CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2077
Family Name Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic Acid Family
No. of Seeds 2 No. of Other Members 44
Family Centroid CFAMM00259042 Functional Category Investigative Drug
Superfamily Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic Acid Superfamily
Class Class 530

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
Cyclooxygenase Inhibitor Ketorolac Family 3 40
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Neuromedin-K receptor Ligand Talnetant Family 3 49
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Retinoic acid receptor alpha Ligand LG100268 Family 2 33
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Dihydroorotate dehydrogenase Inhibitor Cinchoninic Acid Family 1 21
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
AP endonuclease APE1 Inhibitor 5-fluoro-1h-indole-2-carboxylic... 2 61
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Fatty acid-binding protein, adipocyte Inhibitor 2-(3-methyl-in... 5 9
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 3 11
Tyrosine-protein phosphatase non-receptor type 1 Ligand Cauler... 2 8
Fatty acid-binding protein, adipocyte Inhibitor 1-benzyl-2,3-d... 1 8
Kinesin-like protein KIF11 Inhibitor Methyl 7-tert-butyl-9h-ca... 2 9
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Metabotropic glutamate receptor 5 Ligand (3-(2-methylquinolin-... 3 6
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 8 17
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Leukotriene B4 receptor 1 ligand SureCN8772238 family 1 1
NS5B protein inhibitor AC1NQMYG family 6 12
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4R,... 3 7
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 2
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QM95 family 1 1
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor AG... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
NS5B protein inhibitor AGN-PC-00A17Z family 1 23
NS5B protein inhibitor AC1O5AET family 3 1
NS5B protein inhibitor AC1NQMYP family 5 0
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 ligand 4-[2-[4-[[(1-propan-2-yl... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 3
Phospholipase A2, membrane associated inhibitor AGN-PC-075RBK ... 1 2
Gonadotropin-releasing hormone receptor ligand 4-[2-[[(2S)-2-[... 1 0
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Glutamate carboxypeptidase 2 inhibitor 1-[(3-carboxyphenyl)met... 4 11
Glutamate receptor 4 and Glutamate receptor 2 ligand SureCN437... 4 12
Thrombopoietin receptor ligand AGN-PC-077M9L family 2 4
Prostaglandin E synthase inhibitor 3-(4-dodecanoyl-1,5-dimethy... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00258998 CHEMBL425693 Bioactive AC1LAI8C
CFAMM00259042 DNC006773 Investigative Drug 3-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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