CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2068
Family Name Delta-type opioid receptor and Mu-type opioid receptor Ligand H-dmt-tic-d-asp-n(me)-ph Family
No. of Seeds 36 No. of Other Members 15
Family Centroid CFAMM00258715 Functional Category Investigative Drug
Superfamily Mu-type opioid receptor and Delta-type opioid receptor Binder Superfamily 4
Class Class 2342

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Oxytocin receptor Ligand Oxytocin Family 30 182
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Thymopentin family 20 133
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Tryptase Inhibitor APC-366 Family 2 12
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU84687 F... 2 14
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 9 43
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Beta-secretase 1 Inhibitor KMI-538 Family 4 20
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(ethylamino)naphthal... 10 13
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 3 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 4 1
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Sigma non-opioid intracellular receptor 1 ligand CHEMBL154452 ... 2 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
Cathepsin L1 and Cathepsin K inhibitor benzyl N-[(2S)-4-methyl... 8 22
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[1-[2-[4-[(2... 2 8
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 0
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 2 1
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 22
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 12 13
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 7
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(3-hydr... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
fMet-Leu-Phe receptor ligand N-[2-(2,6-dimethylanilino)-1-(2,3... 1 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Cyclin-dependent kinase 4 inhibitor SureCN13343915 family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00258722 CHEMBL1649946 Bioactive (2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-3-(4-fluorophenyl)-1-oxo-1-[4-(N-propanoylanilino)piperidin-1-yl]propan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
CFAMM00258737 CHEMBL1649939 Bioactive (2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-oxo-3-phenyl-1-[4-(N-propanoylanilino)piperidin-1-yl]propan-2-yl]hexanamide
CFAMM00258701 CHEMBL2028972 Bioactive (3S)-N-[(2S)-6-amino-1-anilino-1-oxohexan-2-yl]-2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00258736 CHEMBL1649938 Bioactive (2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[2-oxo-2-[[(2S)-1-oxo-3-phenyl-1-[4-(N-propanoylanilino)piperidin-1-yl]propan-2-yl]amino]ethyl]hexanamide
CFAMM00258721 CHEMBL1649947 Bioactive (3R)-2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-N-[2-[[(2S)-3-(4-fluorophenyl)-1-oxo-1-[4-(N-propanoylanilino)piperidin-1-yl]propan-2-yl]amino]-2-oxoethyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00258720 CHEMBL392185 Bioactive 4-anilidopiperidine, 16
CFAMM00258712 CHEMBL80463 Bioactive 1-[[(3S)-2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-3,4-dihydro-1H-isoquinolin-3-yl]methyl]-3-phenylurea
CFAMM00258725 CHEMBL1649941 Bioactive (2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[2-[[(2S)-3-(4-chlorophenyl)-1-oxo-1-[4-(N-propanoylanilino)piperidin-1-yl]propan-2-yl]amino]-2-oxoethyl]hexanamide
CFAMM00258711 CHEMBL235109 Bioactive (2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-N-[(2S)-1-oxo-3-phenyl-1-[4-(N-propanoylanilino)piperidin-1-yl]propan-2-yl]-3-phenylpropanamide
CFAMM00258724 CHEMBL1649942 Bioactive (2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[2-[[(2S)-3-(4-fluorophenyl)-1-oxo-1-[4-(N-propanoylanilino)piperidin-1-yl]propan-2-yl]amino]-2-oxoethyl]hexanamide
CFAMM00258723 CHEMBL1649943 Bioactive (2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-3-(4-chlorophenyl)-1-oxo-1-[4-(N-propanoylanilino)piperidin-1-yl]propan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
CFAMM00258702 CHEMBL2028971 Bioactive (3S)-N-[(2S)-6-acetamido-1-anilino-1-oxohexan-2-yl]-2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00258708 DNC013690 Investigative Drug H-Dmt-Tic-Gly-N(Me)-Ph
CFAMM00258715 DNC013686 Investigative Drug H-Dmt-Tic-D-Asp-N(Me)-Ph
CFAMM00258714 DNC013689 Investigative Drug H-Dmt-Tic-Asp-NH-Ph
CFAMM00258713 DNC013688 Investigative Drug H-Dmt-Tic-D-Asp-NH-Ph
CFAMM00258726 DNC006752 Investigative Drug H-Dmt-Tic-Gly-NH-Ph
CFAMM00258718 DNC013115 Investigative Drug H-Dmt-Tic-Lys(Ac)-NH-Ph
CFAMM00258717 DNC013114 Investigative Drug H-Dmt-Tic-Lys-NH-Ph
CFAMM00258716 DNC013687 Investigative Drug H-Dmt-Tic-Asp-N(Me)-Ph

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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