CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID2053
Family Name RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 Family
No. of Seeds 67 No. of Other Members 59
Family Centroid CFAMM00258297 Functional Category Investigative Drug with Natural Product
Superfamily D(2) dopamine receptor and RAC-gamma serine/threonine-protein kinase Binder Superfamily
Class Class 970

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Hepatocyte growth factor receptor and Proto-oncogene tyrosine-... 2 15
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Apricoxib family 8 77
Indeglitazar family 3 39
Grt 6005/06 family 4 22
PF-02545920 family 16 140
Fibroblast growth factor receptor Ligand LY2874455 Family 1 1
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Tyrosine kinase Inhibitor PKI166 Family 17 198
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 0
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Progesterone receptor Ligand PF-02367982 Family 2 8
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... 5 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Acetyl-CoA carboxylase 1 inhibitor AGN-PC-07ZCNM family 7 50
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 4
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Translocator protein inhibitor SureCN13502542 family 20 2
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Sigma non-opioid intracellular receptor 1 ligand 1'-butyl-6-me... 23 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Smoothened homolog inhibitor AGN-PC-088VBV family 1 2
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Pol polyprotein and Cytochrome P450 3A4 inhibitor P3 arylpyrro... 19 1
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 15
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 2
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 3 0
Coagulation factor X and Prothrombin inhibitor AGN-PC-0759SH f... 5 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Somatostatin receptor type 2 ligand SureCN4317006 family 10 1
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 1
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Glucocorticoid receptor ligand [(4aR,5S)-1-(4-fluorophenyl)-4a... 7 1
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN6575591... 2 0
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2489170 f... 8 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Platelet-derived growth factor receptor beta and Receptor-type... 1 2
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Beta-3 adrenergic receptor ligand 6-[4-[2-[[(2S)-3-[(3,3-dimet... 6 7
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Platelet-derived growth factor receptor beta and Macrophage co... 8 0
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 6-[5-[(2S)... 1 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Beta-secretase 1 inhibitor (5S)-3'-(3,4-difluorophenyl)-7'-(2-... 4 0
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 inhibi... 1 2
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Prostaglandin D2 receptor 2 ligand 2-[4-(difluoromethoxy)-2-et... 1 0
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Vascular endothelial growth factor receptor 1 and Vascular end... 5 22
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 7
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Acetylcholinesterase and Cholinesterase inhibitor CHEMBL237591... 1 1
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 4
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 4-[1-... 1 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Serine/threonine-protein kinase Chk1 inhibitor SureCN4806204 f... 13 7
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4814441 f... 4 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN4817112 f... 2 0
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Transient receptor potential cation channel subfamily V member... 6 1
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Renin inhibitor SureCN6043852 family 2 0
Renin inhibitor SureCN6042213 family 2 3
Renin inhibitor SureCN6044003 family 1 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
D(2) dopamine receptor ligand SureCN10575660 family 1 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Substance-P receptor ligand SureCN2139814 family 7 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Glucagon receptor ligand SureCN2647807 family 3 7
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 3-(hydroxy... 1 0
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 2 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Coagulation factor X inhibitor AGN-PC-046RMQ family 1 0
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04UHB... 4 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Rho-associated protein kinase 2 inhibitor SureCN13457632 family 1 1
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
B2 bradykinin receptor ligand SureCN13145573 family 7 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
Protein kinase C theta type and Protein kinase C delta type in... 5 4
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Collagenase 3 inhibitor SureCN1316041 family 4 3
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Nischarin inhibitor SureCN7810370 family 1 0
