CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID205
Family Name Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family
No. of Seeds 12 No. of Other Members 8
Family Centroid CFAMM00184178 Functional Category Investigative Drug
Superfamily D(1A) dopamine receptor and Arachidonate 5-lipoxygenase Binder Superfamily
Class Class 719

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Delta-type opioid receptor ligand opiate analog Codeine Family 15 184
u-type opioid receptor ligand opiate analog Buprenorphine Family 78 234
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
D(3) dopamine receptor Ligand U-99194A Family 7 33
Vernakalant family 1 1
Acolbifene family 10 115
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
M-phase inducer phosphatase 3 Inhibitor BN-82002 Family 1 3
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 20 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 7 4
Transient receptor potential cation channel subfamily V member... 14 7
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 2 0
Histamine H1 receptor ligand Ahr 5333 family 1 6
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 2 1
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 10 8
Sodium-dependent noradrenaline transporter and Cytochrome P450... 11 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00184198 CHEMBL489621 Bioactive SureCN7898679
CFAMM00184206 CHEMBL515472 Bioactive (R)-[3-(2-fluoroethoxy)-2-methoxyphenyl]-[1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl]methanol
CFAMM00184197 CHEMBL492069 Bioactive AGN-PC-077NSO
CFAMM00184196 CHEMBL490846 Bioactive AGN-PC-077NRZ
CFAMM00184204 CHEMBL402143 Bioactive [3-(2-fluoroethoxy)-2-methoxyphenyl]-[1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl]methanol
CFAMM00184184 CHEMBL476839 Bioactive AGN-PC-077NQI
CFAMM00184183 CHEMBL96714 Bioactive AGN-PC-072OZH
CFAMM00184202 CHEMBL489634 Bioactive AGN-PC-077NT8
CFAMM00184199 CHEMBL490847 Bioactive SureCN5968578
CFAMM00184194 DNC000911 Investigative Drug M100907
CFAMM00184178 DNC000363 Investigative Drug BW A360C

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27425 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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