CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2090
Family Name Sodium-dependent noradrenaline transporter and Sodium-dependent serotonin transporter Inhibitor 1-(2-(2-bromophenyl)-1-phenylethyl)piperazine Family
No. of Seeds 3 No. of Other Members 10
Family Centroid CFAMM00259576 Functional Category Investigative Drug
Superfamily Sodium-dependent noradrenaline transporter and Sodium-dependent serotonin transporter Inhibitor 1-(2-(2-bromophenyl)-1-phenylethyl)piperazine Superfamily
Class Class 2346

Cousin Family NamesSeedsMembers
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Beta adrenergic receptor Ligand Bretylium Family 3 11
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Substance-P receptor Ligand Vestipitant Family 14 137
Zicronapine family 43 62
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 12 0
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0
D(1A) dopamine receptor and 5-hydroxytryptamine receptor 2A li... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 3
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-003L8Y... 2 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-yle... 8 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 2 8
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 6
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
D(2) dopamine receptor ligand AGN-PC-041NNJ family 1 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
C-X-C chemokine receptor type 3 ligand [4-(2-bromophenyl)pheny... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00259578 CHEMBL270474 Bioactive 1-[(2-bromophenyl)methyl]-4-(3-phenylpropyl)piperazine
CFAMM00259576 DNC006819 Investigative Drug 1-(2-(2-bromophenyl)-1-phenylethyl)piperazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543