CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2100
Family Name Delta-type opioid receptor and Kappa-type opioid receptor Ligand 8-carboxamidocyclazocine Family
No. of Seeds 41 No. of Other Members 24
Family Centroid CFAMM00259748 Functional Category Investigative Drug
Superfamily Delta-type opioid receptor and Kappa-type opioid receptor Ligand 8-carboxamidocyclazocine Superfamily
Class Class 852

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Opioid receptor Ligand Methadone Family 3 39
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
DNA Binder Procarbazine Family 8 358
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Neuromedin-K receptor Ligand Osanetant Family 38 192
Motilin receptor Ligand GSK962040 Family 30 457
Substance-P receptor Ligand Orvepitant Family 11 46
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Aldose reductase Inhibitor Alrestatin Family 2 11
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Urokinase-type plasminogen activator Inhibitor 6-(n-phenylcarb... 2 11
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Poly [ADP-ribose] polymerase 1 Inhibitor 8-fluoro-6h,11h-inden... 2 2
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Sodium-dependent dopamine transporter and Sodium-dependent nor... 10 28
Caspase-3 Inhibitor 2-phenethylisoquinoline-1,3,4-trione Family 6 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Acetyl-CoA carboxylase 1 and Acetyl-CoA carboxylase 2 Inhibito... 1 0
Cathepsin G and Chymase Inhibitor JNJ-10311795 Family 1 3
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 4 10
Thyroid hormone receptor beta Ligand 1-(4-hexylphenyl)-3-(prop... 2 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Poly [ADP-ribose] polymerase 1 Inhibitor 5-aminoisoquinolin-1(... 2 8
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Histone deacetylase 1 Inhibitor N-hydroxy-7-(naphthalen-2-yl)-... 3 2
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmethylma... 2 2
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor Phenanthrene-3-carboxyli... 7 4
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(3-... 1 7
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
C-C chemokine receptor type 5 ligand AC1NUIO8 family 12 11
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [2... 2 4
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 8
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745OU family 6 6
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 3 13
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 18
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2,5-dichlor... 3 4
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 12 8
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Acetylcholinesterase inhibitor AC1MIM21 family 2 7
5-hydroxytryptamine receptor 1A ligand U93385 family 4 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-[4-... 30 10
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 4
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Metabotropic glutamate receptor 5 ligand SureCN504295 family 1 7
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Melanin-concentrating hormone receptor 1 ligand 1-(3-acetyl-1,... 8 4
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 7 3
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Dipeptidyl peptidase 4 inhibitor 4-cyano-N-[4-[(2S)-2-cyanopyr... 1 1
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Substance-P receptor ligand AGN-PC-073QYE family 6 11
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 4 4
C-C chemokine receptor type 2 ligand (1S,3R)-N-[[3-fluoro-5-(t... 22 27
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Cannabinoid receptor 2 ligand 1-adamantyl(1,3-dihydroisoindol-... 1 0
Nociceptin receptor and Kappa-type opioid receptor ligand Pipe... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 1
5-hydroxytryptamine receptor 1A ligand [(7S,8R)-7-(dipropylami... 4 0
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN6949669... 12 3
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Plasmepsin-2 inhibitor SureCN8292428 family 1 2
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-bromobenz... 1 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 4
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 5
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
Oxytocin receptor and Vasopressin V1a receptor ligand N-(cyclo... 4 5
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 22
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 1A ligand 8-[4-[[(2R)-8-acetyl-5-... 1 0
Legumain-like protease inhibitor N-[(2R)-1-[[(2S)-1-[2-(2-amin... 6 7
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TEL... 1 7
B1 bradykinin receptor ligand 4-(4-oxothiochromen-3-yl)-N-[(1R... 1 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 1
Substance-P receptor ligand AGN-PC-0760FI family 1 0
Lanosterol synthase and Squalene--hopene cyclase inhibitor AGN... 2 5
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 1 1
Coagulation factor X and Coagulation factor VII inhibitor AGN-... 1 2
Progesterone receptor ligand AGN-PC-048NI9 family 1 5
Histone deacetylase 6 inhibitor AGN-PC-0C5HOH family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00259725 CHEMBL522375 Bioactive CHEMBL522375
CFAMM00259766 CHEMBL349502 Bioactive (3aR,9bS)-3-(cyclopropylmethyl)-1,2,3a,4,5,9b-hexahydrobenzo[e]indole-9-carboxamide
CFAMM00259745 CHEMBL378355 Bioactive CHEMBL378355
CFAMM00259758 CHEMBL250387 Bioactive SureCN12306960
CFAMM00259751 CHEMBL511691 Bioactive CHEMBL511691
CFAMM00259730 CHEMBL493621 Bioactive CHEMBL493621
CFAMM00259744 CHEMBL210005 Bioactive CHEMBL210005
CFAMM00259757 CHEMBL300033 Bioactive CHEMBL300033
CFAMM00259736 CHEMBL377789 Bioactive SureCN12298934
CFAMM00259764 CHEMBL464230 Bioactive AGN-PC-04XEQ3
CFAMM00259743 CHEMBL401278 Bioactive SureCN12306969
CFAMM00259735 CHEMBL60869 Bioactive CHEMBL60869
CFAMM00259728 CHEMBL461229 Bioactive AGN-PC-074A8A
CFAMM00259721 CHEMBL433272 Bioactive CHEMBL433272
CFAMM00259727 CHEMBL2208355 Bioactive AGN-PC-00S51B
CFAMM00259733 CHEMBL27313 Bioactive 1-Naphthalenecarboxamide, 7-(dipropylamino)-5,6,7,8-tetrahydro-
CFAMM00259760 CHEMBL399344 Bioactive SureCN12306965
CFAMM00259726 CHEMBL2208357 Bioactive AGN-PC-00JKA5
CFAMM00259767 CHEMBL297428 Bioactive AGN-PC-0BVFK9
CFAMM00259732 CHEMBL296282 Bioactive CHEMBL296282
CFAMM00259759 CHEMBL2368218 Bioactive CHEMBL2368218
CFAMM00259748 DNC006841 Investigative Drug 8-carboxamidocyclazocine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27744 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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