CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2043
Family Name D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-(1h-pyrazol-1-yl)benzyl)-4-phenylpiperazine Family
No. of Seeds 10 No. of Other Members 48
Family Centroid CFAMM00257929 Functional Category Investigative Drug
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 6
Class Class 1034

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
Glucagon receptor Ligand Dwlip-gcgrrx Family 5 26
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Interleukin-1 beta and Interleukin-6 Inhibitor Ibudilast Family 2 11
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
PF-4217903 family 14 65
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand FK-838... 4 19
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
Acetylcholinesterase Inhibitor 3-[2-(1-benzyl-piperidin-4-yl)-... 2 9
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 6
Calcium-activated potassium channel subunit alpha-1 Ligand 1-(... 3 3
Glucocorticoid receptor and Oxysterols receptor LXR-alpha Liga... 4 13
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Translocator protein Inhibitor 5-phenyl-6-thia-10b-aza-benzo[e... 1 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 6
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YT9... 28 20
Corticotropin-releasing factor receptor 1 ligand 3,7-dimethyl-... 3 4
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUB... 2 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YYL... 1 3
Acetylcholinesterase and Cholinesterase inhibitor 3,8-DIAMINO-... 2 3
Smoothened homolog inhibitor AC1P6IWE family 1 0
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Tyrosine-protein kinase ITK/TSK inhibitor (3Z)-3-(6-methylindo... 2 40
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Androgen receptor ligand 2-chloro-4-[4-[(4-fluorophenyl)methyl... 2 11
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
5-hydroxytryptamine receptor 7 ligand AS-19 (drug) family 1 1
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Motilin receptor ligand SureCN2004322 family 2 1
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 3 0
Casein kinase I isoform delta and Casein kinase I isoform epsi... 1 0
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Glucocorticoid receptor ligand 1-[(4aS)-6-(4-tert-butylphenyl)... 27 3
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Glucocorticoid receptor ligand 6-benzyl-1-(4-fluorophenyl)-4a-... 2 0
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 1
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
Progesterone receptor ligand AGN-PC-074LWG family 1 1
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 2
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Thromboxane-A synthase inhibitor AGN-PC-07BYVF family 1 0
Nociceptin receptor ligand SureCN3543370 family 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Transient receptor potential cation channel subfamily V member... 1 0
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
TGF-beta receptor type-1 ligand 6-bromo-4-(2-(6-methylpyridin-... 1 3
TGF-beta receptor type-1 ligand SureCN373106 family 4 1
Extracellular calcium-sensing receptor ligand SureCN2220343 fa... 1 0
Farnesyl pyrophosphate synthase inhibitor AGN-PC-080IBX family 2 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 4
1,5-dioxidopyrrolo[3,2-c]pyridin-5-ium NP Agn-pc-0639xa Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00257908 CHEMBL279247 Bioactive SureCN8484659
CFAMM00257882 CHEMBL25772 Bioactive SureCN8481000
CFAMM00257929 DNC006668 Investigative Drug 1-(4-(1H-pyrazol-1-yl)benzyl)-4-phenylpiperazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27058 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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