CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID209
Family Name C-C chemokine receptor type 1 Ligand BX-471 Family
No. of Seeds 10 No. of Other Members 67
Family Centroid CFAMM00184318 Functional Category Investigative Drug
Superfamily C-C chemokine receptor type 1 Ligand BX-471 Superfamily
Class Class 217

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Loxapine Family 5 6
Calcium-activated potassium channel subunit alpha-1 Ligand Chl... 2 15
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Tubulin Inhibitor WR85915 Family 3 15
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
D(4) dopamine receptor ligand AGN-PC-004XJQ family 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 0
Survival motor neuron protein and Lysine-specific demethylase ... 1 1
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 11 12
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Neuropeptide Y receptor type 5 ligand 2-(7-chloro-3-oxo-1,4-be... 3 3
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 2 3
C-C chemokine receptor type 1 ligand SureCN3164653 family 2 1
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 1
Translocator protein inhibitor AGN-PC-00CH84 family 3 0
D(2) dopamine receptor and Muscarinic acetylcholine receptor M... 1 0
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
C-C chemokine receptor type 1 ligand N-[2-[(2S)-3-(5-chlorospi... 5 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 10 1
C-C chemokine receptor type 1 ligand N-[2-[(2S)-3-(5-chlorospi... 4 0
C-C chemokine receptor type 1 ligand N-[2-[(2S)-2-amino-3-(5-f... 3 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor 3-chloro-N-cyclopropy... 1 2
Poly [ADP-ribose] polymerase 1 inhibitor 6-[[4-(4-chlorophenyl... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Progesterone receptor ligand CHEMBL252850 family 2 0
Progesterone receptor ligand CHEMBL253735 family 2 0
Urotensin-2 receptor and Kappa-type opioid receptor ligand 6,7... 2 0
Alpha-1D adrenergic receptor and D(2) dopamine receptor ligand... 3 0
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 5-chloro-3... 2 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
Melanin-concentrating hormone receptor 1 and D(2) dopamine rec... 1 0
Transient receptor potential cation channel subfamily V member... 1 2
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJY family 5 4
Growth hormone secretagogue receptor type 1 ligand N-benzyl-2-... 5 19
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Acyl-CoA desaturase and Acyl-CoA desaturase 1 inhibitor SureCN... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 0
Muscarinic acetylcholine receptor M1 and Microtubule-associate... 1 0
P2X purinoceptor 7 inhibitor SureCN3722920 family 4 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 1
D(2) dopamine receptor and D(3) dopamine receptor ligand 1-(3-... 2 0
Histone deacetylase 8 inhibitor benzyl N-[(2S)-1-(3-chloroanil... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-[2-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00184310 CHEMBL403138 Bioactive CHEMBL403138
CFAMM00184309 CHEMBL271913 Bioactive AGN-PC-00RZMK
CFAMM00184383 CHEMBL232441 Bioactive 3-amino-4-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]anilino]cyclobut-3-ene-1,2-dione
CFAMM00184359 CHEMBL232837 Bioactive 3-(2-aminoethylamino)-4-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]anilino]cyclobut-3-ene-1,2-dione
CFAMM00184328 CHEMBL257077 Bioactive AGN-PC-00RZHM
CFAMM00184354 CHEMBL387608 Bioactive 3-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]anilino]-4-(2-piperazin-1-ylethylamino)cyclobut-3-ene-1,2-dione
CFAMM00184311 CHEMBL391238 Bioactive SureCN6832213
CFAMM00184318 DNC005897 Investigative Drug BX-471
CFAMM00184285 DNC000368 Investigative Drug BX 471

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27278 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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