CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2083
Family Name Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family
No. of Seeds 39 No. of Other Members 43
Family Centroid CFAMM00259201 Functional Category Investigative Drug
Superfamily Adenosine receptor A2a and Serine/threonine-protein kinase mTOR Binder Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-3328 family 2 32
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Adenosine receptor A1 and Adenosine receptor A2a Ligand CGS-15... 24 47
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Adenosine receptor A2a ligand SureCN6867940 family 13 13
Receptor-type tyrosine-protein kinase FLT3 and Hepatocyte grow... 7 56
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 10 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 8 0
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Adenosine receptor A3 and Adenosine receptor A2b ligand CHEMBL... 5 0
Survival motor neuron protein and Neuropeptide S receptor liga... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 7 4
Adenosine receptor A2a ligand 5-[[[(2R)-1-[(2-chloropyridin-4-... 5 0
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Adenosine receptor A2a ligand 7-(3,4-dimethoxyphenyl)-2-(furan... 6 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Adenosine receptor A3 ligand CHEMBL1834703 family 2 1
Vascular endothelial growth factor receptor 1 and Vascular end... 11 38
Histamine H4 receptor ligand 8-fluoro-4-[(3R)-3-(methylamino)p... 6 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1938684 ... 5 6
Prothrombin and Coagulation factor X inhibitor SureCN6929748 f... 6 5
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 1 0
Hepatocyte growth factor receptor ligand 2-[2-amino-5-(1-piper... 4 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 6
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S... 6 1
Mitogen-activated protein kinase kinase kinase 7 and TGF-beta-... 3 14
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 3
Adenosine receptor A2a ligand 3-[(2-bromophenyl)methyl]-8-(fur... 2 0
Adenosine receptor A2a ligand 8-(furan-2-yl)-3-[2-[4-(1,3-thia... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 25 5
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Adenosine receptor A3 and Adenosine receptor A2a ligand (3R,4S... 1 0
Adenosine receptor A2a ligand SureCN8368237 family 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Vascular endothelial growth factor receptor 2 and Vascular end... 2 8
Vascular endothelial growth factor receptor 2 and Vascular end... 2 1
Inosine-5'-monophosphate dehydrogenase 2 inhibitor AC1LAY14 fa... 2 1
Metabotropic glutamate receptor 5 ligand AGN-PC-09QKEE family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00259206 CHEMBL212898 Bioactive SureCN4762691
CFAMM00259219 CHEMBL210060 Bioactive SureCN4769307
CFAMM00259233 CHEMBL209644 Bioactive AGN-PC-046R3U
CFAMM00259279 CHEMBL379374 Bioactive AGN-PC-046R3Y
CFAMM00259212 CHEMBL211362 Bioactive AGN-PC-046R3C
CFAMM00259226 CHEMBL378919 Bioactive AGN-PC-046R3T
CFAMM00259265 CHEMBL439321 Bioactive 4-(2,5-difluorophenyl)-5-[3-(1-methylcyclobutyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]-1,3-oxazole
CFAMM00259232 CHEMBL213374 Bioactive SureCN4762399
CFAMM00259218 CHEMBL379929 Bioactive SureCN5774497
CFAMM00259197 CHEMBL212294 Bioactive 4-(2-chlorophenyl)-5-(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1,3-oxazole
CFAMM00259211 CHEMBL213451 Bioactive AGN-PC-046R3K
CFAMM00259238 CHEMBL212849 Bioactive AGN-PC-046R3N
CFAMM00259251 CHEMBL377757 Bioactive AGN-PC-03MOWI
CFAMM00259264 CHEMBL380030 Bioactive SureCN4764009
CFAMM00259210 CHEMBL377319 Bioactive SureCN4762684
CFAMM00259196 CHEMBL211628 Bioactive SureCN4762560
CFAMM00259237 CHEMBL379866 Bioactive SureCN4762527
CFAMM00259250 CHEMBL212708 Bioactive SureCN4767753
CFAMM00259203 CHEMBL439540 Bioactive AGN-PC-046R3G
CFAMM00259263 CHEMBL211735 Bioactive AGN-PC-046R3H
CFAMM00259269 CHEMBL215652 Bioactive 4-(2-chloro-4-fluorophenyl)-5-(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1,3-oxazole
CFAMM00259222 CHEMBL214310 Bioactive SureCN4762629
CFAMM00259236 CHEMBL215899 Bioactive SureCN4762486
CFAMM00259275 CHEMBL212968 Bioactive SureCN4219451
CFAMM00259215 CHEMBL379394 Bioactive AGN-PC-046R3V
CFAMM00259268 CHEMBL213159 Bioactive 5-[3-(1-methylcyclobutyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]-4-(2,4,5-trifluorophenyl)-1,3-oxazole
CFAMM00259208 CHEMBL212341 Bioactive SureCN4762539
CFAMM00259221 CHEMBL213598 Bioactive AGN-PC-046R3F
CFAMM00259235 CHEMBL377841 Bioactive AGN-PC-046R3I
CFAMM00259248 CHEMBL212382 Bioactive SureCN4765319
CFAMM00259274 CHEMBL213258 Bioactive AGN-PC-02WJRC
CFAMM00259228 CHEMBL211919 Bioactive AGN-PC-046R3P
CFAMM00259241 CHEMBL384795 Bioactive AGN-PC-046R3Z
CFAMM00259247 CHEMBL212655 Bioactive AGN-PC-046R3M
CFAMM00259260 CHEMBL212238 Bioactive 4-(5-chloro-2-fluorophenyl)-5-(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1,3-oxazole
CFAMM00259199 CHEMBL213423 Bioactive SureCN4762364
CFAMM00259273 CHEMBL215858 Bioactive SureCN5771520
CFAMM00259266 CHEMBL379590 Bioactive 4-(4-chloro-2-fluorophenyl)-5-(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1,3-oxazole
CFAMM00259201 DNC006794 Investigative Drug CP-808844

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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