1-ami... 4 0
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Metallo-beta-lactamase L1 inhibitor 3-[[1-[[(2R)-1-amino-1-oxo... 1 0
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Neurotensin receptor type 1 ligand (2S)-2-[[(2S,3S)-2-[[(2S)-2... 2 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diami... 2 0
C-X-C chemokine receptor type 4 ligand CHEMBL2372990 family 3 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(3-hydroxyp... 4 1
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R,6S,12S)-6... 7 0
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 5 2
Neprilysin inhibitor benzyl (2S)-3-(4-hydroxyphenyl)-2-[[2-(su... 1 1
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Angiotensin-converting enzyme inhibitor Rentiapril family 1 7
Prothrombin inhibitor (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]... 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Neprilysin inhibitor (2S)-4-methoxy-2-[[1-[[(1R,2S)-2-(4-metho... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Gonadotropin-releasing hormone receptor ligand (3R,6S,12S,15S,... 1 0
N-acetylated-alpha-linked acidic dipeptidase 2 inhibitor (2S)-... 1 5
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
Sodium-dependent dopamine transporter inhibitor AC1MIIGH family 2 0
Beta-lactamase inhibitor sodium;(1R,5S)-4-[2-amino-2-(4-hydrox... 1 0
Signal transducer and activator of transcription 3 inhibitor [... 7 25
Growth factor receptor-bound protein 2 ligand 2-[[(9S,12S,15S,... 2 3
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-076B5T fa... 1 0
Aminopeptidase N and Cytosol aminopeptidase inhibitor AGN-PC-0... 1 0
Growth factor receptor-bound protein 2 ligand 2-[[(5S,8S,11S,1... 2 0
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1
Pol polyprotein inhibitor AC1MHYEO family 1 0
N-formyl-2-(4-hydroxyphenyl)acetamide NP Agn-pc-04a0ox Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00257695 CHEMBL11616 Bioactive AGN-PC-024W3D
CFAMM00257708 CHEMBL19070 Bioactive (2S)-3-(4-hydroxyphenyl)-2-[[(2S,3S)-3-methyl-2-[[(2S)-2-phenyl-2-sulfanylacetyl]amino]pentanoyl]amino]propanoic acid
CFAMM00257701 CHEMBL21025 Bioactive (2S)-3-(4-hydroxyphenyl)-2-[[(2S)-2-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]hexanoyl]amino]propanoic acid
CFAMM00257694 CHEMBL19494 Bioactive (2S)-3-(4-hydroxyphenyl)-2-[[(2S)-4-methyl-2-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]pentanoyl]amino]propanoic acid
CFAMM00257687 CHEMBL277238 Bioactive TI2
CFAMM00257700 CHEMBL19755 Bioactive (2S)-3-(4-hydroxyphenyl)-2-[[(2S,3S)-3-methyl-2-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]pentanoyl]amino]propanoic acid
CFAMM00257693 CHEMBL19165 Bioactive (2S)-3-(4-hydroxyphenyl)-2-[[(2S)-2-[[(2S,3S)-3-methyl-2-sulfanylpentanoyl]amino]-3-phenylpropanoyl]amino]propanoic acid
CFAMM00257705 CHEMBL279966 Bioactive (2S)-3-(4-hydroxyphenyl)-2-[[(2S)-3-methyl-2-[[(2S)-4-phenyl-2-sulfanylbutanoyl]amino]butanoyl]amino]propanoic acid
CFAMM00257698 CHEMBL278289 Bioactive (4S)-4-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-sulfanylbutanoyl]amino]-3-phenylpropanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
CFAMM00257691 CHEMBL2370368 Bioactive (4R,7S,13S)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-7-benzyl-3,3-dimethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
CFAMM00257704 CHEMBL426697 Bioactive YSTCYFIM
CFAMM00257697 CHEMBL39562 Bioactive (4R,7S,10R)-10-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3,3-dimethyl-7-[(4-methylphenyl)methyl]-6,9-dioxo-1,2-dithia-5,8-diazacycloundecane-4-carboxylic acid
CFAMM00257690 CHEMBL20067 Bioactive (2S)-3-(4-hydroxyphenyl)-2-[[(2S)-3-methyl-2-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]butanoyl]amino]propanoic acid
CFAMM00257696 CHEMBL2370370 Bioactive (4S,7S,13S)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-7-benzyl-3,3-dimethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
CFAMM00257707 DNC006633 Investigative Drug Ac-Cys-Ile-Tyr-Lys-Phe(4-Cl)-Tyr
CFAMM00257711 DNC006625 Investigative Drug Ac-Cys-Ile-Tyr-Lys-Phe(4-CN)-Tyr
CFAMM00257710 DNC006626 Investigative Drug Ac-Cys-Ile-Tyr-Lys-Phe(4-I)-Tyr

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27043 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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