CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2124
Family Name 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Ligand 1-[(3-methoxybenzyl)oxy]-2-(2-phenylethyl)benzene Family
No. of Seeds 2 No. of Other Members 214
Family Centroid CFAMM00260380 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Ligand 1-[(3-methoxybenzyl)oxy]-2-(2-phenylethyl)benzene Superfamily
Class Class 426

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor ligand Dienestrol Family 35 440
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Sodium channel Ligand Permethrin Family 1 25
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Salicin family 5 629
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
Dapoxetine family 3 40
TS-071 family 8 36
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Cathepsin S Inhibitor 2-[(2',3',4'-trifluorobiphenyl-2-yl)oxy]... 2 16
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Carbonic anhydrase 2 Inhibitor Sulfamic Acid Chroman-2-ylmethy... 1 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Leukotriene A-4 hydrolase Inhibitor 1-butoxy-4-phenoxybenzene ... 3 85
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Androgen receptor Ligand 3-methoxy-4-(m-tolyloxy)benzonitrile ... 3 29
Androgen receptor Ligand 4-(m-tolyloxy)-2-(trifluoromethyl)ben... 7 65
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Indoleamine 2,3-dioxygenase 1 Inhibitor Naphthalene-1,4-diol F... 2 4
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Amine oxidase [flavin-containing] B Inhibitor 7-fluoro-2-p-tol... 4 11
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
Peroxisome proliferator-activated receptor delta ligand SureCN... 1 0
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Vitamin D3 receptor ligand (1R,3S,5Z)-5-[(2E)-2-[(3aS,7aR)-1-[... 1 2
Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 1 1
Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... 1 0
Vitamin D3 receptor ligand 1-[4-[diethyl-[3-methyl-4-(oxiran-2... 1 1
Geranylgeranyl pyrophosphate synthase inhibitor [1-Hydroxy-2-(... 1 2
Beta-lactamase inhibitor AGN-PC-0A9UJZ family 1 3
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor 6-[te... 1 0
Cannabinoid receptor 1 and Monoglyceride lipase ligand 4-(4-ph... 4 4
D-amino-acid oxidase inhibitor 5-hydroxy-2-(naphthalen-1-yloxy... 2 0
Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-... 2 1
Geranylgeranyl pyrophosphate synthase inhibitor bisphosphonate... 1 1
Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7
Phenols and Derivatives Metabolite (±)-Flufenprox Family 1 13
Phenols and Derivatives Metabolite 2-(Ethoxymethyl)phenol Family 1 14
2-methyl-2H-chromene-3-carbaldehyde NP 2-methyl-2h-chromene-3-... 2 1
3-(2,3-dihydro-1,4-benzodioxin-6-yl)chromene-4-thione NP 3-(2,... 1 0
2-(4-methoxyphenyl)-10,10-dimethyl-1,3,9-trioxaspiro[5.5]undec... 4 19
4-(9H-xanthen-9-yl)-9H-xanthene NP 9h,9'h-4,9'-bixanthene Family 1 0
Putative NP ZINC00526277 Family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00260459 DNC011088 Investigative Drug 2-(benzyloxy)naphthalene
CFAMM00260380 DNC006914 Investigative Drug 1-[(3-methoxybenzyl)oxy]-2-(2-phenylethyl)benzene

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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