CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2091
Family Name Sodium-dependent dopamine transporter and Sodium-dependent noradrenaline transporter Inhibitor 3-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol Family
No. of Seeds 9 No. of Other Members 16
Family Centroid CFAMM00259590 Functional Category Investigative Drug
Superfamily Sodium-dependent dopamine transporter and Sodium-dependent noradrenaline transporter Inhibitor 3-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol Superfamily
Class Class 1712

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Opioid receptor ligand opiate Levorphanol Family 18 537
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor Ligand Alvimopan Family 32 325
D(2) dopamine receptor Ligand Quinagolide Family 2 0
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Eptazocine Hbr family 6 8
Thymopentin family 20 133
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Substance-P receptor Ligand Ezlopitant Family 10 207
CORT-108297 family 46 44
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Amine oxidase [flavin-containing] B Inhibitor 5-hydroxy-n-prop... 3 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 0
Acetylcholinesterase and Cholinesterase Inhibitor N,n'-(1',10'... 12 8
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-ethyl Estrone-16... 3 5
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Tubulin beta chain Inhibitor Colchinol Family 3 109
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
5-hydroxytryptamine receptor 1A ligand SureCN7035190 family 10 17
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TF5... 1 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TFC... 2 7
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 7 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-01Z... 2 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Sigma non-opioid intracellular receptor 1 ligand CHEMBL154452 ... 2 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Potassium voltage-gated channel subfamily H member 2 ligand 4-... 1 3
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 0
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 3 8
Transporter and Sodium-dependent serotonin transporter inhibit... 1 5
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
D(1A) dopamine receptor and D(2) dopamine receptor ligand (2R,... 1 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(3-hydr... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 5
DNA polymerase beta and Thioredoxin glutathione reductase inhi... 1 5
Alpha-2A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00259601 CHEMBL2112473 Bioactive SureCN4697124
CFAMM00259599 DNC010900 Investigative Drug (R)-2-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol
CFAMM00259590 DNC006825 Investigative Drug 3-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol
CFAMM00259604 DNC011759 Investigative Drug SL-3111

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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