CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2116
Family Name Androgen receptor Ligand 6-n-propyl -4-trifluoromethylquinolin-2(1h)-one Family
No. of Seeds 29 No. of Other Members 13
Family Centroid CFAMM00260279 Functional Category Investigative Drug
Superfamily Androgen receptor Ligand 6-n-propyl -4-trifluoromethylquinolin-2(1h)-one Superfamily
Class Class 1903

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Androgen receptor ligand aniline derivative Flutamide Family 3 9
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
3-hydroxy-3-methylglutaryl-coenzyme A reductase Inhibitor Simv... 4 27
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Androgen receptor Ligand LG-121071 Family 8 32
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Transient receptor potential cation channel subfamily V member... 6 33
Androgen receptor Ligand YM-175735 Family 30 129
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 9h-bet... 1 1
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 8 3
Tyrosinase Inhibitor S-2-(o-toluidino)-2-oxoethyl Carbamothioa... 1 1
Androgen receptor and Progesterone receptor ligand (5bR,9aR)-1... 1 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 3
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Androgen receptor ligand 6-[(2R,5R)-2-methyl-5-[(1S)-2,2,2-tri... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 6-ter... 2 7
Histamine receptor H3 ligand N-[2-methyl-4-[(3S)-3-[(2S)-2-met... 10 7
Histamine receptor H3 ligand N-[4-[3-(2-methylpyrrolidin-1-yl)... 2 0
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 3 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Metabotropic glutamate receptor 2 ligand 4-[4-(methylamino)phe... 1 4
3-prop-2-enyl-1H-quinolin-4-one NP 6-amino-2-methylquinolin-4-... 5 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00260261 CHEMBL393864 Bioactive 6-[butyl(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260241 CHEMBL391798 Bioactive 6-[bis(2,2,2-trifluoroethyl)amino]-1H-quinolin-2-one
CFAMM00260254 CHEMBL428026 Bioactive 6-[2,2-dichloroethyl(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260267 CHEMBL394194 Bioactive 6-[[(2R)-1-chloropropan-2-yl]-(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260283 CHEMBL440980 Bioactive 6-[2,2-difluoroethyl(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260247 CHEMBL238331 Bioactive 6-[bis(2,2,2-trifluoroethyl)amino]-4-chloro-1H-quinolin-2-one
CFAMM00260273 CHEMBL393664 Bioactive 6-[(2-chloro-2,2-difluoroethyl)-(2,2-difluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260253 CHEMBL235347 Bioactive 6-[[(2S)-1-chloropropan-2-yl]-(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260246 CHEMBL238330 Bioactive 6-[bis(2,2,2-trifluoroethyl)amino]-4-(difluoromethyl)-1H-quinolin-2-one
CFAMM00260259 CHEMBL244896 Bioactive SureCN1770551
CFAMM00260252 CHEMBL235346 Bioactive SureCN13210451
CFAMM00260245 CHEMBL238332 Bioactive 6-[bis(2,2,2-trifluoroethyl)amino]-4-bromo-1H-quinolin-2-one
CFAMM00260258 CHEMBL237045 Bioactive 6-[bis(2,2-difluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260271 CHEMBL442240 Bioactive SureCN1771005
CFAMM00260244 CHEMBL238122 Bioactive 6-[bis(2,2,2-trifluoroethyl)amino]-4-methyl-1H-quinolin-2-one
CFAMM00260257 CHEMBL237681 Bioactive 6-[2,2,3,3,3-pentafluoropropyl(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260270 CHEMBL237262 Bioactive 6-[propan-2-yl(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260250 CHEMBL237259 Bioactive 6-[methyl(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260263 CHEMBL393865 Bioactive 6-[butan-2-yl(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260277 CHEMBL237474 Bioactive 6-[2-chloroethyl(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260256 CHEMBL237682 Bioactive 6-[2-hydroxyethyl(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260243 CHEMBL238123 Bioactive 6-[bis(2,2,2-trifluoroethyl)amino]-4-ethyl-1H-quinolin-2-one
CFAMM00260269 CHEMBL237261 Bioactive 6-[propyl(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260275 CHEMBL237472 Bioactive 6-[2,2-dimethylpropyl(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260242 CHEMBL235127 Bioactive 6-[2,2,2-trifluoroethyl-[(2R)-1,1,1-trifluoropropan-2-yl]amino]-4-(trifluoromethyl)-1H-quinolin-2-one
CFAMM00260248 CHEMBL238124 Bioactive 6-[bis(2,2,2-trifluoroethyl)amino]-4-propan-2-yl-1H-quinolin-2-one
CFAMM00260281 DNC006892 Investigative Drug LGD-2226
CFAMM00260280 DNC006890 Investigative Drug 6-amino-4-trifluoromethylquinolin-2(1H)-one
CFAMM00260279 DNC006891 Investigative Drug 6-N-propyl -4-trifluoromethylquinolin-2(1H)-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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