CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID204
Family Name Delta-type opioid receptor Ligand Bw 373u86 Family
No. of Seeds 31 No. of Other Members 146
Family Centroid CFAMM00184048 Functional Category Investigative Drug with Natural Product
Superfamily Delta-type opioid receptor and Tyrosine-protein kinase SYK Binder Superfamily
Class Class 517

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Zucapsacin family 7 177
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Elagolix family 43 98
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Poly [ADP-ribose] polymerase 1 Inhibitor 3-methoxybenzamide Fa... 2 23
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 3
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 14
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
D(2) dopamine receptor Ligand Epidepride Family 31 66
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 4 7
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 2 3
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 7 5
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745OX family 2 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Prothrombin inhibitor N-cyclohexyl-3-[3-(diaminomethylideneami... 3 4
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 26 12
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-[4-... 30 10
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Histamine H1 receptor and Histamine H3 receptor ligand 4-[(4-m... 3 6
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[(... 5 2
Sigma non-opioid intracellular receptor 1 and Vesicular acetyl... 3 7
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Mu-type opioid receptor ligand AGN-PC-075GAC family 16 8
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Melanin-concentrating hormone receptor 1 ligand (3S)-3-[[5-(4-... 4 5
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 4
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Histamine H3 receptor ligand 1-methyl-5-[4-[3-[(2R)-2-methylpy... 5 5
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 1 1
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 3 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 1
5-hydroxytryptamine receptor 1A ligand (3S)-3-[4-(7,9-dioxo-8-... 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 2 6
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
Pol polyprotein inhibitor 168912-67-2 family 1 0
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Coagulation factor X inhibitor 3-[4-[[(E)-3-[3-(diaminomethyli... 4 6
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 4
Chymase inhibitor 1,3-bis[(3-methoxyphenyl)methyl]-1,3-diazeti... 3 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Motilin receptor and Growth hormone secretagogue receptor type... 1 2
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Neuromedin-K receptor ligand SureCN2478117 family 1 0
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 5 7
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor AGN-PC-00... 5 14
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 1 1
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-ben... 1 0
Potassium voltage-gated channel subfamily H member 2 ligand [4... 1 1
5-lipoxygenase inhibitor 6-(1,8-dihydroxy-9-oxo-10H-anthracen-... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00183998 CHEMBL111656 Bioactive 4-[(R)-[(2S,5R)-4-butyl-2,5-dimethylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide
CFAMM00184098 CHEMBL67996 Bioactive AGN-PC-005OFB
CFAMM00184112 CHEMBL605931 Bioactive AGN-PC-03TYF0
CFAMM00183982 CHEMBL111389 Bioactive N,N-diethyl-4-[(R)-[(2S,5R)-4-ethyl-2,5-dimethylpiperazin-1-yl]-(3-methoxyphenyl)methyl]benzamide
CFAMM00183997 CHEMBL431276 Bioactive 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N-ethyl-N-methylbenzamide
CFAMM00184177 CHEMBL2374437 Bioactive N,N-diethyl-4-[(R)-(3-methoxyphenyl)-(4-prop-2-enylpiperazin-1-yl)methyl]benzamide
CFAMM00184040 CHEMBL2436051 Bioactive AGN-PC-09OUW9
CFAMM00184097 CHEMBL430675 Bioactive azepan-1-yl-[4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-methoxyphenyl)methyl]phenyl]methanone
CFAMM00184148 CHEMBL98800 Bioactive 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-di(propan-2-yl)benzamide
CFAMM00184125 CHEMBL2434980 Bioactive AGN-PC-0CCC0Y
CFAMM00183988 CHEMBL303855 Bioactive AC1L1DSZ
CFAMM00184169 CHEMBL108659 Bioactive 4-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide
CFAMM00184046 CHEMBL69052 Bioactive SureCN6934906
CFAMM00184147 CHEMBL108993 Bioactive 4-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-methylprop-2-enyl)piperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide
CFAMM00184109 CHEMBL67195 Bioactive SureCN6933968
CFAMM00184070 CHEMBL2436056 Bioactive AGN-PC-0CCC0A
CFAMM00184101 CHEMBL611159 Bioactive 4-[(S)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide
CFAMM00184130 CHEMBL108543 Bioactive 4-[(R)-[(2S,5R)-2,5-dimethyl-4-pentylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide
CFAMM00184044 CHEMBL323733 Bioactive N,N-diethyl-4-[(R)-(3-methoxyphenyl)-[(2S,5R)-2,4,5-trimethylpiperazin-1-yl]methyl]benzamide
CFAMM00184062 CHEMBL348415 Bioactive 3-[(S)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide
CFAMM00184076 CHEMBL2436050 Bioactive AGN-PC-09OUW7
CFAMM00184173 CHEMBL108874 Bioactive 4-[(R)-[(2S,5R)-4-[(E)-but-2-enyl]-2,5-dimethylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide
CFAMM00184151 CHEMBL320356 Bioactive 4-[(R)-[(2S,5R)-4-(cyclopropylmethyl)-2,5-dimethylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide
CFAMM00184090 CHEMBL70111 Bioactive SureCN232384
CFAMM00184048 DNC000362 Investigative Drug BW 373U86
CFAMM00184153 DNC001348 Investigative Drug SNC-80

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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