CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2041
Family Name Cyclin-dependent kinase 2 and Mitogen-activated protein kinase 10 Inhibitor N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide Family
No. of Seeds 7 No. of Other Members 30
Family Centroid CFAMM00257851 Functional Category Investigative Drug with Natural Product
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 5
Class Class 1373

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Type-1 angiotensin II receptor Ligand Tasosartan Family 10 29
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Tubulin beta chain Inhibitor 7-methyl-2-m-tolyl-1h-[1,8]naphth... 7 15
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Metabotropic glutamate receptor 5 Ligand 3-(1-pyridin-2-yl-1h-... 3 6
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(6-chlorop... 2 5
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(6-methylpy... 4 3
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-amin... 2 30
Cathepsin K Inhibitor 2-cyclohexylamino-pyridine-2-carbonitril... 1 2
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Urotensin-2 receptor Ligand Palosuran Family 4 4
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-(4-cy... 1 0
Bloom syndrome protein inhibitor SR 57227A family 2 12
Cathepsin K and Potassium voltage-gated channel subfamily H me... 3 1
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Survival motor neuron protein inhibitor CHEMBL1581561 family 1 3
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Corticotropin-releasing factor receptor 1 ligand 2-[butyl-[4-[... 9 9
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... 7 6
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Dihydrofolate reductase inhibitor 1-[3-(2,4-diaminoquinazolin-... 2 4
Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-008HTV... 2 1
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 1
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... 1 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 4 4
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 6
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 6 6
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 7
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor 5-ami... 2 0
Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00257844 CHEMBL227946 Bioactive Pyridopyrazinone, 4a
CFAMM00257831 CHEMBL440416 Bioactive N-(5-cyano-4,6-diphenylpyrimidin-2-yl)-2-methylpropanamide
CFAMM00257799 CHEMBL260890 Bioactive N-(5-cyano-2,6-diphenylpyrimidin-4-yl)cyclopentanecarboxamide
CFAMM00257821 CHEMBL506129 Bioactive AGN-PC-077RW1
CFAMM00257820 CHEMBL258989 Bioactive N-(5-cyano-4,6-diphenylpyrimidin-2-yl)-2-ethylbutanamide
CFAMM00257833 CHEMBL259075 Bioactive N-(5-cyano-4,6-diphenylpyrimidin-2-yl)butanamide
CFAMM00257851 DNC006663 Investigative Drug N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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