CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2066
Family Name Delta-type opioid receptor and Mu-type opioid receptor Ligand H-dmt-aba-gly-nh-ph Family
No. of Seeds 12 No. of Other Members 46
Family Centroid CFAMM00258636 Functional Category Investigative Drug with Natural Product
Superfamily Mu-type opioid receptor and Delta-type opioid receptor Binder Superfamily 4
Class Class 2342

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Oxytocin receptor Ligand Oxytocin Family 30 182
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Prostaglandin G/H synthase 2 Inhibitor Mefenamic Acid Family 7 137
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Thymopentin family 20 133
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Tryptase Inhibitor APC-366 Family 2 12
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU84687 F... 2 14
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Tyrosine-protein kinase SYK Inhibitor N-benzyl-4-(2,5-dihydrox... 1 4
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Substance-K receptor Ligand MEN-14933 Family 13 154
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 9 43
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Beta-secretase 1 Inhibitor KMI-538 Family 4 20
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(ethylamino)naphthal... 10 13
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 3 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 4 1
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 1 0
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Growth factor receptor-bound protein 2 ligand (3-aminophenyl)m... 5 13
Serine/threonine-protein kinase Chk1 inhibitor N-[2-(dimethyla... 8 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Cathepsin L1 and Cathepsin K inhibitor benzyl N-[(2S)-4-methyl... 8 22
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[1-[2-[4-[(2... 2 8
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Vasopressin V1a receptor ligand (10S,13S,16S,19S,22S)-N-[(2S)-... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 0
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 22
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 12 13
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C8 liga... 2 0
Neurotensin receptor type 1 ligand (2S)-2-[[(2S,3S)-2-[[(2S)-2... 2 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 1 2
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(3-hydroxyp... 4 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 2 6
Neuropeptide Y receptor type 1 ligand SureCN8354018 family 2 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Prothrombin inhibitor (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]... 2 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(3-hydr... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
N-acetylated-alpha-linked acidic dipeptidase 2 inhibitor (2S)-... 1 5
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
fMet-Leu-Phe receptor ligand 2-[[(2S)-2-[[(2S)-2-[(4-methoxyph... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2-chlo... 2 0
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 1 1
fMet-Leu-Phe receptor ligand N-[2-(2,6-dimethylanilino)-1-(2,3... 1 2
Matrix metalloproteinase-9 and Metalloproteinase inhibitor 3 i... 6 2
Matrix metalloproteinase-9 and Metalloproteinase inhibitor 3 i... 1 3
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00258656 CHEMBL325702 Bioactive (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-(naphthalen-1-ylamino)-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00258673 CHEMBL227170 Bioactive N-[4-[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]phenyl]phenyl]-N'-hydroxyoctanediamide
CFAMM00258671 CHEMBL120091 Bioactive (2S)-1-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-N-[(2S)-1-anilino-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00258676 DNC014120 Investigative Drug Tyr-D-Ala-Gly-NMePhe
CFAMM00258636 DNC006748 Investigative Drug H-Dmt-Aba-Gly-NH-Ph

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46086 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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