CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2076
Family Name E3 ubiquitin-protein ligase Mdm2 Inhibitor NSC-66811 Family
No. of Seeds 4 No. of Other Members 27
Family Centroid CFAMM00258944 Functional Category Investigative Drug
Superfamily Metabotropic glutamate receptor 5 and E3 ubiquitin-protein ligase Mdm2 Binder Superfamily
Class Class 1788

Cousin Family NamesSeedsMembers
Histamine N-methyltransferase inhibitor aminoquinoline Amodiaq... 8 23
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 4
Arachidonate 12-lipoxygenase, 12S-type Inhibitor NSC-125034 Fa... 1 0
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-0886S... 1 18
Glucocorticoid receptor ligand 4-fluoro-2-[5,5,5-trifluoro-4-h... 3 9
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Androgen receptor ligand (6R,7S)-6-ethyl-7-methyl-4-(trifluoro... 22 29
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
D(4) dopamine receptor ligand AGN-PC-00SXAZ family 2 4
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C9 liga... 2 6
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
ATP-dependent molecular chaperone HSP82 and Arachidonate 12-li... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00258985 CHEMBL1172618 Bioactive AGN-PC-0886LY
CFAMM00258960 CHEMBL1173521 Bioactive AGN-PC-0886MU
CFAMM00258957 CHEMBL1173662 Bioactive AGN-PC-0886Q0
CFAMM00258944 DNC006772 Investigative Drug NSC-66811

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27620 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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