CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2057
Family Name Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(6-methylpyridin-2-yl)benzamide Family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00258445 Functional Category Investigative Drug
Superfamily Tubulin beta chain and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 148

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
Class II cytokine receptor Ligand IL-10 Family 7 45
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
Tubulin beta chain Inhibitor 7-methyl-2-m-tolyl-1h-[1,8]naphth... 7 15
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(6-chlorop... 2 5
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Substance-P receptor ligand Netupitant family 5 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN14726714... 4 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Cannabinoid receptor 2 ligand AGN-PC-00SRU5 family 2 0
Glucocorticoid receptor ligand 5-[(6-methylpyridin-2-yl)methyl... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00258445 DNC006723 Investigative Drug 3-cyano-N-(6-methylpyridin-2-yl)benzamide
CFAMM00258443 DNC014419 Investigative Drug 3-cyano-N-(6-ethylpyridin-2-yl)-5-fluorobenzamide
CFAMM00258448 DNC006724 Investigative Drug 3-iodo-N-(6-methylpyridin-2-yl)benzamide
CFAMM00258446 DNC006722 Investigative Drug 3-bromo-N-(6-methylpyridin-2-yl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

44495 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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