CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2072
Family Name Suppressor of tumorigenicity 14 protein Inhibitor 3-tapap Family
No. of Seeds 15 No. of Other Members 39
Family Centroid CFAMM00258835 Functional Category Investigative Drug
Superfamily Suppressor of tumorigenicity 14 protein and Trypsin Binder Superfamily
Class Class 1568

Cousin Family NamesSeedsMembers
Prothrombin Inhibitor Ximelagatran Family 5 48
Cathepsin K Inhibitor Odanacatib Family 33 84
Upamostat family 1 13
Suppressor of tumorigenicity 14 protein and Prothrombin Inhibi... 4 126
Prothrombin Inhibitor LB30812 Family 12 36
Prothrombin Inhibitor D-leucyl-n-(4-carbamimidoylbenzyl)-l-pro... 13 44
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-valp... 8 5
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Trypsin Inhibitor Benzamidrazone Analogue Family 16 6
Coagulation factor X inhibitor (6S,8aS)-2-benzhydrylsulfonyl-N... 5 5
Plasminogen and Plasma kallikrein inhibitor CHEMBL2016864 family 9 16
Prothrombin inhibitor (2S)-N-[(4-carbamimidoylthiophen-2-yl)me... 12 9
Prothrombin and Suppressor of tumorigenicity 14 protein inhibi... 5 8
Prothrombin and Cationic trypsin inhibitor 2-[butyl-[(2S)-4-[[... 7 32
Prothrombin inhibitor SureCN7341151 family 6 7
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-044L... 6 7
Prothrombin inhibitor (2S)-N-[4-(2-amino-2-iminoethyl)cyclohex... 2 0
Trypsin-1 and Urokinase-type plasminogen activator inhibitor (... 3 9
Coagulation factor X and Trypsin-1 inhibitor SureCN6161266 family 2 28
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
B1 bradykinin receptor ligand SureCN13936521 family 19 4
Prothrombin and Coagulation factor X inhibitor tert-butyl (4R)... 1 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 9 0
B1 bradykinin receptor ligand N-[(1R)-6-[(dimethylamino)methyl... 7 6
Prothrombin inhibitor 2-[3-(benzylsulfonylamino)-6-methyl-2-ox... 2 3
Cathepsin K and Cathepsin L1 inhibitor N-[1-(cyanomethylcarbam... 2 0
B1 bradykinin receptor ligand 2-[2-(3,4-dichlorophenyl)sulfony... 3 0
B1 bradykinin receptor ligand N-[2-[4-(4,5-dihydro-1H-imidazol... 2 0
Suppressor of tumorigenicity 14 protein and Plasminogen inhibi... 10 15
B1 bradykinin receptor and B2 bradykinin receptor ligand SureC... 3 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Prothrombin and Cationic trypsin inhibitor (2S)-3-(5-carbamimi... 2 0
Coagulation factor X inhibitor ethyl 2-[[(3S)-3-[[2-[[(2R)-2-(... 4 0
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7307400... 1 3
Trypsin-1 inhibitor (2R)-1-[(2S)-3-(4-carbamimidoylphenyl)-2-[... 1 0
Motilin receptor ligand N-[[2-[4-[[(3S,5R)-3,5-dimethylpiperaz... 2 0
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Suppressor of tumorigenicity 14 protein and Prothrombin inhibi... 2 5
Prothrombin and Cationic trypsin inhibitor (2R)-N-[[(3S)-1-car... 1 2
Prothrombin inhibitor (2S)-3-[4-[amino(hydrazinyl)methyl]pheny... 1 0
Suppressor of tumorigenicity 14 protein and Prothrombin inhibi... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00258818 CHEMBL7656 Bioactive (2S)-3-(4-carbamimidoylphenyl)-N-cyclopentyl-N-methyl-2-(naphthalen-2-ylsulfonylamino)propanamide
CFAMM00258823 CHEMBL46842 Bioactive (2S)-3-(4-carbamimidoylphenyl)-N-cyclopentyl-N-methyl-2-[(4-propylphenyl)sulfonylamino]propanamide
CFAMM00258816 CHEMBL162216 Bioactive 4-[3-[(3S)-3-(benzenesulfonamido)-2-oxoazepan-1-yl]-2-oxopropyl]benzenecarboximidamide
CFAMM00258819 CHEMBL104731 Bioactive 3-[(2R)-3-(4-methylpiperidin-1-yl)-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamide
CFAMM00258835 DNC006761 Investigative Drug 3-tapap

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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