CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2071
Family Name Tubulin beta chain Inhibitor Combretastatin Family
No. of Seeds 3 No. of Other Members 5
Family Centroid CFAMM00258803 Functional Category Investigative Drug with Human Metabolite
Superfamily Tubulin beta chain and Arachidonate 5-lipoxygenase Binder Superfamily
Class Class 1561

Cousin Family NamesSeedsMembers
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor ligand Dienestrol Family 35 440
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Hidrosmin family 14 61
Rotenone family 16 107
Agrimophol family 10 22
Salicin family 5 629
Sodium/glucose cotransporter 2 Inhibitor Empagliflozin Family 32 52
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Glucokinase Inhibitor R7201 Family 22 105
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
TS-071 family 8 36
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Endothelin-1 receptor Ligand PD156707 Family 41 211
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Sodium/glucose cotransporter 2 Inhibitor Maackiain Family 1 5
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Protein kinase C alpha type Inhibitor Acetoside Family 5 39
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 2 1
Androgen receptor Ligand 2'-hydroxy-3-methoxy-biphenyl-4-carbo... 2 13
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
Cytochrome P450 3A4 Inhibitor Hinokinin Family 2 10
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Beta-secretase 1 Inhibitor Eckol Family 6 40
Heat shock cognate 71 kDa protein Inhibitor NSC-119913 Family 2 1
Tyrosinase Inhibitor 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-d... 4 2
Tyrosinase Inhibitor Kazinol S Family 1 0
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 7
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Estrogen receptor beta and Estrogen receptor ligand 3-fluoro-4... 6 42
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
Vitamin D3 receptor ligand (1R,3S,5Z)-5-[(2E)-2-[(3aS,7aR)-1-[... 1 2
Low affinity sodium-glucose cotransporter and Sodium/glucose c... 1 0
Platelet-activating factor receptor ligand (2S,3R,3aS)-2-(3,4-... 2 7
Estradiol 17-beta-dehydrogenase 1 inhibitor SureCN4589665 family 2 4
Cytochrome P450 1A1 and Cytochrome P450 1B1 inhibitor 1,2,4-tr... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor 5,10-... 1 0
Androgen receptor ligand AGN-PC-00BPQ5 family 1 3
Receptor-type tyrosine-protein phosphatase C and Tyrosine-prot... 1 0
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial ... 1 1
Epidermal growth factor receptor ligand NSC650565 family 1 0
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Phenols and Derivatives Metabolite 3,4-Dihydroxyphenylglycol O... 1 1
Lignans and Norlignans Metabolite cis-Miyabenol C Family 3 0
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
Phenols and Derivatives Metabolite 6-Gingesulfonic acid Family 1 2
NP (1r,2r,4s)-2-(2-methoxyphenyl)-1,3,3-trimethylbicyclo[2.2.1... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00258803 DNC006758 Investigative Drug COMBRETASTATIN
CFAMM00258795 DNC014142 Investigative Drug Nectamazin C
CFAMM00258791 DNC014627 Investigative Drug 2-Methoxy-5-(5,6,7-trimethoxy-indan-1-yl)-phenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26855 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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