CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2069
Family Name Delta-type opioid receptor and Mu-type opioid receptor Ligand 1,4-bis-(dmt-tic-amino)butane Family
No. of Seeds 31 No. of Other Members 5
Family Centroid CFAMM00258741 Functional Category Investigative Drug
Superfamily Mu-type opioid receptor and Delta-type opioid receptor Binder Superfamily
Class Class 1664

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Alpha-1 adrenergic receptor ligand arylethanolamine derivative... 4 37
Trypsin inhibitor polypeptide Aprotinin Family 7 68
Opioid receptor ligand opiate Levorphanol Family 18 537
Oxytocin receptor Ligand Oxytocin Family 30 182
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Thymopentin family 20 133
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Tryptase Inhibitor APC-366 Family 2 12
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU84687 F... 2 14
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Somatostatin receptor type 1 Ligand Des-aa1,2,5-[(nalphame)lys... 16 11
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-ethyl Estrone-16... 3 5
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 9 43
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 8
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 3 0
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 5 0
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 2 1
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
KiSS-1 receptor ligand (2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-... 1 0
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
C-X-C chemokine receptor type 4 ligand CHEMBL2372990 family 3 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(3-hydroxyp... 4 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 2 6
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 2 1
Pol polyprotein inhibitor 168912-67-2 family 1 0
Prothrombin inhibitor (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]... 2 1
Pol polyprotein inhibitor (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopy... 3 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Gonadotropin-releasing hormone receptor ligand (3R,6S,12S,15S,... 1 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(3-hydr... 1 0
Neuropeptide Y receptor type 1 ligand (2R)-5-[[amino-[[2-[2-[2... 1 0
N-acetylated-alpha-linked acidic dipeptidase 2 inhibitor (2S)-... 1 5
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 6
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-076B5T fa... 1 0
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Sigma non-opioid intracellular receptor 1 ligand N-(1-benzylpi... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00258748 CHEMBL119590 Bioactive (2S)-2-[[(2S)-2-[[2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-3,4-dihydro-1H-isoquinolin-3-yl]methylamino]-3-phenylpropanoyl]amino]-3-phenylpropanamide
CFAMM00258768 CHEMBL2370502 Bioactive (3S)-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-3-(4-hydroxy-2,6-dimethylphenyl)-2-(methylamino)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00258767 CHEMBL1076724 Bioactive (3S)-2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-N-[(E)-6-[[(3S)-2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]hex-3-enyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00258764 DNC013145 Investigative Drug H-Dmt-Tic-(2R,3R)-beta-MeCha-Phe-NH2
CFAMM00258741 DNC012900 Investigative Drug 1,4-bis-(Dmt-Tic-amino)butane
CFAMM00258761 DNC013146 Investigative Drug H-Dmt-Tic-(2S,3S)-beta-MeCha-Phe-NH2
CFAMM00258740 DNC012903 Investigative Drug 1,6-bis-(N,N-dimethyl-Dmt-Tic-NH)hexane
CFAMM00258753 DNC012897 Investigative Drug 3,6-bis(Dmt-Tic-NH-ethyl)-2(1H)-pyrazinone
CFAMM00258760 DNC013144 Investigative Drug H-Dmt-Tic-(2S,3R)-beta-MeCha-Phe-NH2
CFAMM00258739 DNC012902 Investigative Drug 1,10-bis-(Dmt-Tic-amino)decane
CFAMM00258752 DNC012899 Investigative Drug 3,6-bis(Dmt-Tic-NH-butyl)-2(1H)-pyrazinone
CFAMM00258745 DNC013117 Investigative Drug H-Dmt-Tic-Lys-NH-CH2-Ph
CFAMM00258759 DNC013143 Investigative Drug H-Dmt-Tic-(2R,3S)-beta-MeCha-Phe-NH2
CFAMM00258751 DNC012896 Investigative Drug 3,6-bis(Dmt-Tic-NH-methyl)-2(1H)-pyrazinone
CFAMM00258744 DNC013118 Investigative Drug H-Dmt-Tic-Lys(Ac)-NH-CH2-Ph
CFAMM00258750 DNC013380 Investigative Drug H-Tyr-Pro-Phe-Phe-NH-CH2-CH2-NH Tic Dmt-H
CFAMM00258766 DNC006753 Investigative Drug H-Dmt-Tic-Gly-NH-Bzl
CFAMM00258743 DNC012905 Investigative Drug H-Dmt-Tic-NH-(CH2)6-NH-Dmt-H
CFAMM00258757 DNC012912 Investigative Drug H-Dmt-Tic-NH-(CH2)6-NH-Tic-H
CFAMM00258749 DNC012898 Investigative Drug 3,6-bis(Dmt-Tic-NH-propyl)-2(1H)-pyrazinone
CFAMM00258742 DNC012901 Investigative Drug 1,6-bis-(Dmt-Tic-amino)hexane
CFAMM00258755 DNC012911 Investigative Drug H-Dmt-Tic-NH-(CH2)6-NH-Phe-H

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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