RAC-alpha serine/threonine-protein kinase and Rho-associated p... 1 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Tyrosine-protein kinase ITK/TSK inhibitor N-[(3Z)-3-(6-methoxy... 2 4
Dual specificity mitogen-activated protein kinase kinase 1 inh... 8 7
DNA gyrase subunit B and DNA gyrase subunit A inhibitor (1S,2R... 4 6
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8798759 f... 1 0
Caspase-3 and Caspase-7 inhibitor (2S)-N-[(3S)-2-hydroxy-5-oxo... 4 1
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
Amino Acids and Derivatives Metabolite Flazine Family 3 2
NP N-(1h-indol-6-yl)-3-(4-methoxy-1h-indol-1-yl)propanamide Fa... 2 0
NP N1-(5-bromo-1-ethyl-2-oxoindolin-3-yl)-N2-(2-(5-methoxy-1H-... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00258307 CHEMBL229855 Bioactive indazole-pyridine, 13l
CFAMM00258372 CHEMBL573359 Bioactive (2S)-1-(4-fluoro-3-methylphenyl)-3-[5-(3-methyl-2H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yl]oxypropan-2-amine
CFAMM00258387 CHEMBL226625 Bioactive indazole-pyridine, 13ac
CFAMM00258418 CHEMBL577795 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-1H-indazol-3-amine
CFAMM00258335 CHEMBL227367 Bioactive indazole-pyridine, 13t
CFAMM00258401 CHEMBL208790 Bioactive 5-indazolyl pyridine 11a
CFAMM00258365 CHEMBL594309 Bioactive (2S)-1-(7-fluoro-1H-indol-3-yl)-3-[6-(furan-3-yl)-5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine
CFAMM00258328 CHEMBL229314 Bioactive indazole-pyridine, 13a
CFAMM00258341 CHEMBL574764 Bioactive SureCN6854548
CFAMM00258409 CHEMBL226148 Bioactive indazole-pyridine, 2
CFAMM00258320 CHEMBL210403 Bioactive 5-indazolyl pyridine 11e
CFAMM00258334 CHEMBL227368 Bioactive indazole-pyridine, 13v
CFAMM00258417 CHEMBL227050 Bioactive indazole-pyridine, 13z
CFAMM00258408 CHEMBL227322 Bioactive indazole-pyridine, 13ah
CFAMM00258312 CHEMBL375919 Bioactive indazole-pyridine, 13n
CFAMM00258327 CHEMBL229799 Bioactive indazole-pyridine, 13h
CFAMM00258378 CHEMBL390372 Bioactive indazole-pyridine, 13k
CFAMM00258392 CHEMBL226996 Bioactive indazole-pyridine, 13w
CFAMM00258423 CHEMBL427422 Bioactive pyrazolopyridine-pyridine, 37d
CFAMM00258340 CHEMBL438483 Bioactive indazole-pyridine, 13b
CFAMM00258385 CHEMBL226627 Bioactive indazole-pyridine, 13af
CFAMM00258318 CHEMBL574995 Bioactive SureCN6855703
CFAMM00258399 CHEMBL576733 Bioactive SureCN6855764
CFAMM00258416 CHEMBL263510 Bioactive 5-indazolyl pyridine 11b
CFAMM00258363 CHEMBL226577 Bioactive indazole-pyridine, 13ab
CFAMM00258406 CHEMBL573133 Bioactive (2S)-1-(5-fluoro-2-methylphenyl)-3-[5-(3-methyl-2H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yl]oxypropan-2-amine
CFAMM00258384 CHEMBL226745 Bioactive indazole-pyridine, 13at
CFAMM00258332 CHEMBL605528 Bioactive (2S)-1-(5-fluoro-1H-indol-3-yl)-3-[6-(furan-3-yl)-5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine
CFAMM00258415 CHEMBL210349 Bioactive 5-indazolyl pyridine 11d
CFAMM00258376 CHEMBL574087 Bioactive SureCN6854290
CFAMM00258310 CHEMBL229918 Bioactive indazole-pyridine, 13p
CFAMM00258325 CHEMBL595939 Bioactive SureCN4792098
CFAMM00258405 CHEMBL376394 Bioactive indazole-pyridine, 13y
CFAMM00258338 CHEMBL595709 Bioactive SureCN4660705
CFAMM00258355 CHEMBL572908 Bioactive (2S)-1-(6-ethyl-5-isoquinolin-6-ylpyridin-3-yl)oxy-3-(1H-indol-3-yl)propan-2-amine
CFAMM00258421 CHEMBL375717 Bioactive indazole-pyridine, 13ai
CFAMM00258368 CHEMBL560377 Bioactive 3hqz
CFAMM00258348 CHEMBL574262 Bioactive oxindole pyridine, 9p
CFAMM00258375 CHEMBL209513 Bioactive Isoquinoline-pyridine, 10c
CFAMM00258309 CHEMBL229917 Bioactive indazole-pyridine, 13o
CFAMM00258324 CHEMBL579246 Bioactive oxindole pyridine, 9e
CFAMM00258354 CHEMBL572907 Bioactive SureCN6855403
CFAMM00258420 CHEMBL211827 Bioactive 5-isoquinolinyl pyridine 10b
CFAMM00258315 CHEMBL576372 Bioactive (2S)-1-[5-(3-methyl-2H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yl]oxy-3-[3-(piperidin-4-ylmethoxy)phenyl]propan-2-amine
CFAMM00258396 CHEMBL607374 Bioactive (2S)-1-(6-fluoro-1H-indol-3-yl)-3-[6-(furan-3-yl)-5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine
CFAMM00258330 CHEMBL594517 Bioactive (6Z)-6-[5-[(2S)-2-amino-3-phenylpropoxy]-3-(3-methyl-2H-indazol-5-yl)-1H-pyridin-2-ylidene]-4-fluorocyclohexa-2,4-dien-1-one
CFAMM00258346 CHEMBL210740 Bioactive 5-indazolyl pyridine 11c
CFAMM00258411 CHEMBL573592 Bioactive (2S)-1-(3-fluorophenyl)-3-[5-(3-methyl-2H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yl]oxypropan-2-amine
CFAMM00258336 CHEMBL227366 Bioactive indazole-pyridine, 13s
CFAMM00258419 CHEMBL229320 Bioactive indazole-pyridine, 13m
CFAMM00258366 CHEMBL575427 Bioactive (2S)-1-(4-fluoro-2-methylphenyl)-3-[5-(3-methyl-2H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yl]oxypropan-2-amine
CFAMM00258300 CHEMBL227271 Bioactive indazole-pyridine, 13al
CFAMM00258314 CHEMBL225789 Bioactive indazole-pyridine, 9e
CFAMM00258380 CHEMBL572670 Bioactive (2S)-1-(1H-indol-3-yl)-3-[5-[(3Z)-3-pyrrol-2-ylidene-1,2-dihydroindazol-5-yl]pyridin-3-yl]oxypropan-2-amine
CFAMM00258410 CHEMBL229968 Bioactive indazole-pyridine, 13q
CFAMM00258297 DNC006711 Investigative Drug A-443654

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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