CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2113
Family Name Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-(1-benzyl-piperidin-4-yl)-urea Family
No. of Seeds 11 No. of Other Members 6
Family Centroid CFAMM00260189 Functional Category Investigative Drug
Superfamily Substance-P receptor Ligand Vestipitant Superfamily
Class Class 1148

Cousin Family NamesSeedsMembers
Substance-P receptor Ligand Orvepitant Family 11 46
Substance-P receptor Ligand Vestipitant Family 14 137
Glycogen synthase kinase-3 Inhibitor NP12 Family 3 5
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 3 12
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 2
Cellular tumor antigen p53 and Retinal dehydrogenase 1 inhibit... 1 4
C-C chemokine receptor type 3 ligand 1-(2,3-dimethyl-3a,7a-dih... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 5
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 1
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 1
Neuropeptide Y receptor type 5 ligand 3-[4-(3,5-difluorophenyl... 1 0
C-C chemokine receptor type 5 ligand AC1L9YPM family 3 6
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 1
Prostaglandin E synthase inhibitor AGN-PC-09QMEJ family 2 0
Melanin-concentrating hormone receptor 1 ligand 1-[[4-(4-fluor... 2 10
Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 7


External ID

Functional Category

Molecule Name

CFAMM00260199 CHEMBL597234 Bioactive AGN-PC-07RABB
CFAMM00260188 CHEMBL605538 Bioactive AGN-PC-07RA9Y
CFAMM00260197 CHEMBL605544 Bioactive AGN-PC-07RABA
CFAMM00260185 CHEMBL604589 Bioactive AGN-PC-07RAB7
CFAMM00260192 CHEMBL1818394 Bioactive 1-(2-adamantyl)-3-(2-phenylethyl)urea
CFAMM00260194 CHEMBL2031923 Bioactive 1-(1-adamantyl)-3-(3-phenylpropyl)urea
CFAMM00260201 CHEMBL243522 Bioactive AGN-PC-015HGA
CFAMM00260182 CHEMBL598039 Bioactive AGN-PC-07RAB9
CFAMM00260193 CHEMBL603885 Bioactive AGN-PC-07RAB8
CFAMM00260200 DNC007096 Investigative Drug 1-adamantan-1-yl-3-((R)-1-phenyl-ethyl)-urea
CFAMM00260189 DNC006882 Investigative Drug 1-adamantan-1-yl-3-(1-benzyl-piperidin-4-yl)-urea

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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